KEGG   ENZYME: 3.5.1.11Help
Entry
EC 3.5.1.11                 Enzyme                                 
Name penicillin amidase;
penicillin acylase;
benzylpenicillin acylase;
novozym 217;
semacylase;
alpha-acylamino-beta-lactam acylhydrolase;
ampicillin acylase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname penicillin amidohydrolase
Reaction(IUBMB) penicillin + H2O = a carboxylate + 6-aminopenicillanate [RN:R02170]
Reaction(KEGG) R02170 > R04103
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Substrate penicillin [CPD:C00395];
H2O [CPD:C00001]
Product carboxylate [CPD:C00060];
6-aminopenicillanate [CPD:C02954]
Pathway PATH: ec00311  Penicillin and cephalosporin biosynthesis
Orthology KO: K01434  penicillin amidase
Genes TET: TTHERM_00898180
ECR: ECIAI1_4561
SBO: SBO_4393
SBC: SbBS512_E4877
SPE: Spro_3142
DDA: Dd703_3059
XCC: XCC1392(acyII)
XCB: XC_2845
XCV: XCV0041 XCV0042 XCV1494
XAC: XAC0037 XAC1437(acyII)
XOO: XOO1993(acyII)
XOM: XOO_1884
SML: Smlt1522
PAU: PA14_03980
PPF: Pput_1147
PMY: Pmen_1414
ACB: A1S_1851
ABY: ABAYE1713
ABN: AB57_2186
ABB: ABBFA_001601
SDN: Sden_3735
SAZ: Sama_3540
SLO: Shew_2669
SSE: Ssed_3220
CPS: CPS_1223
CBD: CBUD_0858
MCA: MCA3025(acyII)
RPI: Rpic_4199
RPF: Rpic12D_4309
REU: Reut_A1841
REH: H16_A1918 H16_B2499
RME: Rmet_1578 Rmet_5635
CTI: RALTA_A1608
BMA: BMA1038 BMAA1877
BMV: BMASAVP1_0887 BMASAVP1_A1484
BML: BMA10229_1174 BMA10229_A0153
BMN: BMA10247_1011 BMA10247_A2152
BPS: BPSL0730 BPSL1710 BPSS0200
BPM: BURPS1710b_0953(acyII) BURPS1710b_2163(acyII) BURPS1710b_A1726
BPL: BURPS1106A_0792 BURPS1106A_2028 BURPS1106A_A0278
BPD: BURPS668_0780 BURPS668_2008 BURPS668_2114 BURPS668_A0371
BTE: BTH_I0631
BUR: Bcep18194_B0916
PNU: Pnuc_1150
RFR: Rfer_1547
POL: Bpro_2452
VEI: Veis_1397 Veis_3277 Veis_4305
MPT: Mpe_A1822
NEU: NE1123
NET: Neut_1415
NMU: Nmul_A0961
BBA: Bd2313
ADE: Adeh_3892
RFE: RF_1137
BMB: BruAb2_1029
SIL: SPO2078
SIT: TM1040_1354
RSP: RSP_2845
RSH: Rsph17029_1448
RSQ: Rsph17025_1495
JAN: Jann_2327
RDE: RD1_2752(acy)
PDE: Pden_4002 Pden_4813
DSH: Dshi_1565
MMR: Mmar10_1553
HNE: HNE_0221
SAL: Sala_2388
SWI: Swit_0920
GBE: GbCGDNIH1_0997
RRU: Rru_A1840
MAG: amb2576
BAN: BA3330
BAR: GBAA3330
BAA: BA_3832
BAT: BAS3087
BCE: BC3254
BCA: BCE_3292
BCZ: BCZK2980
BTK: BT9727_3031
BTL: BALH_2953
OIH: OB3304 OB3305
SAJ: SaurJH9_0259
SAH: SaurJH1_0266
LLA: L86424(pacB)
STH: STH69
SCO: SCO3184(SCE22.01c)
AAU: AAur_3669
KRH: KRH_10940
NCA: Noca_0788
TFU: Tfu_1644
STP: Strop_2556 Strop_4404
RXY: Rxyl_2001
LIL: LA0330
ABA: Acid345_3370
SUS: Acid_0605 Acid_4936 Acid_5979
RBA: RB2202
SYN: slr1772
SYF: Synpcc7942_2150
GVI: glr1988
AVA: Ava_1773
RCA: Rcas_1469
CAU: Caur_3748
CAG: Cagg_0786
CHL: Chy400_4048
HAU: Haur_4995
DGE: Dgeo_0269
TTH: TTC1972
TTJ: TTHA0024
HMA: rrnB0229(pga-1) rrnB0230(pga-2)
PCL: Pcal_1846
Taxonomy
Structures PDB: 1AI4  1AI5  1AI6  1AI7  1AJN  1AJP  1AJQ  1CP9  1E3A  1FXH  
     1FXV  1GK0  1GK1  1GK9  1GKF  1GM7  1GM8  1GM9  1H2G  1JX9  
     1K5Q  1K5S  1K7D  1KEC  1PNK  1PNL  1PNM  2ADV  2AE3  2AE4  
     2AE5  2IWM  2OQC  2PVA  2QUY  2Z71  3K3W  3PVA  
Reference
  Authors
  Title
  Journal
 1
Sakaguchi, K. and Murao, S.
A preliminary report on a new enzyme, "penicillin-amidase".
J. Agric. Chem. Soc. Jpn. 23 (1950) 411.
Other DBs ExplorEnz - The Enzyme Database: 3.5.1.11
IUBMB Enzyme Nomenclature: 3.5.1.11
ExPASy - ENZYME nomenclature database: 3.5.1.11
BRENDA, the Enzyme Database: 3.5.1.11
CAS: 9014-06-6
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