KEGG   ENZYME: 3.4.24.17Help
Entry
EC 3.4.24.17                Enzyme                                 
Name
stromelysin 1;
matrix metalloproteinase 3;
proteoglycanase;
collagenase activating protein;
procollagenase activator;
transin;
MMP-3;
neutral proteoglycanase;
stromelysin;
collagen-activating protein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage where P1', P2' and P3' are hydrophobic residues
Comment
An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family)
Orthology
K01394  
matrix metalloproteinase-3 (stromelysin 1, progelatinase)
Genes
HSA: 
4314(MMP3)
PTR: 
451511(MMP3)
PPS: 
100995831(MMP3)
GGO: 
101131989(MMP3)
PON: 
100461529(MMP3)
MCC: 
703762(MMP3)
MMU: 
17392(Mmp3)
RNO: 
171045(Mmp3)
CFA: 
403445(MMP3)
AML: 
FCA: 
101081492(MMP3)
BTA: 
281309(MMP3)
SSC: 
396769(MMP3)
ECB: 
100034195(MMP3)
MDO: 
100011059(MMP3)
SHR: 
100934169(MMP3)
OAA: 
100077197
GGA: 
418981(MMP10)
MGP: 
100544642
TGU: 
100221422 100227226
ACS: 
100552454 100561433
XLA: 
495372(mmp8)
XTR: 
100489571
 » show all
Taxonomy
Reference
1  [PMID:2995374]
  Authors
Chin JR, Murphy G, Werb Z.
  Title
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.
  Journal
J. Biol. Chem. 260 (1985) 12367-76.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:3095317]
  Authors
Okada Y, Nagase H, Harris ED Jr.
  Title
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.
  Journal
J. Biol. Chem. 261 (1986) 14245-55.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:2197998]
  Authors
Docherty AJ, Murphy G.
  Title
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
  Journal
Ann. Rheum. Dis. 49 (1990) 469-79.
Reference
4  [PMID:2165861]
  Authors
Emonard H, Grimaud JA.
  Title
Matrix metalloproteinases. A review.
  Journal
Cell. Mol. Biol. 36 (1990) 131-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
79955-99-0
DBGET integrated database retrieval system