| Entry |
|
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| Name |
adamalysin;
Crotalus adamanteus metalloendopeptidase;
proteinase I and II;
Crotalus adamanteus venom proteinase II;
adamalysin II
|
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
 |
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| Reaction(IUBMB) |
Cleavage of Phe1!Val, His5!Leu, His10!Leu, Ala14!Leu, Leu15!Tyr, and Tyr16!Leu of insulin B chain
|
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| Comment |
From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate alpha1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family)
|
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| Reference |
|
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| Authors |
Kurecki T, Laskowski M Sr, Kress LF. |
|---|
| Title |
Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor. |
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| Journal |
J. Biol. Chem. 253 (1978) 8340-5. |
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| Organism |
Crotalus adamanteus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 74812-51-4 |
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