KEGG   ENZYME: 3.4.24.23Help
Entry
EC 3.4.24.23                Enzyme                                 
Name
matrilysin;
matrin;
uterine metalloendopeptidase;
matrix metalloproteinase 7;
putative (or punctuated) metalloproteinase-1;
matrix metalloproteinase pump 1;
MMP 7;
PUMP-1 proteinase;
PUMP;
metalloproteinase pump-1;
putative metalloproteinase;
MMP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Ala14!Leu and Tyr16!Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I)
Comment
Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll
Orthology
K01397  
matrix metalloproteinase-7 (matrilysin, uterine)
Genes
HSA: 
4316(MMP7)
PTR: 
451509(MMP7)
PPS: 
100969359(MMP7)
GGO: 
101129238(MMP7)
PON: 
100458458(MMP7)
MCC: 
703072(MMP7)
MMU: 
17393(Mmp7)
RNO: 
25335(Mmp7)
CFA: 
489432(MMP7)
AML: 
FCA: 
727698(MMP7)
BTA: 
286794(MMP7)
SSC: 
397411(MMP7)
ECB: 
100068985
MDO: 
100012296
SHR: 
100933647(MMP7)
OAA: 
100079035
GGA: 
418983(MMP7)
TGU: 
100231056
 » show all
Taxonomy
Reference
1  [PMID:2844164]
  Authors
Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R.
  Title
The collagenase gene family in humans consists of at least four members.
  Journal
Biochem. J. 253 (1988) 187-92.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:3182822]
  Authors
Woessner JF Jr, Taplin CJ.
  Title
Purification and properties of a small latent matrix metalloproteinase of the rat uterus.
  Journal
J. Biol. Chem. 263 (1988) 16918-25.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:2550050]
  Authors
Quantin B, Murphy G, Breathnach R.
  Title
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members.
  Journal
Biochemistry. 28 (1989) 5327-34.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:2253219]
  Authors
Miyazaki K, Hattori Y, Umenishi F, Yasumitsu H, Umeda M.
  Title
Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.
  Journal
Cancer. Res. 50 (1990) 7758-64.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
141256-52-2
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