KEGG   ENZYME: 3.4.24.87Help
Entry
EC 3.4.24.87                Enzyme                                 

Name
ADAMTS13 endopeptidase;
ADAMTS VWF cleaving metalloprotease;
ADAMTS-13;
ADAMTS13;
vWF-cleaving protease;
VWF-CP;
vWF-degrading protease;
Upshaw factor;
von Willebrand factor cleaving protease;
ADAMTS13 peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme cleaves the von Willebrand factor at bond Tyr842!Met843 within the A2 domain
Comment
In peptidase family M12.
History
EC 3.4.24.87 created 2009
Reference
1  [PMID:11535495]
  Authors
Fujikawa K, Suzuki H, McMullen B, Chung D
  Title
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.
  Journal
Blood. 98 (2001) 1662-6.
  Organism
Homo sapiens
  Sequence
[hsa:11093]
Reference
2  [PMID:12393397]
  Authors
Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, Lopez JA
  Title
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.
  Journal
Blood. 100 (2002) 4033-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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