KEGG   ENZYME: 3.5.1.2Help
Entry
EC 3.5.1.2                  Enzyme                                 
Name glutaminase;
glutaminase I;
L-glutaminase;
glutamine aminohydrolase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname L-glutamine amidohydrolase
Reaction(IUBMB) L-glutamine + H2O = L-glutamate + NH3 [RN:R00256]
Reaction(KEGG) R00256;
(other) R01579 R06134
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Substrate L-glutamine [CPD:C00064];
H2O [CPD:C00001]
Product L-glutamate [CPD:C00025];
NH3 [CPD:C00014]
Pathway PATH: ec00250  Alanine, aspartate and glutamate metabolism
PATH: ec00330  Arginine and proline metabolism
PATH: ec00471  D-Glutamine and D-glutamate metabolism
PATH: ec00910  Nitrogen metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01425  glutaminase
Genes HSA: 27165(GLS2) 2744(GLS)
PTR: 451998(GLS2) 470606(GLS)
MCC: 712962
MMU: 14660(Gls) 216456(Gls2)
RNO: 192268(Gls2) 24398(Gls)
CFA: 488448(GLS)
BTA: 525335(GLS) 539561(GLS2)
SSC: 100151833
ECB: 100059765 100069617
MDO: 100024307
OAA: 100088607
GGA: 424043(GLS)
TGU: 100231894
DRE: 564147(glsl) 564746(gls)
BFO: BRAFLDRAFT_57682
CIN: 100182760
SPU: 575775 758743
DME: Dmel_CG8772(nemy)
DPO: Dpse_GA21309
DAN: Dana_GF11462
DER: Dere_GG22560
DPE: Dper_GL17734
DSE: Dsec_GM20343
DSI: Dsim_GD25822
DYA: Dyak_GE13430
DGR: Dgri_GH19960
DMO: Dmoj_GI19918
AAG: AaeL_AAEL008559
CQU: CpipJ_CPIJ006569
AME: 408991
NVI: 100117430
TCA: 655577
ISC: IscW_ISCW020515
CEL: DH11.1(glutaminase) F30F8.2(glutaminase)
CBR: CBG13355
BMY: Bm1_16630
SMM: Smp_147040
TAD: TRIADDRAFT_32107
FGR: FG01801.1
AOR: AO090010000571
MBR: MONBRDRAFT_27154
TVA: TVAG_134820
ECO: b0485(ybaS) b1524(yneH)
ECJ: JW0474(ybaS) JW1517(yneH)
ECD: ECDH10B_0442(ybaS) ECDH10B_1655(yneH)
EBW: BWG_0366(ybaS) BWG_1343(yneH)
ECE: Z0606(ybaS) Z2179(yneH)
ECS: ECs0538 ECs2131
ECF: ECH74115_0578(glsA1) ECH74115_2137(glsA2)
ETW: ECSP_0552(ybaS) ECSP_2009(yneH)
ECG: E2348C_0420(ybaS) E2348C_1645(yneH)
ECC: c0605(ybaS) c1947(yneH)
ECI: UTI89_C0516(ybaS) UTI89_C1743(yneH)
ECP: ECP_0550 ECP_1508
ECV: APECO1_1527(ybaS) APECO1_644(yneH)
ECW: EcE24377A_0524(glsA1) EcE24377A_1724(glsA2)
ECX: EcHS_A0564(glsA1) EcHS_A1606(glsA2)
ECM: EcSMS35_0528(glsA1) EcSMS35_1648(glsA2)
ECY: ECSE_0510 ECSE_1614
ECL: EcolC_2134 EcolC_3131
ECK: EC55989_0498(ybaS) EC55989_1657(yneH)
ECQ: ECED1_0511(ybaS)
ECR: ECIAI1_0488(ybaS) ECIAI1_1536(yneH)
ECT: ECIAI39_1788(yneH)
ECZ: ECS88_0486(ybaS) ECS88_1601(yneH)
