KEGG   ENZYME: 3.4.24.50Help
Entry
EC 3.4.24.50                Enzyme                                 

Name
bothrolysin;
Bothrops metalloendopeptidase J;
J protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Gln4!His, Ser9!His and Ala14!Leu of insulin B chain and Pro!Phe of angiotensin I
Comment
A 22.5 kDa endopeptidase from the venom of the jararaca snake (Bothrops jararaca), insensitive to phosphoramidon at 0.5 mM. In peptidase family M12 (astacin family)
History
EC 3.4.24.50 created 1992
Reference
1  [PMID:2781574]
  Authors
Tanizaki MM, Zingali RB, Kawazaki H, Imajoh S, Yamazaki S, Suzuki K.
  Title
Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca).
  Journal
Toxicon. 27 (1989) 747-55.
  Sequence
[up:P20416]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
443890-65-1

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