KEGG   ENZYME: 3.5.1.102Help
Entry
EC 3.5.1.102                Enzyme                                 

Name
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
ArfB
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase
Reaction(IUBMB)
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate [RN:R09374]
Reaction(KEGG)
Substrate
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
H2O [CPD:C00001]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304];
formate [CPD:C00058]
Comment
The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis. The first step is catalysed by EC 3.5.4.29 (GTP cyclohydrolase IIa). The bacterial enzyme, EC 3.5.4.25 (GTP cyclohydrolase II) catalyses both reactions.
History
EC 3.5.1.102 created 2010, modified 2011
Pathway
Riboflavin metabolism
Metabolic pathways
Orthology
K14653  
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MTH: 
MMG: 
MST: 
MSI: 
MRU: 
mru_1283(arfB)
MEB: 
Abm4_0796(arfB)
MEL: 
MEW: 
METH: 
MFV: 
 » show all
Taxonomy
Reference
1  [PMID:19309161]
  Authors
Grochowski LL, Xu H, White RH
  Title
An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin.
  Journal
Biochemistry. 48 (2009) 4181-8.
  Organism
Methanocaldococcus jannaschii
  Sequence
[mja:MJ_0116]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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