KEGG   ENZYME: 3.4.24.34Help
Entry
EC 3.4.24.34                Enzyme                                 
Name
neutrophil collagenase;
matrix metalloproteinase 8;
PMNL collagenase;
MMP-8
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I
Comment
Similar to interstitial collagenase in specificity, but the product of a different gene and highly glycosylated. Stored in the specific granules of neutrophil leukocytes. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.7
Orthology
K01402  
matrix metalloproteinase-8 (neutrophil collagenase)
Genes
HSA: 
4317(MMP8)
PTR: 
740516(MMP8)
PPS: 
100967517(MMP8)
GGO: 
101130698(MMP8)
PON: 
100459562(MMP8)
MCC: 
703536(MMP8)
MMU: 
17394(Mmp8)
RNO: 
63849(Mmp8)
CFA: 
489429(MMP8)
AML: 
100480934(MMP8)
FCA: 
101080995(MMP8)
BTA: 
100336575(MMP8)
SSC: 
100523811(MMP8)
ECB: 
100069005(MMP8)
MDO: 
100012425
SHR: 
100914807(MMP8)
OAA: 
100079007
 » show all
Taxonomy
Reference
1  [PMID:3038863]
  Authors
Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG.
  Title
The collagen substrate specificity of human neutrophil collagenase.
  Journal
J. Biol. Chem. 262 (1987) 10048-52.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:2164002]
  Authors
Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL.
  Title
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
  Journal
J. Biol. Chem. 265 (1990) 11421-4.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:2159879]
  Authors
Knauper V, Kramer S, Reinke H, Tschesche H.
  Title
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms.
  Journal
Eur. J. Biochem. 189 (1990) 295-300.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-12-1
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