KEGG ENZYME: 3.5.1.24

ENZYME: 3.5.1.24

Entry

EC 3.5.1.24 Enzyme

Name

choloylglycine hydrolase;
glycocholase;
bile salt hydrolase;
choloyltaurine hydrolase;
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

glycocholate amidohydrolase

Reaction(IUBMB)

glycocholate + H2O = cholate + glycine [RN:R05835]

Reaction(KEGG)

R05835;
(other) R02797 R03975 R03977 R04486 R04487

Substrate

glycocholate [CPD:C01921];
H2O [CPD:C00001]

Product

cholate [CPD:C00695];
glycine [CPD:C00037]

Comment

Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine.

Pathway

ec00120	Primary bile acid biosynthesis
ec00121	Secondary bile acid biosynthesis
ec01100	Metabolic pathways

Orthology

K01442

choloylglycine hydrolase

Genes

ECY:	ECSE_P3-0046
EUN:	UMNK88_pK8826
YEP:	YE105_C3212
YEY:	Y11_23571
ECA:	ECA3205
PCT:	PC1_2991
PCC:	PCC21_030280
PWA:	Pecwa_1281
PEC:	W5S_1189
ETA:	ETA_01240
SMAF:	D781_4527
PMR:	PMI1408 PMI2118
PSI:	S70_04090
MMK:	MU9_3111
EBF:	D782_2912
SML:	Smlt2151
SMT:	Smal_1745
BUJ:	BurJV3_1803
SMZ:	SMD_1934
VCH:	VCA0877
VCE:	Vch1786_II0565
VCJ:	VCD_000455
VCO:	VC0395_0360
VCR:	VC395_A0901
VCM:	VCM66_A0836
VCI:	O3Y_17603
VVM:	VVMO6_04393
VHA:	VIBHAR_02193 VIBHAR_05258
VSP:	VS_II0926
VEX:	VEA_000470
VFI:	VF_A0241
VFM:	VFMJ11_A0276
PFL:	PFL_3019
ACI:	ACIAD2026
ACD:	AOLE_07025
ACC:	BDGL_001515(cbh)
SDN:	Sden_0442
SLO:	Shew_0681 Shew_2805
SPL:	Spea_3411
SHL:	Shal_0591 Shal_1849
SWD:	Swoo_2365 Swoo_4492
SWP:	swp_4537
SVO:	SVI_3766 SVI_3983
LPN:	lpg0804
LPU:	LPE509_02414
LPF:	lpl0837
LPP:	lpp0866
LPC:	LPC_2491
LPA:	lpa_01222
LPE:	lp12_0821
FTU:	FTT_1109 FTT_1234
FTF:	FTF1109 FTF1234
FTW:	FTW_0554 FTW_0710 FTW_1419
FTR:	NE061598_06405 NE061598_07145 NE061598_07425
FTT:	FTV_1061 FTV_1181
FTG:	FTU_1145 FTU_1265
FTL:	FTL_0710 FTL_1089
FTH:	FTH_0713
FTA:	FTA_0750 FTA_1148 FTA_1239
FTS:	F92_03900 F92_06005 F92_06490
FTI:	FTS_1150
FTM:	FTM_0867 FTM_1253
FTN:	FTN_1252
FCF:	FNFX1_0768 FNFX1_1294 FNFX1_1344
FCN:	FN3523_1111 FN3523_1320 FN3523_1370
FPH:	Fphi_1328 Fphi_1380
FRT:	F7308_0967 F7308_1021 F7308_1070
FNA:	OOM_0893
NWA:	Nwat_2949
TNI:	TVNIR_0286(cbh_[H])
HNA:	Hneap_2225
HEL:	HELO_2628
MME:	Marme_2666
OCE:	GU3_10500
AFE:	Lferr_2503
AFR:	AFE_2883
BVI:	Bcep1808_5029
BUR:	Bcep18194_B0916
BPY:	Bphyt_6641
BYI:	BYI23_D007510
BUK:	MYA_4191
PNU:	Pnuc_0697 Pnuc_1576
BPE:	BP0474
BPC:	BPTD_0460