EUM: ECUMN_0524(ybaS) ECUMN_1792(yneH)
ELF: LF82_2553(ybaS) LF82_3564(yneH)
EBL: B21_00441(ybaS) B21_01492(yneH)
EBD: ECBD_2118 ECBD_3171
EBR: ECB_00436(ybaS) ECB_01481(yneH)
EOH: ECO103_0461(ybaS) ECO103_1654(yneH)
EOI: ECO111_0520(ybaS) ECO111_1920(yneH)
EOJ: ECO26_0520(ybaS) ECO26_2125(yneH)
EFE: EFER_1550(yneH) EFER_2818(ybaS)
STT: t1446
SPT: SPA1330(yneH)
SEK: SSPA1235
SPQ: SPAB_01779
SEC: SC1542(yneH)
SEH: SeHA_C1697
SEE: SNSL254_A1638
SEW: SeSA_A1630
SEA: SeAg_B1645
SED: SeD_A1810
SEG: SG1594(yneH)
SET: SEN1526(yneH)
SES: SARI_01462
STM: STM1525(yneH)
YPE: YPO0949 YPO1939
YPK: y2372 y3336
YPM: YP_1682(glsA1) YP_3492(glsA2)
YPA: YPA_0315 YPA_1322
YPN: YPN_3147
YPG: YpAngola_A0147 YpAngola_A2130
YPP: YPDSF_0565 YPDSF_1184
YPS: YPTB1937 YPTB3221
YPI: YpsIP31758_0822 YpsIP31758_2143
YPY: YPK_0823 YPK_2254
YPB: YPTS_1986 YPTS_3355
YEN: YE2500 YE3440 YE3691
SFL: SF0430(ybaS) SF1569(yneH)
SFX: S0437(ybaS) S1696(yneH)
SFV: SFV_0458(ybaS) SFV_1583(yneH)
SSN: SSON_0474(ybaS) SSON_1604(yneH)
SBO: SBO_0387(ybaS)
SBC: SbBS512_E0420(glsA) SbBS512_E1682(glsA)
SDY: SDY_1631(yneH)
ETA: ETA_16980(glsA)
PLU: plu1172
PAY: PAU_03288
ENT: Ent638_2007
ESA: ESA_01818
CTU: Ctu_21640(glsA)
KPN: KPN_01636(yneH)
KPE: KPK_2743
KPU: KP1_2676(yneH)
CKO: CKO_01543
SPE: Spro_4040
PMR: PMI0329(glsA)
EIC: NT01EI_0275 NT01EI_0904
ETR: ETAE_0268(yneH) ETAE_2866(ybaS)
VCH: VC0454
VCO: VC0395_A0006
VCM: VCM66_0439
VCJ: VCD_001153
VVU: VV1_1517
VVY: VV2882
VPA: VP2623
VHA: VIBHAR_03588
VSP: VS_2690
VEX: VEA_002449
VFI: VF_0423(yneH)
VFM: VFMJ11_0423
VSA: VSAL_I0536(glsA)
PPR: PBPRA3151
PAE: PA1638
PAU: PA14_43320(glsA)
PAP: PSPA7_3635
PAG: PLES_36891
PPF: Pput_3197
PST: PSPTO_2488
PSB: Psyr_2292
PSP: PSPPH_2883
PFL: PFL_3159(glsA)
PFO: Pfl01_3373
PFS: PFLU3587
PEN: PSEEN3312
PMY: Pmen_0139
PSA: PST_0190
PCR: Pcryo_1330
ACI: ACIAD1040
ACB: A1S_0962
ABY: ABAYE2832
ABC: ACICU_00923
ABN: AB57_1038
ABB: ABBFA_002649
SON: SO_3365(glsA)
SDN: Sden_2695
SFR: Sfri_2870
SAZ: Sama_2487
SBL: Sbal_3036
SBM: Shew185_3050
SBN: Sbal195_3193
SBP: Sbal223_1328
SLO: Shew_1126
SPC: Sputcn32_2697
SSE: Ssed_1222
SPL: Spea_1111
SHE: Shewmr4_1183
SHM: Shewmr7_1254
SHN: Shewana3_1184
SHW: Sputw3181_1314
SHL: Shal_1157 Shal_2709
SWD: Swoo_1322
SWP: swp_3683
ILO: IL0352
CPS: CPS_4729(glsA)
PHA: PSHAa2335
PAT: Patl_2048
SDE: Sde_2867
AMC: MADE_01329
LPN: lpg0241
LPF: lpl0295
LPP: lpp0311
LPC: LPC_0319
FTU: FTT_0195c
