KEGG   ENZYME: 3.4.24.63Help
Entry
EC 3.4.24.63                Enzyme                                 

Name
meprin B;
meprin-b
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain
Comment
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)
History
EC 3.4.24.63 created 1995
Orthology
K08606  
meprin B
Genes
HSA: 
4225(MEP1B)
PTR: 
468515(MEP1B)
PPS: 
100991143(MEP1B)
GGO: 
PON: 
100461703(MEP1B)
NLE: 
100587715(MEP1B)
MCC: 
707036(MEP1B)
MCF: 
102120570(MEP1B)
CJC: 
100406280(MEP1B)
MMU: 
17288(Mep1b)
RNO: 
25727(Mep1b)
CGE: 
100774490(Mep1b)
HGL: 
101721966(Mep1b)
TUP: 
102501249(MEP1B)
CFA: 
490497(MEP1B)
AML: 
100474827(MEP1B)
UMR: 
103665002(MEP1B)
FCA: 
101089149(MEP1B)
PTG: 
102972887(MEP1B)
BTA: 
540701(MEP1B)
BOM: 
102277511(MEP1B)
PHD: 
102342891(MEP1B)
CHX: 
102181352(MEP1B)
OAS: 
101114072(MEP1B)
SSC: 
100516141(MEP1B)
CFR: 
102509020(MEP1B)
BACU: 
102999400(MEP1B)
LVE: 
103090304(MEP1B)
ECB: 
100052389(MEP1B)
MYB: 
102262211(MEP1B)
MYD: 
102761324(MEP1B)
PALE: 
102878505(MEP1B)
MDO: 
SHR: 
OAA: 
100084811(MEP1B)
GGA: 
421097(MEP1B)
MGP: 
100545010(MEP1B)
APLA: 
101794200(MEP1B)
TGU: 
100227825(MEP1B)
FAB: 
101820401(MEP1B)
PHI: 
102106845(MEP1B)
FPG: 
101920674(MEP1B)
FCH: 
102052375(MEP1B)
CLV: 
102096310(MEP1B)
ASN: 
102371434(MEP1B)
AMJ: 
102574106(MEP1B)
PSS: 
102456515(MEP1B)
CMY: 
102938685(MEP1B)
ACS: 
100563868(mep1b)
PBI: 
103049257(MEP1B)
XTR: 
100124942(mep1b)
DRE: 
100151009(mep1b) 327586(fi19a06)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103191077(mep1b)
CIN: 
LGI: 
NVE: 
HMG: 
 » show all
Taxonomy
Reference
1  [PMID:1894622]
  Authors
Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.
  Title
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
  Journal
J. Biol. Chem. 266 (1991) 17350-7.
  Sequence
[mmu:17288]
Reference
2  [PMID:8407940]
  Authors
Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.
  Title
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.
  Journal
J. Biol. Chem. 268 (1993) 21035-43.
  Sequence
[mmu:17288]
Reference
3  [PMID:7510289]
  Authors
Johnson GD, Hersh LB.
  Title
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.
  Journal
J. Biol. Chem. 269 (1994) 7682-8.
Reference
4  [PMID:7674930]
  Authors
Wolz RL, Bond JS.
  Title
Meprins A and B.
  Journal
Methods. Enzymol. 248 (1995) 325-45.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
150679-52-0

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