KEGG   ENZYME: 3.4.24.87Help
Entry
EC 3.4.24.87                Enzyme                                 

Name
ADAMTS13 endopeptidase;
ADAMTS VWF cleaving metalloprotease;
ADAMTS-13;
ADAMTS13;
vWF-cleaving protease;
VWF-CP;
vWF-degrading protease;
Upshaw factor;
von Willebrand factor cleaving protease;
ADAMTS13 peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme cleaves the von Willebrand factor at bond Tyr842!Met843 within the A2 domain
Comment
In peptidase family M12.
History
EC 3.4.24.87 created 2009
Orthology
K08627  
a disintegrin and metalloproteinase with thrombospondin motifs 13
Genes
HSA: 
11093(ADAMTS13)
PTR: 
473153(ADAMTS13)
PPS: 
GGO: 
101151958(ADAMTS13)
PON: 
100459418(ADAMTS13)
MCF: 
102145096(ADAMTS13)
MMU: 
279028(Adamts13)
CGE: 
100770010(Adamts13)
HGL: 
101713585(Adamts13)
TUP: 
102474078(ADAMTS13)
CFA: 
100630922(ADAMTS13)
AML: 
100481099(ADAMTS13)
FCA: 
101086761(ADAMTS13)
PTG: 
102959927(ADAMTS13)
BTA: 
532272(ADAMTS13)
BOM: 
102287814(ADAMTS13)
PHD: 
102329634(ADAMTS13)
CHX: 
102174580(ADAMTS13)
OAS: 
101112214(ADAMTS13)
SSC: 
100627950(ADAMTS13)
CFR: 
102506864(ADAMTS13)
BACU: 
102999611(ADAMTS13)
LVE: 
103074204(ADAMTS13)
ECB: 
100069281(ADAMTS13)
MYB: 
102240335(ADAMTS13)
MYD: 
102764800(ADAMTS13)
PALE: 
102885523(ADAMTS13)
MDO: 
100018539(ADAMTS13)
SHR: 
100924870(ADAMTS13)
OAA: 
100077268(ADAMTS13)
GGA: 
417152(ADAMTS13)
MGP: 
TGU: 
100226372(ADAMTS13)
FAB: 
101809354(ADAMTS13)
PHI: 
102109550(ADAMTS13)
APLA: 
101800615(ADAMTS13)
FPG: 
101910275(ADAMTS13)
FCH: 
102055781(ADAMTS13)
CLV: 
102096762(ADAMTS13)
ASN: 
102379615(ADAMTS13)
AMJ: 
102565959(ADAMTS13)
PSS: 
102455064(ADAMTS13)
CMY: 
102937118(ADAMTS13)
PBI: 
103050431(ADAMTS13)
XTR: 
100485801(adamts13)
DRE: 
100320289(adamts13)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102349966(ADAMTS13)
CMK: 
103184703(adamts13)
 » show all
Taxonomy
Reference
1  [PMID:11535495]
  Authors
Fujikawa K, Suzuki H, McMullen B, Chung D
  Title
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.
  Journal
Blood. 98 (2001) 1662-6.
  Sequence
[hsa:11093]
Reference
2  [PMID:12393397]
  Authors
Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, Lopez JA
  Title
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.
  Journal
Blood. 100 (2002) 4033-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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