BPER:	BN118_2663
BPA:	BPP3319
BPAR:	BN117_3283
BBR:	BB3770
BBM:	BN115_3442
BBH:	BN112_4645
BAV:	BAV0756
AXY:	AXYL_01668
DAC:	Daci_3467
DEL:	DelCs14_3356
CTT:	CtCNB1_1826
HAR:	HEAR1574
BPRC:	D521_1577
NSA:	Nitsa_1273
SUN:	SUN_1118 SUN_2455
DMA:	DMR_29580 DMR_42620
DSA:	Desal_0728
BBA:	Bd0665
BBAT:	Bdt_0632
BEX:	A11Q_1682
DPS:	DP1182
MXA:	MXAN_5407
MFU:	LILAB_18880
MSD:	MYSTI_07881
CCX:	COCOR_00840(yxeI)
SUR:	STAUR_7495
DBR:	Deba_2031
RFE:	RF_1137
MLO:	mlr8141
ATU:	Atu4586
AGR:	AGROH133_14008
RLE:	RL1145
BME:	BMEI0543
BMI:	BMEA_A1518
BMZ:	BM28_A1479
BMG:	BM590_A1467
BMW:	BMNI_I1418
BMF:	BAB1_1488
BMB:	BruAb1_1463
BMC:	BAbS19_I13900
BAA:	BAA13334_I01625
BMS:	BR1468
BSI:	BS1330_I1462
BMT:	BSUIS_A1521
BSV:	BSVBI22_A1462
BOV:	BOV_1422
BCS:	BCAN_A1503
BSK:	BCA52141_I2834
BMR:	BMI_I1480
BPP:	BPI_I1520
OAN:	Oant_1699 Oant_1703
RPA:	RPA1879
RPB:	RPB_3497
RPC:	RPC_3412
RPD:	RPD_1956
RPE:	RPE_3554
RPT:	Rpal_2085
RPX:	Rpdx1_3637
NWI:	Nwi_0876
OCA:	OCAR_7036
OCG:	OCA5_c10580
OCO:	OCA4_c10580
XAU:	Xaut_2127 Xaut_2364 Xaut_4334
AZC:	AZC_0211 AZC_1021
SNO:	Snov_3157
MEX:	Mext_3821
MEA:	Mex_1p4190
MDI:	METDI4801
MCH:	Mchl_4129
BID:	Bind_1447 Bind_1920
MSL:	Msil_3557
HDN:	Hden_0817
HDT:	HYPDE_41773
RVA:	Rvan_1189
MSC:	BN69_3294
PDE:	Pden_0911
PSF:	PSE_3526
GDI:	GDI_0213
GDJ:	Gdia_2282
BSU:	BSU39540(yxeI)
BSR:	I33_4122
BSL:	A7A1_1988
BSH:	BSU6051_39540(yxeI)
BSY:	I653_19430
BSS:	BSUW23_19725(yxeI)
BST:	GYO_4361
BSO:	BSNT_06064(yxeI)
BSN:	BSn5_10795
BSQ:	B657_39540(yxeI)
BSUB:	BEST7613_1555 BEST7613_7109(yxeI)
BSX:	C663_3873
BLI:	BL00216(yxeI)
BLD:	BLi04217(yxeI)
BAO:	BAMF_3707(yxeI)
BAY:	RBAM_035950(yxeI)
BAQ:	BACAU_3617(yxeI)
BYA:	BANAU_3777(yxeI)
BAMP:	B938_18415
BAML:	BAM5036_3515(yxeI)
BAZ:	BAMTA208_19605(yxeI)
BQL:	LL3_04025(yxeI)
BXH:	BAXH7_04020(yxeI)
BQY:	MUS_4270(yxeI)
BAMI:	KSO_001120
BAE:	BATR1942_17775
BAN:	BA_3898
BAR:	GBAA_3898
BAT:	BAS3611
BAH:	BAMEG_0733
BAI:	BAA_3923
BAX:	H9401_3712
BAL:	BACI_c37120(cbaH)
BCE:	BC1015
BCA:	BCE_3801
BCR:	BCAH187_A3807
BCB:	BCB4264_A1046
BCU:	BCAH820_3779
BCG:	BCG9842_B4255
BCQ:	BCQ_3553(cbaH)
BCX:	BCA_3864
BNC:	BCN_3588
BCF:	bcf_18690
BCER:	BCK_16405
BTK:	BT9727_3508(cbaH)
BTL:	BALH_3395
BTB:	BMB171_C0890
BTT:	HD73_1165
BTC:	CT43_CH0954
BTF:	YBT020_18465
BTM:	MC28_G097
BTG:	BTB_c10700
BTI:	BTG_15890
BTN:	BTF1_02815
BTHT:	H175_ch0967
BWE:	BcerKBAB4_3538
