insulysin;
insulinase;
insulin-degrading enzyme;
insulin protease;
insulin proteinase;
insulin-degrading neutral proteinase;
insulin-specific protease;
insulin-glucagon protease;
metalloinsulinase;
IDE

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Degradation of insulin, glucagon and other polypeptides. No action on proteins

A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family).

1  [PMID:3061785]

Duckworth WC.

Insulin degradation: mechanisms, products, and significance.

Endocr. Rev. 9 (1988) 319-45.

2  [PMID:2293021]

Affholter JA, Hsieh CL, Francke U, Roth RA.

Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.

Mol. Endocrinol. 4 (1990) 1125-35.

Homo sapiens [GN:hsa]

3  [PMID:1689296]

Duckworth WC, Hamel FG, Bennett R, Ryan MP, Roth RA.

Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin.

J. Biol. Chem. 265 (1990) 2984-7.

Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]

4  [PMID:2126597]

Kuo WL, Gehm BD, Rosner MR.

Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.

Mol. Endocrinol. 4 (1990) 1580-91.

Homo sapiens [GN:hsa]

5  [PMID:1733942]

Ding L, Becker AB, Suzuki A, Roth RA.

Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III.

J. Biol. Chem. 267 (1992) 2414-20.

Homo sapiens [GN:hsa]