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Entry
EC 3.4.24.86                Enzyme                                 

Name
ADAM 17 endopeptidase;
tumor necrosis factor alpha-converting enzyme;
TACE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Comment
In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.
History
EC 3.4.24.86 created 2003
Orthology
K06059  
disintegrin and metalloproteinase domain-containing protein 17
Genes
HSA: 
6868(ADAM17)
PTR: 
459018(ADAM17)
PPS: 
100988650(ADAM17)
GGO: 
PON: 
100439426(ADAM17)
MCC: 
694429(ADAM17)
MCF: 
102116784(ADAM17)
MMU: 
11491(Adam17)
RNO: 
57027(Adam17)
CGE: 
100684971(Adam17)
HGL: 
101720924(Adam17)
TUP: 
102496316(ADAM17)
CFA: 
475662(ADAM17)
AML: 
100482770(ADAM17)
FCA: 
101089004(ADAM17)
BTA: 
517541(ADAM17)
BOM: 
102279111(ADAM17)
PHD: 
102319953(ADAM17)
CHX: 
102188327(ADAM17)
SSC: 
397343(ADAM17)
CFR: 
102508816(ADAM17)
ECB: 
100072496(ADAM17)
MYB: 
102256292(ADAM17)
MDO: 
SHR: 
100926795(ADAM17)
OAA: 
100086345(ADAM17)
GGA: 
421931(ADAM17)
MGP: 
100549409(ADAM17)
TGU: 
100225922(ADAM17)
FAB: 
101814343(ADAM17)
PHI: 
102106429(ADAM17)
APLA: 
101794295(ADAM17)
FPG: 
101924106(ADAM17)
FCH: 
102055911(ADAM17)
CLV: 
102098173(ADAM17)
ASN: 
102373202(ADAM17)
PSS: 
102454376(ADAM17)
ACS: 
100563907(adam17)
XLA: 
733430(adam17)
XTR: 
100492947(adam17)
DRE: 
324142(adam17a) 560657(adam17b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102367618(ADAM17)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551599(GB18818)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG16796(Cbr-adm-4)
LOA: 
TSP: 
SMM: 
HMG: 
TAD: 
MBR: 
 » show all
Taxonomy
Reference
1  [PMID:11733179]
  Authors
Black RA.
  Title
Tumor necrosis factor-alpha converting enzyme.
  Journal
Int. J. Biochem. Cell. Biol. 34 (2002) 1-5.
  Organism
Mus musculus [GN:mmu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
151769-16-3

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