FTF: FTF0195c
FTW: FTW_1896
FTL: FTL_1900
FTH: FTH_1822(glsA)
FTA: FTA_2007
FTN: FTN_0171(glsA)
FPH: Fphi_0653
HCH: HCH_06987
MMW: Mmwyl1_3795
AHA: AHA_3480
ASA: ASA_0837(glsA)
KKO: Kkor_0679
CVI: CV_4158
RSO: RSp1143(glsA)
RME: Rmet_3760
BMA: BMAA0814(glsA)
BML: BMA10229_0029(glsA)
BMN: BMA10247_A1594(glsA)
BPS: BPSS0628(glsA)
BPM: BURPS1710b_A2189(glsA)
BPL: BURPS1106A_A0842
BPD: BURPS668_A0934
BTE: BTH_II1788
BVI: Bcep1808_3320
BUR: Bcep18194_B0751
BCN: Bcen_3428
BCH: Bcen2424_4940
BCM: Bcenmc03_5348
BCJ: BCAM2176(glsA)
BAM: Bamb_4370
BAC: BamMC406_4887
BMU: Bmul_3676
BMJ: BMULJ_04841(glsA)
BXE: Bxe_B1127
BPH: Bphy_5773
BPY: Bphyt_5532
BGL: bglu_2g18170
BAV: BAV2794(glsA)
POL: Bpro_4370
VAP: Vapar_0137
ABU: Abu_2331(glsA)
SUN: SUN_0901
DDS: Ddes_0048
MLO: mlr0211
SME: SMc00486(glsA)
SMD: Smed_1513
ATU: Atu1859(glsA)
ATC: AGR_C_3412
ARA: Arad_2601(glsA)
AVI: Avi_1928(glsA)
RET: RHE_CH02311(glsA)
REC: RHECIAT_CH0002407(glsA)
RLE: RL2623(glsA)
RLT: Rleg2_1946
RLG: Rleg_2155
RHI: NGR_c16350(glsA)
LAS: CLIBASIA_00345(glsA)
BME: BMEII0907 BMEII0908
BMF: BAB2_0863
BMB: BruAb2_0841
BMC: BAbS19_II07970
BMS: BRA0340
BMT: BSUIS_B0346
BCS: BCAN_B0342
BMR: BMI_II336
BJA: bll3935 bll4798
BRA: BRADO3130
BBT: BBta_3570
RPA: RPA4211(glsA)
RPB: RPB_1403
RPC: RPC_1541
RPD: RPD_1383
RPT: Rpal_4692
XAU: Xaut_1163 Xaut_1550
AZC: AZC_3538
MEX: Mext_2375
MEA: Mex_1p2377(glsA)
MDI: METDI3156(glsA)
MRD: Mrad2831_3529
MET: M446_4570
MPO: Mpop_2331
MCH: Mchl_2652
MNO: Mnod_4504
MSL: Msil_1407 Msil_3725
CCR: CC_0276
CCS: CCNA_00278
CAK: Caul_4564
RDE: RD1_2684(glsA)
MMR: Mmar10_2917
SWI: Swit_2796
GOX: GOX2066
BSU: BSU02430(ybgJ) BSU14830(ylaM)
BHA: BH2627 BH2717
BAN: BA0499(glsA-1) BA3155(glsA-2)
BAR: GBAA0499(glsA-1) GBAA3155(glsA-2)
BAA: BA_1070 BA_3658
BAT: BAS0471 BAS2932
BAH: BAMEG_1455(glsA2) BAMEG_4109(glsA1)
BAI: BAA_0559(glsA1) BAA_3205(glsA2)
BCE: BC0481 BC3115
BCA: BCE_0553(glsA)
BCZ: BCZK0410(glsA) BCZK2857
BCR: BCAH187_A0555(glsA1) BCAH187_A3171(glsA2)
BCB: BCB4264_A0502(glsA1) BCB4264_A3142(glsA2)
BCU: BCAH820_0480(glsA1) BCAH820_3164(glsA2)
BCG: BCG9842_B2097(glsA2) BCG9842_B4820(glsA1)
BCQ: BCQ_0528(glsA) BCQ_2956
BCX: BCA_0519(glsA1)
BCY: Bcer98_0426
BTK: BT9727_0414(glsA) BT9727_2907
BTL: BALH_0436(glsA) BALH_2817
BWE: BcerKBAB4_0416
BLI: BL01786(glsA) BL02973(ylaM)
BLD: BLi00274(ybgJ) BLi01700(ylaM)
BCL: ABC0329
BAY: RBAM_002800(ybgJ) RBAM_014690(ylaM)
BPU: BPUM_0244(glsA1) BPUM_1374(gls)
