KEGG   ENZYME: 3.4.24.46Help
Entry
EC 3.4.24.46                Enzyme                                 

Name
adamalysin;
Crotalus adamanteus metalloendopeptidase;
proteinase I and II;
Crotalus adamanteus venom proteinase II;
adamalysin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Phe1!Val, His5!Leu, His10!Leu, Ala14!Leu, Leu15!Tyr, and Tyr16!Leu of insulin B chain
Comment
From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate alpha1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family)
History
EC 3.4.24.46 created 1992
Reference
1  [PMID:309470]
  Authors
Kurecki T, Laskowski M Sr, Kress LF.
  Title
Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor.
  Journal
J. Biol. Chem. 253 (1978) 8340-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
74812-51-4

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