KEGG   ENZYME: 3.4.24.38Help
Entry
EC 3.4.24.38                Enzyme                                 

Name
gametolysin;
autolysin, Chlamydomonas cell wall degrading protease;
lysin;
Chlamydomonas reinhardtii metalloproteinase;
gamete lytic enzyme;
gamete autolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of the proline- and hydroxyproline-rich proteins of the Chlamydomonas cell wall; also cleaves azocasein, gelatin and Leu-Trp-Met!Arg-Phe-Ala
Comment
A glycoprotein found in the periplasmic space of Chlamydomonas reinhardtii gametes in a 62 kDa inactive form; decreased to 60 kDa upon activation. A zinc enzyme, inhibited by phosphoramidon, but also thiol activated. Type example of peptidase family M11
History
EC 3.4.24.38 created 1992, modified 2000
Reference
1  [PMID:3319620]
  Authors
Jaenicke L, Kuhne W, Spessert R, Wahle U, Waffenschmidt S.
  Title
Cell-wall lytic enzymes (autolysins) of Chlamydomonas reinhardtii are (hydroxy)proline-specific proteases.
  Journal
Eur. J. Biochem. 170 (1987) 485-91.
Reference
2  [PMID:2910877]
  Authors
Buchanan MJ, Imam SH, Eskue WA, Snell WJ.
  Title
Activation of the cell wall degrading protease, lysin, during sexual signalling in Chlamydomonas: the enzyme is stored as an inactive, higher relative molecular mass precursor in the periplasm.
  Journal
J. Cell. Biol. 108 (1989) 199-207.
Reference
3
  Authors
Matsuda, Y.
  Title
Gametolysin.
  Journal
In: Barrett, A.J., Rawlings, N.D. & Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1140-1143.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-74-2

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