KEGG   ENZYME: 3.4.24.24Help
Entry
EC 3.4.24.24                Enzyme                                 

Name
gelatinase A;
72-kDa gelatinase;
matrix metalloproteinase 2;
type IV collagenase;
3/4 collagenase (Obsolete);
matrix metalloproteinase 5 (Obsolete);
72 kDa gelatinase type A;
collagenase IV;
collagenase type IV;
MMP 2;
type IV collagen metalloproteinase;
type IV collagenase/gelatinase;
matrix metalloproteinase 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly!Ile-Ala-Gly-Gln
Comment
A secreted endopeptidase in peptidase family M10 (interstitial collagenase family), but possessing an additional fibronectin-like domain
History
EC 3.4.24.24 created 1992
Orthology
K01398  
matrix metalloproteinase-2 (gelatinase A)
K07761  
gelatinase A
Genes
HSA: 
4313(MMP2)
PTR: 
454094(MMP2)
PPS: 
100970966(MMP2)
GGO: 
101147102(MMP2)
PON: 
100451667(MMP2)
MCC: 
698478(MMP2)
MCF: 
MMU: 
17390(Mmp2)
RNO: 
81686(Mmp2)
CGE: 
100774744(Mmp2)
HGL: 
101696977(Mmp2)
TUP: 
102483061(MMP2)
CFA: 
403733(MMP2)
AML: 
100476183(MMP2)
FCA: 
101098838(MMP2)
PTG: 
102956398(MMP2)
BTA: 
282872(MMP2)
BOM: 
102269336(MMP2)
PHD: 
102315493(MMP2)
CHX: 
102184364(MMP2)
SSC: 
397391(MMP2)
CFR: 
BACU: 
103016736(MMP2)
LVE: 
103071760(MMP2)
ECB: 
100033948(MMP2)
MYB: 
102260608(MMP2)
MYD: 
102767174(MMP2)
PALE: 
102883808(MMP2)
MDO: 
100020585(MMP2)
SHR: 
100935012(MMP2)
OAA: 
100077120(MMP2)
GGA: 
386583(MMP2)
MGP: 
100125331(MMP2)
TGU: 
100228546(MMP2)
FAB: 
101815345(MMP2)
PHI: 
102107059(MMP2)
APLA: 
FPG: 
101924896(MMP2)
FCH: 
102056005(MMP2)
CLV: 
102092170(MMP2)
ASN: 
102372370(MMP2)
AMJ: 
102574302(MMP2)
PSS: 
102463152(MMP2)
CMY: 
102946066(MMP2)
ACS: 
100557569(mmp2)
PBI: 
103055844(MMP2)
XLA: 
380389(mmp2)
XTR: 
548506(mmp2)
DRE: 
337179(mmp2)
TRU: 
653022(mmp-2)
MZE: 
OLA: 
100125419(gel-a)
XMA: 
LCM: 
102350008(MMP2)
CMK: 
103176101(mmp2)
CIN: 
ATH: 
ALY: 
CRB: 
 » show all
Taxonomy
Reference
1  [PMID:2994741]
  Authors
Murphy G, McAlpine CG, Poll CT, Reynolds JJ.
  Title
Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen.
  Journal
Biochim. Biophys. Acta. 831 (1985) 49-58.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:2834383]
  Authors
Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI.
  Title
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
  Journal
J. Biol. Chem. 263 (1988) 6579-87.
  Organism
Homo sapiens
  Sequence
[hsa:4313]
Reference
3  [PMID:2269296]
  Authors
Okada Y, Morodomi T, Enghild JJ, Suzuki K, Yasui A, Nakanishi I, Salvesen G, Nagase H.
  Title
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties.
  Journal
Eur. J. Biochem. 194 (1990) 721-30.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
146480-35-5

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