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Entry
EC 3.4.24.79                Enzyme                                 

Name
pappalysin-1;
insulin-like growth factor binding protein-4 protease;
pregnancy-associated plasma protein-A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of the Met135!Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143!Lys bond in IGFBP-5
Comment
A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43.
History
EC 3.4.24.79 created 2003
Orthology
K07762  
pappalysin-1
Genes
HSA: 
5069(PAPPA)
PTR: 
464690(PAPPA)
PPS: 
100989941(PAPPA)
GGO: 
101151353(PAPPA)
PON: 
100454210(PAPPA)
NLE: 
100599572(PAPPA)
MCC: 
706783(PAPPA)
MCF: 
102116695(PAPPA)
CJC: 
100415163(PAPPA)
MMU: 
18491(Pappa)
RNO: 
313262(Pappa)
CGE: 
100764393(Pappa)
HGL: 
101725271(Pappa)
TUP: 
102480063(PAPPA)
CFA: 
481692(PAPPA)
AML: 
100477297(PAPPA)
UMR: 
103670499(PAPPA)
FCA: 
101089154(PAPPA)
PTG: 
102961547(PAPPA)
BTA: 
282647(PAPPA)
BOM: 
102283218(PAPPA)
PHD: 
102322695(PAPPA)
CHX: 
102179947(PAPPA)
OAS: 
443157(PAPP-A)
SSC: 
397219(PAPP-A)
CFR: 
102522604(PAPPA)
BACU: 
103018301(PAPPA)
LVE: 
103074012(PAPPA)
ECB: 
100033920(PAPP-A)
MYB: 
102257568(PAPPA)
MYD: 
102755027(PAPPA)
PALE: 
102898449(PAPPA)
MDO: 
100014138(PAPPA)
SHR: 
100925831(PAPPA)
OAA: 
100077262(PAPPA)
GGA: 
417245(PAPPA)
APLA: 
101793026(PAPPA)
TGU: 
100232076(PAPPA)
FAB: 
101821477(PAPPA)
PHI: 
102100804(PAPPA)
FPG: 
101917201(PAPPA)
FCH: 
102056110(PAPPA)
CLV: 
102097499(PAPPA)
ASN: 
102384442(PAPPA)
AMJ: 
102571651(PAPPA)
PSS: 
102447252(PAPPA)
CMY: 
102941026(PAPPA)
ACS: 
PBI: 
103050788(PAPPA)
XTR: 
100495014(pappa)
DRE: 
101448000(pappaa) 101448001(pappab)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102365919(PAPPA)
CMK: 
103180420(pappa)
BFO: 
SPU: 
ISC: 
LOA: 
TSP: 
LGI: 
NVE: 
TAD: 
ANI: 
 » show all
Taxonomy
Reference
1  [PMID:10077652]
  Authors
Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR 3rd, Conover CA.
  Title
The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3149-53.
  Sequence
[hsa:5069]
Reference
2  [PMID:11897673]
  Authors
Chen BK, Overgaard MT, Bale LK, Resch ZT, Christiansen M, Oxvig C, Conover CA.
  Title
Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor.
  Journal
Endocrinology. 143 (2002) 1199-205.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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