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Entry
EC 3.5.1.101                Enzyme                                 

Name
L-proline amide hydrolase;
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase;
LaaA;
L-amino acid amidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
(S)-piperidine-2-carboxamide amidohydrolase
Reaction(IUBMB)
(1) (S)-piperidine-2-carboxamide + H2O = (S)-piperidine-2-carboxylic acid + NH3 [RN:R09680];
(2) L-prolinamide + H2O = L-proline + NH3 [RN:R09650]
Reaction(KEGG)
R09650 R09680;
(other) R09649
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Substrate
(S)-piperidine-2-carboxamide [CPD:C19809];
H2O [CPD:C00001];
L-prolinamide [CPD:C19781]
Product
(S)-piperidine-2-carboxylic acid [CPD:C00408];
NH3 [CPD:C00014];
L-proline [CPD:C00148]
History
EC 3.5.1.101 created 2009
Orthology
K18457  
L-proline amide hydrolase
Genes
PHD: 
ELA: 
ZTR: 
PFJ: 
BCOM: 
SHS: 
ADL: 
FME: 
CPUT: 
GTT: 
ENR: 
KOX: 
KOE: 
KOY: 
SERR: 
DDC: 
DDD: 
RAH: 
RAQ: 
RAA: 
XCC: 
XCB: 
XCA: 
XCP: 
XCV: 
XCV3134(pip)
XAC: 
XCI: 
XAX: 
XAO: 
XOO: 
XOM: 
XOP: 
XOR: 
XFU: 
PST: 
PSB: 
PSP: 
PFL: 
PPRC: 
PFS: 
PFE: 
PFC: 
PPZ: 
PBA: 
PSK: 
PCH: 
AAA: 
MLO: 
MCI: 
MOP: 
MAM: 
SME: 
SMc04031(pip2)
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
ARA: 
Arad_8444(pipb1)
AVI: 
RET: 
REC: 
REL: 
RLE: 
pRL90179(pepI)
RLT: 
RLG: 
RLB: 
RLU: 
RTR: 
RHL: 
RCP: 
SSY: 
AMV: 
GXL: 
RRU: 
RRF: 
VIR: 
MSM: 
MSG: 
MSA: 
CVA: 
CVAR_1950(pepI)
SSX: 
SFA: 
SHY: 
SHO: 
STRP: 
MTS: 
SRO: 
KRA: 
AMI: 
KAL: 
STP: 
ASE: 
ACPL_6077(pip2)
 » show all
Taxonomy
Reference
1  [PMID:15066172]
  Authors
Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y
  Title
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase.
  Journal
Eur. J. Biochem. 271 (2004) 1465-75.
  Sequence
[up:Q76KX0]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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