KEGG   ENZYME: 3.5.1.14Help
Entry
EC 3.5.1.14                 Enzyme                                 
Name
aminoacylase;
dehydropeptidase II;
histozyme;
hippuricase;
benzamidase;
acylase I;
hippurase;
amido acid deacylase;
L-aminoacylase;
acylase;
aminoacylase I;
L-amino-acid acylase;
alpha-N-acylaminoacid hydrolase;
long acyl amidoacylase;
short acyl amidoacylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-acyl-L-amino-acid amidohydrolase
Reaction(IUBMB)
an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid [RN:R01263]
Reaction(KEGG)
Substrate
N-acyl-L-amino acid [CPD:C02850];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
L-amino acid [CPD:C00151]
Comment
Wide specificity; also hydrolyses dehydropeptides. Used in separating D- and L- amino acids
Pathway
Arginine and proline metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K14677  
aminoacylase
Genes
HSA: 
95(ACY1)
PTR: 
460414(ACY1)
PPS: 
100989711(ACY1)
GGO: 
PON: 
100171519(ACY1)
MCC: 
698851(ABHD14A)
MMU: 
109652(Acy1)
RNO: 
300981(Acy1)
CFA: 
476602(ACY1)
AML: 
FCA: 
101101118
BTA: 
768058(ACY1)
SSC: 
396930(ACY1)
ECB: 
100060631(ACY1)
MDO: 
100031141
SHR: 
100934680
OAA: 
100075293
GGA: 
100858836
MGP: 
100550404
TGU: 
100219242(ACY1)
ACS: 
100567123
XLA: 
446741(acy1.1)
XTR: 
496883(acy1.1)
DRE: 
393970(acy1)
TRU: 
101072726
OLA: 
101160548
BFO: 
BRAFLDRAFT_262219
CIN: 
100185588
SPU: 
578000
DME: 
Dmel_CG6465 Dmel_CG6726
DPO: 
Dpse_GA19815 Dpse_GA26984 Dpse_GA27068 Dpse_GA29129 Dpse_GA29130
DAN: 
Dana_GF16975 Dana_GF17518 Dana_GF17519
DER: 
Dere_GG11184 Dere_GG17281 Dere_GG17282
DPE: 
Dper_GL13662 Dper_GL13663 Dper_GL23825 Dper_GL23826
DSE: 
Dsec_GM26165 Dsec_GM26166 Dsec_GM26483
DSI: 
Dsim_GD20716 Dsim_GD20717 Dsim_GD20996
DWI: 
Dwil_GK14410 Dwil_GK22579 Dwil_GK22580
DYA: 
Dyak_GE10351 Dyak_GE24682 Dyak_GE24683
DGR: 
Dgri_GH11206 Dgri_GH23739 Dgri_GH23814 Dgri_GH23872
DMO: 
Dmoj_GI18128 Dmoj_GI23017 Dmoj_GI23020
DVI: 
Dvir_GJ17753 Dvir_GJ24611 Dvir_GJ24614
AGA: 
AgaP_AGAP000679
AAG: 
AaeL_AAEL011206
CQU: 
CpipJ_CPIJ009804
AME: 
408969
NVI: 
100114283(NV16582)
TCA: 
657672
API: 
100162258 100169089
PHU: 
Phum_PHUM047660
CEL: 
CELE_C10C5.5(C10C5.5)
CBR: 
CBG17687
TSP: 
Tsp_07914
SMM: 
Smp_019630
TAD: 
TRIADDRAFT_50344
AQU: 
100634447
ATH: 
AT1G44820 AT4G38220
ALY: 
ARALYDRAFT_327784 ARALYDRAFT_473822
GMX: 
100783172
MTR: 
MTR_1g038920 MTR_1g039010
CSV: 
101213747
RCU: 
RCOM_1565970
POP: 
POPTR_721246
VVI: 
100260562
OSA: 
4340457
DOSA: 
Os08t0511900-01(Os08g0511900)
BDI: 
100839108
SBI: 
SORBI_07g027550(SORBIDRAFT_07g027550)
ZMA: 
100282205
SMO: 
SELMODRAFT_120255 SELMODRAFT_406809
PPP: 
PHYPADRAFT_207940
CME: 
CMA011C
MBR: 
MONBRDRAFT_32786
NGR: 
NAEGRDRAFT_77264 NAEGRDRAFT_81120
DDI: 
DDB_G0270562(acy1)
DPP: 
DICPUDRAFT_53427
PTI: 
PHATRDRAFT_15083
TPS: 
THAPSDRAFT_15114
PIF: 
PITG_00028 PITG_00029 PITG_02852
 » show all
Taxonomy
Reference
1  [PMID:14927637]
  Authors
BIRNBAUM SM, LEVINTOW L, KINGSLEY RB, GREENSTEIN JP.
  Title
Specificity of amino acid acylases.
  Journal
J. Biol. Chem. 194 (1952) 455-70.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:13061423]
  Authors
FONES WS, LEE M.
  Title
Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase.
  Journal
J. Biol. Chem. 201 (1953) 847-56.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:13732833]
  Authors
PARK RW, FOX SW.
  Title
An acylase system related to the utilization of benzoylamino acids by Lactobacillus arabinosus.
  Journal
J. Biol. Chem. 235 (1960) 3193-7.
  Organism
Lactobacillus arabinosus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-37-7
DBGET integrated database retrieval system