BCO:	Bcell_1106
BJS:	MY9_4083
AXL:	AXY_05200
SAU:	SA0264
SAV:	SAV0275
SAW:	SAHV_0273
SAH:	SaurJH1_0266
SAJ:	SaurJH9_0259
SAM:	MW0251
SAS:	SAS0251
SAR:	SAR0272
SAC:	SACOL0262
SAX:	USA300HOU_0288
SAA:	SAUSA300_0269
SAO:	SAOUHSC_00247
SAE:	NWMN_0209
SAD:	SAAV_0243
SUU:	M013TW_0256
SUV:	SAVC_01120
SUH:	SAMSHR1132_02410
SUE:	SAOV_0216
SUJ:	SAA6159_00253
SUK:	SAA6008_00249
SUC:	ECTR2_236
SUT:	SAT0131_00270
SUQ:	HMPREF0772_10225
SUZ:	MS7_0266
SUD:	ST398NM01_0290
SUX:	SAEMRSA15_02340
SUW:	SATW20_02770
SUG:	SAPIG0290
SUF:	SARLGA251_02390
SAB:	SAB0214
SUY:	SA2981_0275
SAUB:	C248_0265
SAUM:	BN843_2750
SEP:	SE0350
SER:	SERP0227
SHA:	SH0297
SSP:	SSP0146
SCA:	Sca_0210
SLG:	SLGD_00283 SLGD_02308
SLN:	SLUG_02810 SLUG_22250
SWA:	A284_10405
LMO:	lmo0446 lmo2067
LMF:	LMOf2365_2098(cbH)
LMH:	LMHCC_0491
LMC:	Lm4b_02088
LMN:	LM5578_0479 LM5578_2268
LMY:	LM5923_0478 LM5923_2219
LMT:	LMRG_00138 LMRG_01217
LMG:	LMKG_00256 LMKG_01463
LMS:	LMLG_0361 LMLG_1979
LMJ:	LMOG_01160
LMQ:	LMM7_2157(bsh)
LML:	lmo4a_2118(bsh)
LMP:	MUO_10605
LMW:	LMOSLCC2755_0451 LMOSLCC2755_2129(bsh)
LMX:	LMOSLCC2372_0450 LMOSLCC2372_2133(bsh)
LMZ:	LMOSLCC2482_0450 LMOSLCC2482_2125(bsh)
LMON:	LMOSLCC2376_0445 LMOSLCC2376_2021(bsh)
LMOC:	LMOSLCC5850_0448 LMOSLCC5850_2128(bsh)
LMOS:	LMOSLCC7179_2038(bsh)
LMOO:	LMOSLCC2378_2091(bsh)
LMOY:	LMOSLCC2479_0449 LMOSLCC2479_2130(bsh)
LMOT:	LMOSLCC2540_2160(bsh)
LMOA:	LMOATCC19117_2087(bsh)
LMOL:	LMOL312_2080(bsh)
LMOG:	BN389_20960(cbh)
LSG:	lse_2056(bsh)
LIV:	LIV_2050(bsh)
LSP:	Bsph_3261
LLA:	L86424(pacB)
LLK:	LLKF_1160(pacA) LLKF_2027(pacB)
LLT:	CVCAS_1106(pacA) CVCAS_1771(pacB)
LLS:	lilo_1036(pacA) lilo_1838(pacB)
LLM:	llmg_1422(pacA)
LLR:	llh_6275
LLN:	LLNZ_07335
LGR:	LCGT_0048
LGV:	LCGL_0048
SGA:	GALLO_0818(bsh)
SGG:	SGGBAA2069_c07920(bsh)
SGT:	SGGB_0803(bsh)
STB:	SGPB_0678(bsh)
SIF:	Sinf_0639(bsh)
LPL:	lp_0067(pva1) lp_2572(pva3) lp_3362(pva2) lp_3536(bsh1)
LPJ:	JDM1_0076(bsh2) JDM1_2068(bsh4) JDM1_2695(bsh3) JDM1_2822(bsh1)
LPT:	zj316_0023(pva2) zj316_0150(cbh) zj316_0281(pva1) zj316_2493(pva3)
LPS:	LPST_C0055(bsh2) LPST_C2118(bsh4) LPST_C2764(bsh3) LPST_C2886(bsh1)
LJO:	LJ0056 LJ1147 LJ1412
LJF:	FI9785_1052 FI9785_118(cbsHbeta) FI9785_854
LJH:	LJP_0064c LJP_0828 LJP_1011c
LAC:	LBA0892(bshA) LBA1078(bshB)
LAI:	LAC30SC_04505 LAC30SC_05780
LAD:	LA14_0914 LA14_1092
LSA:	LSA0210
