KEGG   ENZYME: 3.5.1.14Help
Entry
EC 3.5.1.14                 Enzyme                                 
Name aminoacylase;
dehydropeptidase II;
histozyme;
hippuricase;
benzamidase;
acylase I;
hippurase;
amido acid deacylase;
L-aminoacylase;
acylase;
aminoacylase I;
L-amino-acid acylase;
alpha-N-acylaminoacid hydrolase;
long acyl amidoacylase;
short acyl amidoacylase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname N-acyl-L-amino-acid amidohydrolase
Reaction(IUBMB) an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid
[RN:R01263]
Reaction(KEGG) R01263 > R00669
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Substrate N-acyl-L-amino acid [CPD:C02850];
H2O [CPD:C00001]
Product carboxylate [CPD:C00060];
L-amino acid [CPD:C00151]
Comment Wide specificity; also hydrolyses dehydropeptides. Used in
separating D- and L- amino acids
Pathway PATH: ec00330  Arginine and proline metabolism
PATH: ec01064  Biosynthesis of alkaloids derived from ornithine,
               lysine and nicotinic acid
PATH: ec01100  Metabolic pathways
Orthology KO: K01436  aminoacylase
Genes HSA: 95(ACY1)
PTR: 460414(ACY1)
MCC: 698851(ABHD14A)
MMU: 109652(Acy1)
RNO: 300981(Acy1)
CFA: 476602(ACY1)
BTA: 790609
SSC: 396930(ACY1)
ECB: 100060631
MDO: 100031141
OAA: 100075293
TGU: 100219242
XLA: 446741(acy1)
XTR: 496883(acy1)
DRE: 393970
SPU: 577570
DME: Dmel_CG17109 Dmel_CG17110 Dmel_CG6465 Dmel_CG6726 Dmel_CG6733
     Dmel_CG6738
DPO: Dpse_GA19815 Dpse_GA19818
AGA: AgaP_AGAP000679
AAG: AaeL_AAEL011206
CQU: CpipJ_CPIJ009804
AME: 408969
TCA: 657672
CEL: C06A6.4(aminoacylase-1) C10C5.3(aminoacylase-1)
     C10C5.4(aminoacylase-1) C10C5.5(aminoacylase-1)
CBR: CBG17687
ATH: AT1G44180 AT1G44820
OSA: 4340457(Os06g0210200)
CME: CMA011C
DDI: DDBDRAFT_0201767
TET: TTHERM_00475260
TBR: Tb927.1.3000
TCR: 506363.70 506363.80 506363.90 506975.30 506975.40
LMA: LmjF20.1550 LmjF20.1560 LmjF20.1570 LmjF30.1380 LmjF31.1130
HSO: HS_1434(amaA)
XCC: XCC3786(amaA)
XCB: XC_3858
XCA: xccb100_3969
XCV: XCV3964
XAC: XAC3847(amaA)
XOO: XOO4187(amaA)
XOM: XOO_3956
XOP: PXO_03984
SML: Smlt4278
SMT: Smal_3688
PCR: Pcryo_1258
SFR: Sfri_0302
SBL: Sbal_0206
SBM: Shew185_4131
SBN: Sbal195_4257
SBP: Sbal223_0208
SHE: Shewmr4_3743
SHM: Shewmr7_3816
SHN: Shewana3_3941
SWD: Swoo_0259
PHA: PSHAa2416
FTU: FTT_1191
FTF: FTF1191
REU: Reut_A1358
REH: H16_B0491 H16_B1209
NIS: NIS_1768
SUN: SUN_0171
PPD: Ppro_2428
DVU: DVU2568
DVL: Dvul_0678
DVM: DvMF_1012
DDE: Dde_2667
SFU: Sfum_1222
BME: BMEI0033 BMEI1827
RPE: RPE_1861
SWI: Swit_4303
GOX: GOX2239
BAN: BA1392(amaA)
BAR: GBAA1392(amaA)
BAA: BA_1294 BA_1916
BAT: BAS0672 BAS1289
BAH: BAMEG_3202(amaA) BAMEG_3881
BCE: BC0701 BC1374 BC3664
BCA: BCE_0775 BCE_1490(amaA) BCE_3698(hipO)
BCZ: BCZK0616(amaA) BCZK1263(amaA) BCZK2908(amaA) BCZK3370(amaA)
BCR: BCAH187_A0834 BCAH187_A1532(amaA) BCAH187_A3705