OIH: OB0870
GKA: GK2125
GTN: GTNG_2024
GWC: GWCH70_2044
GYM: GYMC10_2662
GYC: GYMC61_2961
ESI: Exig_0473
EAT: EAT1b_2251
BBE: BBR47_22510(ylaM) BBR47_27390(glsA)
PJD: Pjdr2_4717
LJO: LJ0713
LJF: FI9785_579(glsA)
LGA: LGAS_0507
LRE: Lreu_0246 Lreu_1254
LRF: LAR_0237 LAR_1188
CPE: CPE0591 CPE1995
CPF: CPF_0571 CPF_2251
CPR: CPR_0557 CPR_1963
CTC: CTC00566
CDF: CD0558(glsA)
CDC: CD196_0499(glsA)
CDL: CDR20291_0483(glsA)
CBO: CBO2808(glsA)
CBA: CLB_2751
CBH: CLC_2684
CBY: CLM_3173
CBL: CLK_2195
CBB: CLD_1766
CBI: CLJ_B3035
CBF: CLI_2858
AMT: Amet_3642
AOE: Clos_2008
APR: Apre_0305
NTH: Nther_0299
MSM: MSMEG_3818
MUL: MUL_3484(glsA)
MGI: Mflv_2331
MMI: MMAR_1548(glsA)
CGL: NCgl2395(cgl2482)
CGB: cg2728(glsK)
CGT: cgR_2392
CEF: CE2375
CUR: cur_1153(glsK)
CAR: cauri_1708(glsK)
CKP: ckrop_1575(glsA)
RHA: RHA1_ro06842
RER: RER_28350(glsA)
ROP: ROP_68270(glsA)
GBR: Gbro_0080 Gbro_1945
SCO: SCO7049(SC4G1.15)
SMA: SAV_1314(glsA)
SGR: SGR_5040 SGR_6768 SGR_683
CMI: CMM_0029(glsA)
ART: Arth_3548 Arth_3926
AAU: AAur_0360 AAur_3079
ACH: Achl_3622
KRH: KRH_19010(glsA)
MLU: Mlut_04560 Mlut_22150
BFA: Bfae_06680
KSE: Ksed_00310
FRE: Franean1_0296
NML: Namu_0555
SEN: SACE_1670(glsA)
CAI: Caci_7656
SHI: Shel_25660
SUS: Acid_0446 Acid_5408
BTH: BT_2571
BFR: BF0455
BFS: BF0394(glsA)
BVU: BVU_1414 BVU_3896
PDI: BDI_0820
CHU: CHU_1741(yneH)
GFO: GFO_2730(glsA)
COC: Coch_0977
RBI: RB2501_12102
FNU: FN1397
AMU: Amuc_0038
TAI: Taci_0795
SYN: slr2079
TEL: tlr0598
MAR: MAE_37760 MAE_60410
CYT: cce_2244 cce_2765
CYP: PCC8801_1435 PCC8801_3446
CYC: PCC7424_0451 PCC7424_1640
CYN: Cyan7425_0660 Cyan7425_1969 Cyan7425_2799
CYH: Cyan8802_1461 Cyan8802_2670
ANA: all2934 all4774
NPU: Npun_F3815 Npun_F6494
AVA: Ava_0966 Ava_2446
TER: Tery_3991
AMR: AM1_0365
Taxonomy
Structures PDB: 1MKI  1U60  2OSU  2PBY  3BRM  3CZD  3IF5  3IH8  3IH9  3IHA  
     3IHB  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5800436]
Kung HF, Wagner C.
Gamma-glutamylmethylamide. A new intermediate in the metabolism of
methylamine.
J. Biol. Chem. 244 (1969) 4136-40.
Pseudomonas sp.
Reference
  Authors
  Title
  Journal

 2
Roberts, E.
Glutaminase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 285-300.
Other DBs ExplorEnz - The Enzyme Database: 3.5.1.2
IUBMB Enzyme Nomenclature: 3.5.1.2
ExPASy - ENZYME nomenclature database: 3.5.1.2
BRENDA, the Enzyme Database: 3.5.1.2
CAS: 9001-47-2
DBGET integrated database retrieval system