KEGG   ENZYME: 3.4.24.86Help
Entry
EC 3.4.24.86                Enzyme                                 
Name
ADAM 17 endopeptidase;
tumor necrosis factor alpha-converting enzyme;
TACE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Comment
In peptidase family M12. In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.
Orthology
K06059  
disintegrin and metalloproteinase domain-containing protein 17
Genes
HSA: 
6868(ADAM17)
PTR: 
459018(ADAM17)
PPS: 
100988650(ADAM17)
GGO: 
PON: 
100439426(ADAM17)
MCC: 
694429(ADAM17)
MMU: 
11491(Adam17)
RNO: 
57027(Adam17)
CFA: 
475662(ADAM17)
AML: 
100482770(ADAM17)
FCA: 
101089004(ADAM17)
BTA: 
517541(ADAM17)
SSC: 
397343(ADAM17)
ECB: 
100072496(ADAM17)
MDO: 
100032069
SHR: 
100926795(ADAM17)
OAA: 
100086345(ADAM17)
GGA: 
421931(ADAM17)
MGP: 
100549409(ADAM17)
TGU: 
100225922(ADAM17)
ACS: 
100563907(adam17)
XLA: 
733430(adam17)
XTR: 
100492947(adam17)
DRE: 
324142(adam17a) 560657(adam17b)
TRU: 
101063716 101075639
OLA: 
101165277 101171872
BFO: 
BRAFLDRAFT_213750
CIN: 
100175230
SPU: 
585715
DME: 
Dmel_CG7908(Tace)
DPO: 
Dpse_GA26934
DAN: 
Dana_GF18815
DER: 
Dere_GG11719
DPE: 
Dper_GL14016
DSE: 
Dsec_GM12850
DSI: 
Dsim_GD21492
DWI: 
Dwil_GK13920
DYA: 
Dyak_GE10847
DGR: 
Dgri_GH18563
DMO: 
Dmoj_GI10801
DVI: 
Dvir_GJ14399
AGA: 
AgaP_AGAP002381
AAG: 
AaeL_AAEL003910
CQU: 
CpipJ_CPIJ005931
AME: 
551599
NVI: 
100119121(NV14306)
TCA: 
663540
API: 
100158671
PHU: 
Phum_PHUM024730
ISC: 
IscW_ISCW001461
CEL: 
CELE_ZK154.7(adm-4)
CBR: 
CBG16796(Cbr-adm-4)
TSP: 
Tsp_02601
SMM: 
Smp_175340.1
HMG: 
100210793
TAD: 
TRIADDRAFT_58971
MBR: 
MONBRDRAFT_22277
 » show all
Taxonomy
Reference
1  [PMID:11733179]
  Authors
Black RA.
  Title
Tumor necrosis factor-alpha converting enzyme.
  Journal
Int. J. Biochem. Cell. Biol. 34 (2002) 1-5.
  Organism
Mus musculus [GN:mmu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
151769-16-3
DBGET integrated database retrieval system