KEGG   ENZYME: 3.4.24.29Help
Entry
EC 3.4.24.29                Enzyme                                 
Name
aureolysin;
Staphylococcus aureus neutral proteinase;
Staphylococcus aureus neutral protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus
Comment
A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymatic activator of plasminogen).
Orthology
K01401  
aureolysin
Genes
SAU: 
SA2430(aur)
SAV: 
SAV2637(aur)
SAW: 
SAH: 
SAJ: 
SAM: 
MW2558(aur)
SAS: 
SAR: 
SAR2716(aur)
SAC: 
SAX: 
SAA: 
SAUSA300_2572(aur)
SAO: 
SAOUHSC_02971
SAE: 
NWMN_2536(aur)
SAD: 
SAAV_2706(aur)
SUU: 
M013TW_2618
SUV: 
SAVC_12065
SUH: 
SAMSHR1132_24610
SUE: 
SAOV_2686c
SUJ: 
SAA6159_02533(aur)
SUK: 
SAA6008_02696(aur)
SUC: 
ECTR2_2491
SUT: 
SAT0131_02903(cspA)
SUQ: 
HMPREF0772_10550(aur)
SUZ: 
MS7_2642(aur)
SUD: 
ST398NM01_2687
SUX: 
SAEMRSA15_25420(aur)
SUW: 
SATW20_27750(aur)
SUG: 
SAPIG2687
SUF: 
SARLGA251_24090(aur)
SAB: 
SAB2512c(aur)
SUY: 
SA2981_2576(aur)
SAUB: 
C248_2705(aur)
SAUM: 
BN843_26750
SEP: 
SE2219
SER: 
SERP2252(sepA)
SSP: 
SSP1542
SSD: 
SPSINT_2146
SDT: 
SPSE_0326
SWA: 
A284_01205
LMT: 
LMRG_02625
LMG: 
LMKG_02772
LMS: 
LMLG_2382
LMJ: 
LMOG_03052
LMQ: 
LMM7_0224(mpl)
LML: 
lmo4a_0219(mpl)
LMP: 
MUO_01160
LMW: 
LMOSLCC2755_0202(mpl)
LMX: 
LMOSLCC2372_0204(mpl)
LMZ: 
LMOSLCC2482_0203(mpl)
LMON: 
LMOSLCC2376_0174(mpl)
LMOC: 
LMOSLCC5850_0197(mpl)
LMOS: 
LMOSLCC7179_0197(mpl)
LMOO: 
LMOSLCC2378_0216(mpl)
LMOY: 
LMOSLCC2479_0203(mpl)
LMOT: 
LMOSLCC2540_0206(mpl)
LMOA: 
LMOATCC19117_0211(mpl)
LMOL: 
LMOL312_0201(mpl)
LMOG: 
BN389_02170(mpl)
LMOE: 
BN418_0213
LMOB: 
BN419_0217
LSG: 
lse_0185(mpl)
MCL: 
MCCL_1675
 » show all
Taxonomy
Reference
1  [PMID:4632563]
  Authors
Arvidson S.
  Title
Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease.
  Journal
Biochim. Biophys. Acta. 302 (1973) 149-57.
  Organism
Staphylococcus aureus
Reference
2  [PMID:823980]
  Authors
Saheb SA.
  Title
[Purification and characterization of an extracellular protease from Staphylococcus aureus inhibited by EDTA]
  Journal
Biochimie. 58 (1976) 793-804.
  Organism
Staphylococcus aureus
Reference
3  [PMID:711676]
  Authors
Drapeau GR.
  Title
Role of metalloprotease in activation of the precursor of staphylococcal protease.
  Journal
J. Bacteriol. 136 (1978) 607-13.
  Organism
Staphylococcus aureus
Reference
4  [PMID:2512988]
  Authors
Potempa J, Porwit-Bobr Z, Travis J.
  Title
Stabilization vs. degradation of Staphylococcus aureus metalloproteinase.
  Journal
Biochim. Biophys. Acta. 993 (1989) 301-4.
  Organism
Staphylococcus aureus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39335-13-2
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