KEGG   ENZYME: 3.4.24.35Help
Entry
EC 3.4.24.35                Enzyme                                 
Name
gelatinase B;
92-kDa gelatinase;
matrix metalloproteinase 9;
type V collagenase;
92-kDa type IV collagenase;
macrophage gelatinase;
95 kDa type IV collagenase/gelatinase;
collagenase IV;
collagenase type IV;
gelatinase MMP 9;
MMP 9;
matrix metalloproteinase 9;
type IV collagen metalloproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of gelatin types I and V and collagen types IV and V
Comment
Similar to gelatinase A, but possesses a further domain . In peptidase family M10 (interstitial collagenase family)
Orthology
K01403  
matrix metalloproteinase-9 (gelatinase B)
Genes
HSA: 
4318(MMP9)
PTR: 
458294(MMP9)
PPS: 
100974722(MMP9)
GGO: 
101138361(MMP9)
PON: 
100455867(MMP9)
MCC: 
708084(MMP9)
MMU: 
17395(Mmp9)
RNO: 
81687(Mmp9)
CFA: 
403885(MMP9)
AML: 
FCA: 
101084185(MMP9)
BTA: 
282871(MMP9)
SSC: 
654325(MMP9)
ECB: 
100056599(MMP9)
MDO: 
100022144
SHR: 
100934566(MMP9)
GGA: 
395387(MMP9)
MGP: 
100540313
TGU: 
100227728(MMP9)
XLA: 
100037129(mmp-9th) 379663(mmp9)
XTR: 
100494738 448591(mmp9)
DRE: 
406397(mmp9)
TRU: 
653023(mmp-9)
OLA: 
100125420(gel-b)
 » show all
Taxonomy
Reference
1  [PMID:3680518]
  Authors
Hibbs MS, Hoidal JR, Kang AH.
  Title
Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages.
  Journal
J. Clin. Invest. 80 (1987) 1644-50.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:2551898]
  Authors
Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI.
  Title
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
  Journal
J. Biol. Chem. 264 (1989) 17213-21.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:2165210]
  Authors
Mainardi CL, Hasty KA.
  Title
Secretion and glycosylation of rabbit macrophage type V collagenase.
  Journal
Matrix. 10 (1990) 84-90.
  Organism
Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
146480-36-6
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