KEGG   ENZYME: 3.4.24.7Help
Entry
EC 3.4.24.7                 Enzyme                                 
Name
interstitial collagenase;
vertebrate collagenase;
matrix metalloproteinase 1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775!Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue
Comment
The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, alpha-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10
Orthology
K01388  
matrix metalloproteinase-1 (interstitial collagenase)
Genes
HSA: 
4312(MMP1)
PTR: 
451510(MMP1)
PPS: 
GGO: 
101131051(MMP1)
PON: 
100459931(MMP1)
MCC: 
703653(MMP1)
MMU: 
83995(Mmp1a) 83996(Mmp1b)
RNO: 
300338(Mmp1b) 300339(Mmp1)
CFA: 
489428(MMP1)
AML: 
FCA: 
101084217
BTA: 
100848085 281308(MMP1)
SSC: 
397320(MMP1)
ECB: 
100033896(MMP1)
MDO: 
100012472(MMP1)
SHR: 
100915062(MMP1)
OAA: 
100078975
GGA: 
418982(MMP1)
MGP: 
100543241
TGU: 
100218575(MMP1)
ACS: 
100552848
XLA: 
495287(mmp1)
XTR: 
594916(mmp1)
 » show all
Taxonomy
Reference
1  [PMID:3009463]
  Authors
Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ.
  Title
Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.
  Journal
J. Biol. Chem. 261 (1986) 6600-5.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:3041177]
  Authors
Birkedal-Hansen H.
  Title
Catabolism and turnover of collagens: collagenases.
  Journal
Methods. Enzymol. 144 (1987) 140-71.
Reference
3  [PMID:3032960]
  Authors
Fields GB, Van Wart HE, Birkedal-Hansen H.
  Title
Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site.
  Journal
J. Biol. Chem. 262 (1987) 6221-6.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:2462561]
  Authors
Sottrup-Jensen L, Birkedal-Hansen H.
  Title
Human fibroblast collagenase-alpha-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins.
  Journal
J. Biol. Chem. 264 (1989) 393-401.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-12-1
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