KEGG   ENZYME: 3.5.1.14Help
Entry
EC 3.5.1.14                 Enzyme                                 

Name
aminoacylase;
dehydropeptidase II;
histozyme;
hippuricase;
benzamidase;
acylase I;
hippurase;
amido acid deacylase;
L-aminoacylase;
acylase;
aminoacylase I;
L-amino-acid acylase;
alpha-N-acylaminoacid hydrolase;
long acyl amidoacylase;
short acyl amidoacylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-acyl-L-amino-acid amidohydrolase
Reaction(IUBMB)
an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid [RN:R01263]
Reaction(KEGG)
Substrate
N-acyl-L-amino acid [CPD:C02850];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
L-amino acid [CPD:C00151]
Comment
Wide specificity; also hydrolyses dehydropeptides. Used in separating D- and L- amino acids
Pathway
Arginine and proline metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K14677  
aminoacylase
Genes
HSA: 
95(ACY1)
PTR: 
460414(ACY1)
PPS: 
100989711(ACY1)
GGO: 
PON: 
100171519(ACY1)
MCC: 
698851(ABHD14A)
MMU: 
109652(Acy1)
RNO: 
300981(Acy1)
CFA: 
476602(ACY1)
AML: 
FCA: 
BTA: 
768058(ACY1)
SSC: 
396930(ACY1)
ECB: 
100060631(ACY1)
MDO: 
SHR: 
OAA: 
GGA: 
MGP: 
TGU: 
100219242(ACY1)
ACS: 
XLA: 
446741(acy1.1)
XTR: 
496883(acy1.1)
DRE: 
393970(acy1)
TRU: 
OLA: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
100114283(NV16582)
TCA: 
API: 
PHU: 
CEL: 
CELE_C10C5.5(C10C5.5)
CBR: 
TSP: 
SMM: 
TAD: 
AQU: 
ATH: 
ALY: 
GMX: 
MTR: 
CSV: 
RCU: 
POP: 
VVI: 
OSA: 
DOSA: 
Os08t0511900-01(Os08g0511900)
BDI: 
SBI: 
SORBI_07g027550(SORBIDRAFT_07g027550)
ZMA: 
SMO: 
PPP: 
CME: 
MBR: 
NGR: 
DDI: 
DPP: 
PTI: 
TPS: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:14927637]
  Authors
BIRNBAUM SM, LEVINTOW L, KINGSLEY RB, GREENSTEIN JP.
  Title
Specificity of amino acid acylases.
  Journal
J. Biol. Chem. 194 (1952) 455-70.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:13061423]
  Authors
FONES WS, LEE M.
  Title
Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase.
  Journal
J. Biol. Chem. 201 (1953) 847-56.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:13732833]
  Authors
PARK RW, FOX SW.
  Title
An acylase system related to the utilization of benzoylamino acids by Lactobacillus arabinosus.
  Journal
J. Biol. Chem. 235 (1960) 3193-7.
  Organism
Lactobacillus arabinosus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-37-7

DBGET integrated database retrieval system