KEGG   ENZYME: 3.4.24.36Help
Entry
EC 3.4.24.36                Enzyme                                 

Name
leishmanolysin;
promastigote surface endopeptidase;
glycoprotein gp63;
Leishmania metalloproteinase;
surface acid proteinase;
promastigote surface protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr!Leu-Lys-Lys-
Comment
A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100!Val bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family M8
History
EC 3.4.24.36 created 1992
Orthology
K01404  
leishmanolysin
Genes
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os03t0731500-01(Os03g0731500)
OBR: 
BDI: 
SBI: 
SORBI_01g009170(SORBIDRAFT_01g009170)
ZMA: 
SITA: 
PDA: 
ATR: 
s00059p00146300(AMTR_s00059p00146300)
PPP: 
DDI: 
DPP: 
DFA: 
DFA_06007(sigB)
EHI: 
EHI_042870(111.t00003) EHI_200230(30.t00006)
EDI: 
ACAN: 
TPS: 
PIF: 
EHX: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
 » show all
Taxonomy
Reference
1  [PMID:3346625]
  Authors
Button LL, McMaster WR.
  Title
Molecular cloning of the major surface antigen of leishmania.
  Journal
J. Exp. Med. 167 (1988) 724-9.
  Sequence
Reference
2  [PMID:2608099]
  Authors
Bouvier J, Bordier C, Vogel H, Reichelt R, Etges R.
  Title
Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase.
  Journal
Mol. Biochem. Parasitol. 37 (1989) 235-45.
Reference
3  [PMID:2708373]
  Authors
Chaudhuri G, Chaudhuri M, Pan A, Chang KP.
  Title
Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages.
  Journal
J. Biol. Chem. 264 (1989) 7483-9.
Reference
4  [PMID:2271643]
  Authors
Bouvier J, Schneider P, Etges R, Bordier C.
  Title
Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania.
  Journal
Biochemistry. 29 (1990) 10113-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
161052-06-8

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