| Entry |
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| Name |
serralysin;
Pseudomonas aeruginosa alkaline proteinase;
Escherichia freundii proteinase;
Serratia marcescens extracellular proteinase;
Serratia marcescens metalloproteinase;
Pseudomonas aeruginosa alk. protease;
Serratia marcescens metalloprotease
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Preferential cleavage of bonds with hydrophobic residues in P1'
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| Comment |
A 50 kDa extracellular endopeptidase from Pseudomonas aeruginosa [1,2,6], Escherichia freundii [3], Serratia marcescens [4,5,6] and Erwinia chrysanthemi [7]. There is broad specificity in cleavage of the insulin B chain, with some species variations. The pH optimum for digesting various proteins is about 9 - 10. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.4
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| Orthology |
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| Genes |
YPP: | | SPE: | | PSB: | | PFL: | | PEN: | | PMY: | | RSH: | | MMR: | | AVA: | |
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| Reference |
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| Authors |
Morihara K, Tsuzuki H, Oka T. |
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| Title |
Comparison of the specificities of various neutral proteinases from microorganisms. |
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| Journal |
Arch. Biochem. Biophys. 123 (1968) 572-88. |
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| Reference |
|
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| Authors |
Morihara K, Tsuzuki H, Oka T. |
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| Title |
On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides. |
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| Journal |
Biochim. Biophys. Acta. 309 (1973) 414-29. |
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| Organism |
Pseudomonas aeruginosa |
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| Reference |
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| Authors |
Nakajima M, Mizusawa K, Yoshida F. |
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| Title |
Purification and properties of an extracellular proteinase of psychrophilic Escherichia freundii. |
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| Journal |
Eur. J. Biochem. 44 (1974) 87-96. |
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| Organism |
Escherichia freundii |
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| Reference |
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| Authors |
Decedue CJ, Broussard EA 2nd, Larson AD, Braymer HD. |
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| Title |
Purification and characterization of the extracellular proteinase of Serratia marcescens. |
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| Journal |
Biochim. Biophys. Acta. 569 (1979) 293-301. |
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| Organism |
Serratia marcescens |
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| Reference |
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| Authors |
Doerr M, Traub WH. |
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| Title |
Purification and characterization of two Serratia marcescens proteases. |
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| Journal |
Zentralbl. Bakteriol. Mikrobiol. Hyg. [A]. 257 (1984) 6-19. |
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| Organism |
Serratia marcescens |
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| Reference |
|
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| Authors |
Nakahama K, Yoshimura K, Marumoto R, Kikuchi M, Lee IS, Hase T, Matsubara H. |
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| Title |
Cloning and sequencing of Serratia protease gene. |
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| Journal |
Nucleic. Acids. Res. 14 (1986) 5843-55. |
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| Organism |
Serratia marcescens |
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| Reference |
|
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| Authors |
Dahler GS, Barras F, Keen NT. |
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| Title |
Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16. |
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| Journal |
J. Bacteriol. 172 (1990) 5803-15. |
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| Organism |
Erwinia chrysanthemi |
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| Reference |
|
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| Authors |
Okuda K, Morihara K, Atsumi Y, Takeuchi H, Kawamoto S, Kawasaki H, Suzuki K, Fukushima J. |
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| Title |
Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455. |
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| Journal |
Infect. Immun. 58 (1990) 4083-8. |
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| Organism |
Pseudomonas aeruginosa |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 70851-98-8 |
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