KEGG   ENZYME: 3.4.24.22Help
Entry
EC 3.4.24.22                Enzyme                                 
Name
stromelysin 2;
matrix metalloproteinase 10;
transin 2;
proteoglycanase 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar to stromelysin 1, but action on collagen types III, IV and V is weak
Comment
In peptidase family M10 (interstitial collagenase family). Digests gelatin types I, III, IV, V, fibronectin and proteoglycan
Orthology
K01396  
matrix metalloproteinase-10 (stromelysin 2)
Genes
HSA: 
4319(MMP10)
PTR: 
740658(MMP10)
PPS: 
100996180(MMP10)
GGO: 
101131626(MMP10)
PON: 
100460793(MMP10)
MCC: 
701793(MMP10)
MMU: 
17384(Mmp10)
RNO: 
117061(Mmp10)
FCA: 
101081247(MMP10)
XTR: 
594917(mmp3)
Taxonomy
Reference
1  [PMID:3547333]
  Authors
Breathnach R, Matrisian LM, Gesnel MC, Staub A, Leroy P.
  Title
Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene.
  Journal
Nucleic. Acids. Res. 15 (1987) 1139-51.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:2844164]
  Authors
Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R.
  Title
The collagenase gene family in humans consists of at least four members.
  Journal
Biochem. J. 253 (1988) 187-92.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:2548603]
  Authors
Nicholson R, Murphy G, Breathnach R.
  Title
Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases.
  Journal
Biochemistry. 28 (1989) 5195-203.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
140610-48-6
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