KEGG   ENZYME: 3.4.24.29Help
Entry
EC 3.4.24.29                Enzyme                                 

Name
aureolysin;
Staphylococcus aureus neutral proteinase;
Staphylococcus aureus neutral protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus
Comment
A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen).
History
EC 3.4.24.29 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.29
Orthology
K01401  
aureolysin
Genes
SAU: 
SA2430(aur)
SAV: 
SAV2637(aur)
SAW: 
SAH: 
SAJ: 
SAM: 
MW2558(aur)
SAS: 
SAR: 
SAR2716(aur)
SAC: 
SAX: 
SAA: 
SAO: 
SAE: 
SAD: 
SUU: 
SUV: 
SUH: 
SUE: 
SUJ: 
SUK: 
SUC: 
SUT: 
SUQ: 
SUZ: 
SUD: 
SUX: 
SUW: 
SUG: 
SUF: 
SAUA: 
SAUE: 
SAUN: 
SAUS: 
SAUU: 
SAUZ: 
SAB: 
SUY: 
SAUB: 
SAUM: 
SAUC: 
SAUR: 
SAUI: 
SAUT: 
SAUJ: 
SAUK: 
SAUQ: 
SAUV: 
SAUW: 
SAUX: 
SAUY: 
SEP: 
SER: 
SERP2252(sepA)
SEPP: 
SSP: 
SSD: 
SDT: 
SWA: 
SPAS: 
SXY: 
SXL: 
MCL: 
LMT: 
LMG: 
LMS: 
LMJ: 
LMQ: 
LML: 
LMP: 
LMW: 
LMX: 
LMZ: 
LMON: 
LMOC: 
LMOS: 
LMOO: 
LMOY: 
LMOT: 
LMOA: 
LMOL: 
LMOG: 
LMOE: 
LMOB: 
LMOJ: 
LMOZ: 
LMOD: 
LMOW: 
LMOX: 
LMOQ: 
LMR: 
LSG: 
LIW: 
 » show all
Taxonomy
Reference
1  [PMID:4632563]
  Authors
Arvidson S.
  Title
Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease.
  Journal
Biochim. Biophys. Acta. 302 (1973) 149-57.
Reference
2  [PMID:823980]
  Authors
Saheb SA.
  Title
[Purification and characterization of an extracellular protease from Staphylococcus aureus inhibited by EDTA]
  Journal
Biochimie. 58 (1976) 793-804.
Reference
3  [PMID:711676]
  Authors
Drapeau GR.
  Title
Role of metalloprotease in activation of the precursor of staphylococcal protease.
  Journal
J. Bacteriol. 136 (1978) 607-13.
Reference
4  [PMID:2512988]
  Authors
Potempa J, Porwit-Bobr Z, Travis J.
  Title
Stabilization vs. degradation of Staphylococcus aureus metalloproteinase.
  Journal
Biochim. Biophys. Acta. 993 (1989) 301-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39335-13-2

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