BCB: BCB4264_A0740 BCB4264_A1426(amaA) BCB4264_A3771
BCU: BCAH820_0760 BCAH820_1463(amaA) BCAH820_3681
BCG: BCG9842_B1544 BCG9842_B3918(amaA) BCG9842_B4597
BCQ: BCQ_0775(amaA) BCQ_1448(amaA) BCQ_3467(hipO)
BCX: BCA_0743 BCA_1428(amaA) BCA_3763
BCY: Bcer98_0594 Bcer98_1094
BTK: BT9727_0616(amaA) BT9727_1261(amaA) BT9727_2973(amaA)
     BT9727_2974 BT9727_3419
BTL: BALH_0641(cpsA) BALH_1232 BALH_3303
BWE: BcerKBAB4_0621 BcerKBAB4_1296
BLI: BL03949
BLD: BLi04023
BCL: ABC0022 ABC1615 ABC1855 ABC2804
GKA: GK3242 GK3251
GTN: GTNG_2286 GTNG_3185
GWC: GWCH70_3175
SAB: SAB0042 SAB2206c
SAA: SAUSA300_0105 SAUSA300_2276
SAJ: SaurJH9_0572
SAH: SaurJH1_0093 SaurJH1_0586
ESI: Exig_0469
LLM: llmg_0664(amd) llmg_1571(hipO2)
STC: str0554(hipO1)
STL: stu0554(hipO1)
STE: STER_0594
SSA: SSA_0587(hipO1)
LPL: lp_3044(amd)
LDB: Ldb0265
LCA: LSEI_2899
LME: LEUM_0113
CTH: Cthe_2073
CDF: CD2173
CKL: CKL_0651(amaA)
CKR: CKR_0577
AMT: Amet_1192
DSY: DSY3055
DHD: Dhaf_4224
MTA: Moth_1962
MPA: MAP3426c(amiA)
MAV: MAV_4281
MSM: MSMEG_1703
MUL: MUL_2671(amiA1)
MVA: Mvan_1612
MGI: Mflv_4826
MAB: MAB_3658c
MMC: Mmcs_1246
MKM: Mkms_1263
MJL: Mjls_1273
MMI: MMAR_1221(amiA1)
RHA: RHA1_ro06260
ROP: ROP_63210
ART: Arth_1133
AAU: AAur_1249
ACH: Achl_1206
RSA: RSal33209_0306
NCA: Noca_3542
FRA: Francci3_0694
SEN: SACE_6534
STP: Strop_0833
BAD: BAD_0995
LIL: LA2674
LIC: LIC11318(amaA)
CHU: CHU_0130(ammA)
FNU: FN0590 FN0702 FN0703 FN1063
SYN: slr1653(ama)
SYC: syc1257_c(ama)
SYF: Synpcc7942_0256 Synpcc7942_1971
SYP: SYNPCC7002_A2402(ama) SYNPCC7002_A2759
TEL: tll2447
MAR: MAE_24420
CYT: cce_1897(ama2)
CYP: PCC8801_4368
CYC: PCC7424_3557
GVI: glr0374
ANA: alr4934
NPU: Npun_R2370
AVA: Ava_1059 Ava_2218
PMN: PMN2A_1190
PMI: PMT9312_1706
PME: NATL1_20651
TER: Tery_1843 Tery_3690
CPH: Cpha266_1330
DRA: DR_1711
DGE: Dgeo_0208
TTH: TTC0133
PTO: PTO0772 PTO1086
Taxonomy
Structures PDB: 1Q7L  1YSJ  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:14927637]
BIRNBAUM SM, LEVINTOW L, KINGSLEY RB, GREENSTEIN JP.
Specificity of amino acid acylases.
J. Biol. Chem. 194 (1952) 455-70.
Sus scofa [GN:ssc]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:13061423]
FONES WS, LEE M.
Hydrolysis of N-acyl derivatives of alanine and phenylalanine by
acylase I and carboxypeptidase.
J. Biol. Chem. 201 (1953) 847-56.
Sus scofa [GN:ssc]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:13732833]
PARK RW, FOX SW.
An acylase system related to the utilization of benzoylamino acids
by Lactobacillus arabinosus.
J. Biol. Chem. 235 (1960) 3193-7.
Lactobacillus arabinosus
Other DBs ExplorEnz - The Enzyme Database: 3.5.1.14
IUBMB Enzyme Nomenclature: 3.5.1.14
ExPASy - ENZYME nomenclature database: 3.5.1.14
BRENDA, the Enzyme Database: 3.5.1.14
CAS: 9012-37-7
DBGET integrated database retrieval system