pappalysin-1;
insulin-like growth factor binding protein-4 protease;
pregnancy-associated plasma protein-A

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Cleavage of the Met135!Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143!Lys bond in IGFBP-5

A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43.

1  [PMID:10077652]

Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR 3rd, Conover CA.

The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.

Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3149-53.

Homo sapiens [GN:hsa]

2  [PMID:11897673]

Chen BK, Overgaard MT, Bale LK, Resch ZT, Christiansen M, Oxvig C, Conover CA.

Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor.

Endocrinology. 143 (2002) 1199-205.

Homo sapiens [GN:hsa]