KEGG   ENZYME: 3.4.24.52Help
Entry
EC 3.4.24.52                Enzyme                                 

Name
trimerelysin I;
Trimeresurus metalloendopeptidase I;
hemorrhagic proteinase HR1A;
hemorrhagic metalloproteinase HR1A;
metalloproteinase HR1A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of only two bonds His10!Leu and Ala14!Leu in the insulin B chain
Comment
A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family)
History
EC 3.4.24.52 created 1992
Reference
1  [PMID:518906]
  Authors
Omori-Satoh T, Sadahiro S.
  Title
Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts.
  Journal
Biochim. Biophys. Acta. 580 (1979) 392-404.
Reference
2  [PMID:3284004]
  Authors
Yamakawa Y, Omori-Satoh T.
  Title
The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis).
  Journal
Toxicon. 26 (1988) 227-31.
Reference
3  [PMID:2398046]
  Authors
Takeya H, Oda K, Miyata T, Omori-Satoh T, Iwanaga S.
  Title
The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis.
  Journal
J. Biol. Chem. 265 (1990) 16068-73.
  Sequence
[up:P20164]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
151125-16-5

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