KEGG   ENZYME: 3.4.24.30Help
Entry
EC 3.4.24.30                Enzyme                                 

Name
coccolysin;
Streptococcus thermophilus intracellular proteinase;
EM 19000
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: !Leu, !Phe, !Tyr, !Ala
Comment
A 30 kDa endopeptidase found intracellularly in S. thermophilus [1] and S. diacetilactis [2] and in the medium of S. faecalis [3,4]. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4
History
EC 3.4.24.30 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.30
Orthology
K08605  
coccolysin
Genes
EFA: 
EFL: 
EF62_2189(gelE)
EFI: 
EFD: 
Taxonomy
Reference
1  [PMID:4451671]
  Authors
Desmazeaud MJ.
  Title
[General properties and specificity of action of a neutral intracellular endopeptidase from Streptococcus thermophilus]
  Journal
Biochimie. 56 (1974) 1173-81.
  Organism
Streptococcus thermophilus
Reference
2
  Authors
Desmazeaud, M.J. and Zevaco, C.
  Title
General properties and substrate specificity of an intracellular neutral protease from Streptococcus diacetilactis.
  Journal
Ann. Biol. Anim. Biochem. Biophys. 16 (1976) 851-868.
Reference
3  [PMID:6779709]
  Authors
Smith RA, Green J, Kopper PH.
  Title
The purification and properties of a fibrinolytic neutral metalloendopeptidase from Streptococcus faecalis.
  Journal
Arch. Biochem. Biophys. 202 (1980) 629-38.
  Organism
Streptococcus faecalis
Reference
4  [PMID:2536744]
  Authors
Makinen PL, Clewell DB, An F, Makinen KK.
  Title
Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10).
  Journal
J. Biol. Chem. 264 (1989) 3325-34.
  Organism
Streptococcus faecalis
  Sequence
[efa:EF1818]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
156859-08-4

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