KEGG   ENZYME: 3.4.24.80Help
Entry
EC 3.4.24.80                Enzyme                                 
Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
Orthology
K07763  
matrix metalloproteinase-14 (membrane-inserted)
Genes
HSA: 
4323(MMP14)
PTR: 
742887(MMP14)
PPS: 
100990208(MMP14)
GGO: 
101142469(MMP14)
PON: 
100171646(MMP14)
MCC: 
712429(MMP14)
MMU: 
17387(Mmp14)
RNO: 
81707(Mmp14)
CFA: 
403823(MMP14)
AML: 
FCA: 
101089776(MMP14)
BTA: 
281915(MMP14)
SSC: 
397471(MMP14)
ECB: 
100034170(MMP14)
MDO: 
100030382
SHR: 
100932143(MMP14)
OAA: 
100091029
ACS: 
100553534(mmp14)
XLA: 
407753(mmp14)
XTR: 
594950(mmp14)
DRE: 
373882(mmp14a) 566945(mmp14b)
TRU: 
101061607 101073560
OLA: 
100125428(mt1-mmp)
BFO: 
BRAFLDRAFT_264495
DME: 
Dmel_CG4859(Mmp1) Dmel_CG7056
DPO: 
Dpse_GA18484
DAN: 
Dana_GF11910
DER: 
Dere_GG19900
DPE: 
Dper_GL17167
DSE: 
Dsec_GM11800
DSI: 
Dsim_GD24926
DWI: 
Dwil_GK21871
DYA: 
Dyak_GE11424
DGR: 
Dgri_GH21566
DMO: 
Dmoj_GI19538
DVI: 
Dvir_GJ21109
AGA: 
AgaP_AGAP006904
AAG: 
AaeL_AAEL005666
CQU: 
CpipJ_CPIJ010856
AME: 
409868
NVI: 
100113893(Mmp1)
TCA: 
657261(Mmp-1)
API: 
100164006
PHU: 
Phum_PHUM302710
ISC: 
IscW_ISCW006136
NVE: 
NEMVE_v1g166550
 » show all
Taxonomy
Reference
1  [PMID:11532942]
  Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
  Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
  Journal
EMBO. J. 20 (2001) 4782-93.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
161384-17-4
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