LSL:	LSL_0518 LSL_1801
LSI:	HN6_00474 HN6_01574
LDE:	LDBND_0852(cbh)
LDL:	LBU_0821
LBR:	LVIS_1801 LVIS_1962 LVIS_2132
LBK:	LVISKB_0731 LVISKB_1785 LVISKB_1943 LVISKB_2189
LCA:	LSEI_0412
LCB:	LCABL_04870(pac)
LCZ:	LCAZH_0447
LCS:	LCBD_0484
LCE:	LC2W_0486
LCW:	BN194_04910
LGA:	LGAS_0054 LGAS_0959
LRE:	Lreu_0730
LRF:	LAR_0701
LRU:	HMPREF0538_21983(cbh) HMPREF0538_21984(cbh2)
LHL:	LBHH_1220(cbh)
LHR:	R0052_06095
LFE:	LAF_0028 LAF_0941
LFR:	LC40_0019 LC40_0616
LRH:	LGG_00501
LRG:	LRHM_0484
LRL:	LC705_00493
LRA:	LRHK_509
LCR:	LCRIS_00906(cbh)
LAM:	LA2_04690 LA2_06130
LAY:	LAB52_04465 LAB52_05565
LBH:	Lbuc_0220 Lbuc_0500 Lbuc_1960
LBN:	LBUCD034_0261(bsh) LBUCD034_0536 LBUCD034_2047
LRM:	LRC_01740
EFA:	EF0521
EFL:	EF62_0089 EF62_0879(cbh)
EFI:	OG1RF_12285(cbh)
EFD:	EFD32_0436 EFD32_1847(cbh1) EFD32_2583
EFS:	EFS1_0461 EFS1_2439
EFC:	EFAU004_01892
EFU:	HMPREF0351_11857(cbh3)
EFM:	M7W_1078 M7W_1119
EHR:	EHR_09940 EHR_11510
ENE:	ENT_27500
ECAS:	ECBG_02025
OOE:	OEOE_1038
CRN:	CAR_c22540(cbh)
CML:	BN424_1697(yuhH) BN424_2932 BN424_357(azlC) BN424_362(aldR)
WKO:	WKK_03790
CPE:	CPE0709(cbh)
CPF:	CPF_0705 CPF_1348
CPR:	CPR_1155
CBK:	CLL_A2615
CBB:	CLD_2374
CBN:	CbC4_5025
CBT:	CLH_2377
CBF:	CLI_2250
CBM:	CBF_2236
CBJ:	H04402_02216
CBE:	Cbei_3673
CSH:	Closa_0510
CSO:	CLS_22920
CLS:	CXIVA_19040
CSR:	Cspa_c31260
ASF:	SFBM_1014
ASM:	MOUSESFB_0946
DSY:	DSY3579
FMA:	FMG_0420
EEL:	EUBELI_01636 EUBELI_20651
ERE:	EUBREC_2835
ERT:	EUR_24390
ERA:	ERE_09840
ELM:	ELI_1322 ELI_1856
ESR:	ES1_16780
ESU:	EUS_14970
AWO:	Awo_c31760(yxeI1)
CLE:	Clole_2713
RHO:	RHOM_14915 RHOM_15180
RIX:	RO1_19550 RO1_33910
RIM:	ROI_05990 ROI_07010
COO:	CCU_14250
CCT:	CC1_30750
RBR:	RBR_10200
RUM:	CK1_27720 CK1_38360
ROB:	CK5_10630 CK5_18830
OVA:	OBV_03870
BPRS:	CK3_08870
BPRL:	CL2_15710
TNR:	Thena_0101
ERH:	ERH_0215 ERH_1696
EUC:	EC1_18050
MSM:	MSMEG_5454
MSG:	MSMEI_5304
MVA:	Mvan_5516
MGI:	Mflv_1302
MSP:	Mspyr1_48770
MJD:	JDM601_3721
MMI:	MMAR_2570
MRH:	MycrhN_3292
MLI:	MULP_02295
ASD:	AS9A_1103
RER:	RER_12140
GBR:	Gbro_0747
KSK:	KSE_12560
NML:	Namu_5004
BLO:	BL0796
BLJ:	BLD_0536(cbaH)
BLN:	Blon_1453
BLON:	BLIJ_1499
BLF:	BLIF_0937
BLL:	BLJ_0948
BLB:	BBMN68_536(cbaH)
BLM:	BLLJ_0817
BLK:	BLNIAS_01547
BLG:	BIL_10200
BAD:	BAD_0856
BLA:	BLA_1379
BLC:	Balac_0863(bsh)
BLT:	Balat_0863(bsh)
BBB:	BIF_00207
BBC:	BLC1_0823
BNM:	BALAC2494_00268
