KEGG   ENZYME: 3.4.24.48Help
Entry
EC 3.4.24.48                Enzyme                                 

Name
ruberlysin;
Crotalus ruber metalloendopeptidase II;
hemorrhagic toxin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe bonds in the B chain of insulin; His!Pro, Pro!Phe, and Trp!Ser of angiotensin I; and Gly!Phe of Met enkephalin
Comment
A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family)
History
EC 3.4.24.48 created 1992
Reference
1  [PMID:2949699]
  Authors
Mori N, Nikai T, Sugihara H, Tu AT.
  Title
Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom.
  Journal
Arch. Biochem. Biophys. 253 (1987) 108-21.
  Organism
Crotalus ruber ruber
Reference
2  [PMID:2081731]
  Authors
Takeya H, Onikura A, Nikai T, Sugihara H, Iwanaga S.
  Title
Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber.
  Journal
J. Biochem. (Tokyo). 108 (1990) 711-9.
  Organism
Crotalus ruber ruber
  Sequence
[up:P20897]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
846020-01-7

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