KEGG   ENZYME: 3.4.24.80Help
Entry
EC 3.4.24.80                Enzyme                                 

Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
History
EC 3.4.24.80 created 2003
Orthology
K07763  matrix metalloproteinase-14 (membrane-inserted)
Genes
HSA: 4323(MMP14)
PTR: 742887(MMP14)
PPS: 100990208(MMP14)
GGO: 101142469(MMP14)
PON: 100171646(MMP14)
NLE: 100606407(MMP14)
MCC: 712429(MMP14)
MCF: 102132205(MMP14)
CSAB: 103231446(MMP14)
RRO: 104674133(MMP14)
RBB: 108523596(MMP14)
CJC: 100389088(MMP14)
SBQ: 101041075(MMP14)
MMU: 17387(Mmp14)
RNO: 81707(Mmp14)
CGE: 100689336(Mmp14)
NGI: 103739479(Mmp14)
HGL: 101723795(Mmp14)
CCAN: 109685808(Mmp14) 109689717
OCU: 100009598(MMP14)
TUP: 102468813(MMP14)
CFA: 403823(MMP14)
AML: 100468621(MMP14)
UMR: 103681059(MMP14)
ORO: 101369821(MMP14)
FCA: 101089776(MMP14)
PTG: 102953674(MMP14)
AJU: 106988210(MMP14)
BTA: 281915(MMP14)
BOM: 102281987(MMP14)
BIU: 109564819(MMP14)
PHD: 102321416(MMP14)
CHX: 100861171(MMP14)
OAS: 443116(MMP14)
SSC: 397471(MMP14)
CFR: 102513570 102524386(MMP14)
CDK: 105096970(MMP14)
BACU: 103003307(MMP14)
LVE: 103081188(MMP14)
OOR: 101284790(MMP14)
ECB: 100034170(MMP14)
EPZ: 103556751(MMP14)
EAI: 106840662(MMP14)
MYB: 102240202(MMP14)
MYD: 102761559(MMP14)
HAI: 109393698(MMP14)
RSS: 109458321(MMP14)
PALE: 102887003(MMP14)
LAV: 100671131(MMP14)
TMU: 101345768
MDO: 100030382(MMP14)
SHR: 100932143(MMP14)
OAA: 100091029(MMP14)
CJO: 107307506
PHI: 102107021(MMP14)
ASN: 102368749(MMP14)
AMJ: 102558609(MMP14)
CMY: 102943947
CPIC: 101945719(MMP14)
ACS: 100553534(mmp14)
PVT: 110087815(MMP14)
PBI: 103064383(MMP14)
GJA: 107109121(MMP14)
XLA: 108707025 407753(mmp14.L)
XTR: 594950(mmp14)
NPR: 108786770(MMP14)
DRE: 373882(mmp14a) 566945(mmp14b)
AMEX: 103024760(mmp14) 103041213
TRU: 101061607 101073560(mmp14)
LCO: 104927972 104932902(mmp14)
OLA: 100125428(mmp14) 101171699
NFU: 107377284(mmp14) 107384247
CSEM: 103388226(mmp14) 103396588
LCM: 102355301(MMP14)
CIN: 100181633
DME: Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)
DSI: Dsimw501_GD24926(Dsim_GD24926)
MDE: 101888990
AAG: 5566822
AME: 409868
BIM: 100741313
BTER: 100647268
AEC: 105151121
ACEP: 105619997
HST: 105190364
CFO: 105255413
LHU: 105675698
NVI: 100113893(Mmp1)
DPA: 109542402
BMOR: 100144547(Mmp1)
PMAC: 106712426
PXY: 105396373
API: 100164006
TUT: 107367240
 » show all
Taxonomy
Reference
1  [PMID:11532942]
  Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
  Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
  Journal
EMBO. J. 20 (2001) 4782-93.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.80
IUBMB Enzyme Nomenclature: 3.4.24.80
ExPASy - ENZYME nomenclature database: 3.4.24.80
BRENDA, the Enzyme Database: 3.4.24.80
CAS: 161384-17-4

DBGET integrated database retrieval system