KEGG   ENZYME: 3.4.24.45Help
Entry
EC 3.4.24.45                Enzyme                                 

Name
atrolysin F;
Crotalus atrox metalloendopeptidase;
hemorrhagic toxin f;
Crotalus atrox metalloendopeptidase f
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Val2!Asn, Gln4!His, Leu6!Cys, His10!Leu, Ala14!Leu and Tyr16!Leu bonds in insulin B chain
Comment
A 64 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests the gamma chain of fibrinogen. Immunologically distinct from EC 3.4.24.1, atrolysin A.
History
EC 3.4.24.45 created 1992
Reference
1  [PMID:6375570]
  Authors
Nikai T, Mori N, Kishida M, Sugihara H, Tu AT.
  Title
Isolation and biochemical characterization of hemorrhagic toxin f from the venom of Crotalus atrox (western diamondback rattlesnake).
  Journal
Arch. Biochem. Biophys. 231 (1984) 309-19.
  Organism
Crotalus atrox
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
172306-52-4

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