KEGG   ENZYME: 3.4.24.21Help
Entry
EC 3.4.24.21                Enzyme                                 
Name
astacin;
Astacus proteinase;
crayfish small-molecule proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
Comment
A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.
Orthology
K08076  
astacin
Genes
CEL: 
CELE_4R79.1(nas-6) CELE_C07D10.4(nas-7) CELE_C24F3.3(nas-12) CELE_C26C6.3(nas-36) CELE_C34D4.9(nas-8) CELE_C37H5.9(nas-9) CELE_F09E8.6(nas-14) CELE_F38E9.2(nas-39) CELE_F40E10.1(hch-1) CELE_F42A10.8(nas-28) CELE_F45G2.1(nas-1) CELE_F46C5.3(nas-25) CELE_F57C12.1(nas-38) CELE_F58A6.4(nas-29) CELE_K03B8.1(nas-16) CELE_K03B8.2(nas-17) CELE_K03B8.3(nas-18) CELE_K04E7.3(nas-33) CELE_K06A4.1(nas-3) CELE_K09C8.3(nas-10) CELE_T02B11.7(nas-32) CELE_T04G9.2(nas-15) CELE_T11F9.3(nas-20) CELE_T23F4.4(nas-27) CELE_T23H4.3(nas-5) CELE_T24A11.3(toh-1)
CBR: 
CBG00430(Cbr-nas-6)
RDE: 
Taxonomy
Reference
1  [PMID:7041692]
  Authors
Krauhs E, Dorsam H, Little M, Zwilling R, Ponstingl H.
  Title
A protease from Astacus fluviatilis as an aid in protein sequencing.
  Journal
Anal. Biochem. 119 (1982) 153-7.
  Organism
Astacus fluviatilis
Reference
2  [PMID:3548817]
  Authors
Titani K, Torff HJ, Hormel S, Kumar S, Walsh KA, Rodl J, Neurath H, Zwilling R.
  Title
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis.
  Journal
Biochemistry. 26 (1987) 222-6.
  Organism
Astacus fluviatilis
Reference
3
  Authors
Stocker, W., Wolz, R.L., Zwilling, R., Strydom, D.J. and Auld, D.S.
  Title
Astacus protease, a zinc metalloenzyme.
  Journal
Biochemistry 27 (1988) 5026-5032.
Reference
4  [PMID:2261483]
  Authors
Stocker W, Ng M, Auld DS.
  Title
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease.
  Journal
Biochemistry. 29 (1990) 10418-25.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
143179-21-9
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