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Entry
EC 3.4.24.81                Enzyme                                 

Name
ADAM10 endopeptidase;
Kuzbanian protein;
myelin-associated disintegrin metalloproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase of broad specificity
Comment
In peptidase family M12. Partially responsible for the "alpha-secretase" activity in brain that degrades the potentially harmful beta-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.
History
EC 3.4.24.81 created 2003
Orthology
K06704  
disintegrin and metalloproteinase domain-containing protein 10
Genes
HSA: 
102(ADAM10)
PTR: 
746942(ADAM10)
PPS: 
100979438(ADAM10)
GGO: 
101142970(ADAM10)
PON: 
100169741(ADAM10)
MCC: 
701355(ADAM10)
MCF: 
MMU: 
11487(Adam10)
RNO: 
29650(Adam10)
CGE: 
100772891(Adam10)
HGL: 
101698280(Adam10)
TUP: 
102467957(ADAM10)
CFA: 
478321(ADAM10)
AML: 
100476350(ADAM10)
FCA: 
101087998(ADAM10)
PTG: 
102950285(ADAM10)
BTA: 
282132(ADAM10)
BOM: 
102285401(ADAM10)
PHD: 
102324691(ADAM10)
CHX: 
102172903(ADAM10)
SSC: 
397345(ADAM10)
CFR: 
102518129(ADAM10)
BACU: 
103011557(ADAM10)
LVE: 
103071850(ADAM10)
ECB: 
100068314(ADAM10)
MYB: 
102260183(ADAM10)
MYD: 
102754258(ADAM10)
PALE: 
102895434(ADAM10)
MDO: 
100027329(ADAM10)
SHR: 
OAA: 
100074755(ADAM10)
GGA: 
374113(ADAM10)
TGU: 
100219653(ADAM10)
FAB: 
101811782(ADAM10)
PHI: 
102110765(ADAM10)
APLA: 
101794215(ADAM10)
FPG: 
101910860(ADAM10)
FCH: 
102050786(ADAM10)
CLV: 
102083444(ADAM10)
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
399187(adam10)
XTR: 
733451(adam10)
DRE: 
393392(adam10b) 560975(ADAMLc) 566044(adam10a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_DY3.7(sup-17)
CBR: 
CBG12369(Cbr-sup-17)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
MBR: 
 » show all
Taxonomy
Reference
1  [PMID:12475894]
  Authors
Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Gast D, Joumaa S, Zentgraf H, Fogel M, Altevogt DP.
  Title
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
  Journal
FASEB. J. 17 (2003) 292-4.
  Organism
Homo sapiens
  Sequence
[hsa:102]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
193099-09-1

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