KEGG   ENZYME: 3.4.24.58Help
Entry
EC 3.4.24.58                Enzyme                                 

Name
russellysin;
Russell's viper venom factor X activator, RVV-X;
blood-coagulation factor X activating enzyme;
metalloproteinase RVV-x;
Vipera russelli proteinase;
Russell's viper blood coagulation factor X activator;
RVV-V
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg! bonds. Has no action on insulin B chain
Comment
This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family)
History
EC 3.4.24.58 created 1993
Reference
1  [PMID:1011991]
  Authors
Furie BC, Furie B.
  Title
Coagulant protein of Russell's viper venom.
  Journal
Methods. Enzymol. 45 (1976) 191-205.
  Organism
Vipera russelli
Reference
2  [PMID:632245]
  Authors
Lindquist PA, Fujikawa K, Davie EW.
  Title
Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom.
  Journal
J. Biol. Chem. 253 (1978) 1902-9.
  Organism
Vipera russelli
Reference
3  [PMID:1629211]
  Authors
Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S.
  Title
Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains.
  Journal
J. Biol. Chem. 267 (1992) 14109-17.
  Organism
Vipera russelli
  Sequence
[up: Q7LZ61]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
79393-92-3

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