BLV:	BalV_0829(bsh)
BLW:	W7Y_0865
BLS:	W91_0886
BNI:	BANAN_04270
BDE:	BDP_1106(cbh)
BBI:	BBIF_0879(cbh)
BBP:	BBPR_0850(cbh)
BBF:	BBB_0854(cbh)
BBV:	HMPREF9228_0895
BBRU:	Bbr_0971(cbh) Bbr_1520(pacB)
BTP:	D805_0402
GVG:	HMPREF0421_21234(pac)
GVH:	HMPREF9231_0294
SHI:	Shel_12270
CGO:	Corgl_1392
PUV:	PUV_01710(yxeI)
WCH:	wcw_0521
SNG:	SNE_A17210
BFR:	BF3794
BFS:	BF1508(cbh)
BFG:	BF638R_3610
BVU:	BVU_2699 BVU_3993
BSA:	Bacsa_1560
BXY:	BXY_10230 BXY_12160 BXY_36170
PDI:	BDI_0350 BDI_0767 BDI_1550
AFD:	Alfi_1795 Alfi_2825
ASH:	AL1_02020
PSN:	Pedsa_3564
SHG:	Sph21_1970
EVI:	Echvi_3323
CHU:	CHU_2387
FBC:	FB2170_15483
STR:	Sterm_3501
RBA:	RB2202
PSL:	Psta_3338
PLM:	Plim_0690 Plim_1884
PBS:	Plabr_2927
SYN:	slr1772
SYZ:	MYO_12040
SYY:	SYNGTS_0204(slr1772)
SYT:	SYNGTI_0204(slr1772)
SYS:	SYNPCCN_0204(slr1772)
SYQ:	SYNPCCP_0204(slr1772)
SYF:	Synpcc7942_2150
SYG:	sync_1125
SYNE:	Syn6312_1450
CYC:	PCC7424_4062
CYJ:	Cyan7822_3881 Cyan7822_6530
CAN:	Cyan10605_3351
CSN:	Cyast_0203
GLP:	Glo7428_0744
CSG:	Cylst_4756
SCS:	Sta7437_1908
MPG:	Theba_0190
MPI:	Mpet_2684
MST:	Msp_0760
MSI:	Msm_0986
MRU:	mru_1368
HTU:	Htur_3119
NMG:	Nmag_0839
NAT:	NJ7G_1002
NPE:	Natpe_0298
NGE:	Natgr_3005
MAX:	MMALV_06570 MMALV_11870

» show all

Reference

1 [PMID:6016335]

Authors

Nair PP, Gordon M, Reback J.

Title

The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.

Journal

J. Biol. Chem. 242 (1967) 7-11.

Organism

Clostridium perfringens

Reference

2 [PMID:10993]

Authors

Stellwag EJ, Hylemon PB.

Title

Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis.

Journal

Biochim. Biophys. Acta. 452 (1976) 165-76.

Organism

Bacteroides fragilis

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.24

IUBMB Enzyme Nomenclature:

3.5.1.24

ExPASy - ENZYME nomenclature database:

3.5.1.24

BRENDA, the Enzyme Database:

3.5.1.24

CAS:

37289-07-9

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Ontology (2)   
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Gene (12996)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (617)   
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   KEGG MGENES (12376)   
Protein sequence (616)   
   UniProt (303)   
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DNA sequence (675)   
   RefSeq(nuc) (345)   
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