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Entry
EC 3.4.24.80                Enzyme                                 

Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
History
EC 3.4.24.80 created 2003
Orthology
K07763  
matrix metalloproteinase-14 (membrane-inserted)
Genes
HSA: 
4323(MMP14)
PTR: 
742887(MMP14)
PPS: 
100990208(MMP14)
GGO: 
101142469(MMP14)
PON: 
100171646(MMP14)
NLE: 
100606407(MMP14)
MCC: 
712429(MMP14)
MCF: 
102132205(MMP14)
CJC: 
100389088(MMP14)
MMU: 
17387(Mmp14)
RNO: 
81707(Mmp14)
CGE: 
100689336(Mmp14)
NGI: 
103739479(Mmp14)
HGL: 
101723795(Mmp14)
OCU: 
100009598(MMP14)
TUP: 
102468813(MMP14)
CFA: 
403823(MMP14)
AML: 
UMR: 
103681059(MMP14)
FCA: 
101089776(MMP14)
PTG: 
102953674(MMP14)
BTA: 
281915(MMP14)
BOM: 
102281987(MMP14)
PHD: 
102321416(MMP14)
CHX: 
100861171(MT1MMP)
OAS: 
443116(MMP14)
SSC: 
397471(MMP14)
CFR: 
BACU: 
103003307(MMP14)
LVE: 
103081188(MMP14)
ECB: 
100034170(MMP14)
MYB: 
102240202(MMP14)
MYD: 
102761559(MMP14)
PALE: 
102887003(MMP14)
MDO: 
100030382(MMP14)
SHR: 
100932143(MMP14)
OAA: 
100091029(MMP14)
PHI: 
ASN: 
102368749(MMP14)
AMJ: 
CMY: 
ACS: 
100553534(mmp14)
PBI: 
XLA: 
407753(mmp14)
XTR: 
594950(mmp14)
DRE: 
373882(mmp14a) 566945(mmp14b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102355301(MMP14)
BFO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409868(GB19151)
NVI: 
100113893(Mmp1)
TCA: 
BMOR: 
100144547(Mmp1)
API: 
PHU: 
ISC: 
TSP: 
HRO: 
LGI: 
NVE: 
PPER: 
 » show all
Taxonomy
Reference
1  [PMID:11532942]
  Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
  Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
  Journal
EMBO. J. 20 (2001) 4782-93.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
161384-17-4

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