KEGG   ENZYME: 3.4.24.36Help
Entry
EC 3.4.24.36                Enzyme                                 
Name
leishmanolysin;
promastigote surface endopeptidase;
glycoprotein gp63;
Leishmania metalloproteinase;
surface acid proteinase;
promastigote surface protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr!Leu-Lys-Lys-
Comment
A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100!Val bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family M8
Orthology
K01404  
leishmanolysin
Genes
ATH: 
ALY: 
GMX: 
CSV: 
RCU: 
POP: 
VVI: 
OSA: 
DOSA: 
Os03t0731500-01(Os03g0731500)
BDI: 
SBI: 
SORBI_01g009170(SORBIDRAFT_01g009170)
PPP: 
PHYPADRAFT_132950
NGR: 
NAEGRDRAFT_74654
DDI: 
DDB_G0286533
DPP: 
DICPUDRAFT_57749
EHI: 
EHI_042870(111.t00003) EHI_200230(30.t00006)
EDI: 
EDI_037980
TBR: 
Tb10.70.5290 Tb11.02.5310 Tb11.02.5610 Tb11.02.5630 Tb11.02.5640 Tb11.12.0006 Tb927.8.1610(Tb08.29O9.350) Tb927.8.1620(Tb08.29O9.360) Tb927.8.1630(Tb08.29O9.370) Tb927.8.1640(Tb08.29O9.380)
TCR: 
410797.10 505615.10 505989.70 506145.80 506257.50 506321.240 506401.380 506867.40 507917.10 507919.10 507993.350 508241.50 508545.40 508609.10 508611.30 508693.100 508699.100 508999.170 509011.80 509205.100 510263.30 510565.150 510657.200 510747.40 510761.80 510873.20 510899.10 511035.10 511151.54 511203.20 511257.60 511277.610 511281.50 511723.10
LMA: 
LMJF_10_0460(GP63-1) LMJF_10_0465(GP63-2) LMJF_10_0470(GP63-3) LMJF_10_0480(GP63-4) LMJF_28_0570 LMJF_31_2000
LIF: 
LINJ_10_0490(GP63-1) LINJ_10_0500(GP63-2) LINJ_10_0510(GP63-3) LINJ_10_0520(GP63-3) LINJ_10_0530(GP63-4) LINJ_28_0600 LINJ_28_0610 LINJ_31_2040
LDO: 
LDBPK_280600 LDBPK_312040
LMI: 
LMXM_10_0390 LMXM_10_0405 LMXM_10_0460 LMXM_10_0470 LMXM_28_0570 LMXM_30_2000
LBZ: 
LBRM_10_0470(GP63-1) LBRM_10_0480(GP63-2) LBRM_10_0500 LBRM_10_0510(GP63-3) LBRM_10_0520 LBRM_10_0540 LBRM_10_0550(GP63-2) LBRM_10_0560(GP63-4) LBRM_10_0570(GP63-4) LBRM_10_0580(GP63-4) LBRM_10_0590 LBRM_10_0600 LBRM_10_0610 LBRM_31_2260
TVA: 
TVAG_018910
TPS: 
THAPS_263268
PIF: 
PITG_08774
 » show all
Taxonomy
Reference
1  [PMID:3346625]
  Authors
Button LL, McMaster WR.
  Title
Molecular cloning of the major surface antigen of leishmania.
  Journal
J. Exp. Med. 167 (1988) 724-9.
  Organism
Leishmania major [GN:lma], Leishmania donovani
Reference
2  [PMID:2608099]
  Authors
Bouvier J, Bordier C, Vogel H, Reichelt R, Etges R.
  Title
Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase.
  Journal
Mol. Biochem. Parasitol. 37 (1989) 235-45.
  Organism
Leishmania major [GN:lma]
Reference
3  [PMID:2708373]
  Authors
Chaudhuri G, Chaudhuri M, Pan A, Chang KP.
  Title
Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages.
  Journal
J. Biol. Chem. 264 (1989) 7483-9.
  Organism
Leishmania mexicana
Reference
4  [PMID:2271643]
  Authors
Bouvier J, Schneider P, Etges R, Bordier C.
  Title
Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania.
  Journal
Biochemistry. 29 (1990) 10113-9.
  Organism
Leishmania major [GN:lma], Leishmania amazonensis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
161052-06-8
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