| Entry |
|
|---|
| Name |
choloylglycine hydrolase;
glycocholase;
bile salt hydrolase;
choloyltaurine hydrolase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
 |
|---|
| Sysname |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine
amidohydrolase |
|---|
| Reaction(IUBMB) |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O =
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine
[RN:R05835] |
|---|
| Reaction(KEGG) |
R05835;
(other) R02797 R03975 R03977 R04486 R04487
 |
|---|
| Substrate |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine
[CPD:C01921];
H2O [CPD:C00001] |
|---|
| Product |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate [CPD:C00695];
glycine [CPD:C00037] |
|---|
| Comment |
Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on
choloyl-taurine. |
|---|
| Pathway |
PATH: ec00120 Primary bile acid biosynthesis
PATH: ec00121 Secondary bile acid biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01442 choloylglycine hydrolase |
|---|
| Genes |
ECY: ECSE_P3-0046
ECA: ECA3205
PCT: PC1_2991
PWA: Pecwa_1281
ETA: ETA_01240
PMR: PMI1408 PMI2118
SML: Smlt2151
SMT: Smal_1745
VCH: VCA0877
VCO: VC0395_0360
VCM: VCM66_A0836
VCJ: VCD_000455
VHA: VIBHAR_02193 VIBHAR_05258
VSP: VS_II0926
VEX: VEA_000470
VFI: VF_A0241
VFM: VFMJ11_A0276 VFMJ11_A0847
PFL: PFL_3019
ACI: ACIAD2026
SDN: Sden_0442
SLO: Shew_2805
SPL: Spea_3411
SHL: Shal_0591 Shal_1849
SWD: Swoo_2365 Swoo_4492
SWP: swp_4537
LPN: lpg0804
LPF: lpl0837
LPP: lpp0866
LPC: LPC_2491
FTU: FTT_1234
FTF: FTF1234
FTW: FTW_0710
FTL: FTL_0710 FTL_1089
FTH: FTH_0713
FTA: FTA_0750 FTA_1148 FTA_1239
FTM: FTM_0867 FTM_1253
FTN: FTN_1252
FPH: Fphi_1328 Fphi_1380
HNA: Hneap_2225
AFE: Lferr_2503
AFR: AFE_2883
BVI: Bcep1808_5029
BPY: Bphyt_6641
PNU: Pnuc_0643 Pnuc_0697 Pnuc_1576
BPE: BP0474
BPA: BPP3319
BBR: BB3770
BAV: BAV0756
DAC: Daci_3467
CTT: CtCNB1_1826
HAR: HEAR1574
SUN: SUN_1118 SUN_2455
DMA: DMR_29580 DMR_42620
DSA: Desal_0728
BBA: Bd0665
DPS: DP1182
MLO: mlr8141
ATU: Atu4586
ATC: AGR_L_573
RLE: RL1145
BME: BMEI0543
BMF: BAB1_1488
BMB: BruAb1_1463
BMC: BAbS19_I13900
BMS: BR1468
BMT: BSUIS_A1521
BOV: BOV_1422
BCS: BCAN_A1503
BMR: BMI_I1480
OAN: Oant_1699 Oant_1703
RPA: RPA1879
RPB: RPB_3497
RPC: RPC_3412
RPD: RPD_1956
RPE: RPE_3554
RPT: Rpal_2085
NWI: Nwi_0876
OCA: OCAR_7036
XAU: Xaut_2127 Xaut_2364 Xaut_4334
AZC: AZC_0211 AZC_1021
MEX: Mext_3821
MEA: Mex_1p4190
MDI: METDI4801
MCH: Mchl_4129
BID: Bind_1447 Bind_1920
MSL: Msil_3557
GDI: GDI_0213
GDJ: Gdia_2282
BAN: BA3898
BAR: GBAA3898
BAA: BA_4369
BAT: BAS3611
BAH: BAMEG_0733
BAI: BAA_3923
BCE: BC1015
BCA: BCE_3801
BCZ: pE33L466_0332
BCR: BCAH187_A3807
BCB: BCB4264_A1046
BCU: BCAH820_3779
BCG: BCG9842_B4255
BCQ: BCQ_3553(cbaH)
BCX: BCA_3864
BTK: BT9727_3508(cbaH)
BTL: BALH_3395
BWE: BcerKBAB4_3538
BAY: RBAM_035950(yxeI)
SAB: SAB0214
SAA: SAUSA300_0269
SCA: Sca_0210
LMO: lmo2067
LMF: LMOf2365_2098(cbh)
LMH: LMHCC_0491
LMC: Lm4b_02088
LSP: Bsph_3261
LLK: LLKF_1160(pacA) LLKF_2027(pacB)
LLM: llmg_1422(pacA)
LPL: lp_0067(bsh2) lp_2572(bsh4) lp_3362(bsh3) lp_3536(bsh1)
LPJ: JDM1_0076(bsh2) JDM1_2068(bsh4) JDM1_2695(bsh3) JDM1_2822(bsh1)
LJO: LJ0056 LJ1147 LJ1412
LJF: FI9785_1052 FI9785_118(cbsHbeta) FI9785_854
LAC: LBA0892(bshA) LBA1078(bshB)
LSA: LSA0210
LSL: LSL_0518 LSL_1801
LBR: LVIS_1801 LVIS_1962 LVIS_2132
LCA: LSEI_0412
LCB: LCABL_04870(pac)
LGA: LGAS_0054 LGAS_0959
LRE: Lreu_0730
LRF: LAR_0701
LFE: LAF_0028 LAF_0941
LRH: LGG_00501
LRL: LC705_00493
EFA: EF0521
CPE: CPE0709(cbh)
CPF: CPF_0705 CPF_1348
CPR: CPR_1155
CBK: CLL_A2615
CBB: CLD_2374
CBT: CLH_2377
CBF: CLI_2250
CBE: Cbei_3673
DSY: DSY3579
FMA: FMG_0420
EEL: EUBELI_01636 EUBELI_20651
ERE: EUBREC_2835
MSM: MSMEG_5454
MVA: Mvan_5516
MGI: Mflv_1302
MMI: MMAR_2570
RER: RER_12140
GBR: Gbro_0747
NML: Namu_5004
BLO: BL0796
BLJ: BLD_0536(cbaH)
BLN: Blon_1453
BAD: BAD_0856
BLA: BLA_1379
BLC: Balac_0863(bsh)
BLT: Balat_0863(bsh)
SHI: Shel_12270
BFR: BF3794
BFS: BF1508(cbh)
BVU: BVU_2699 BVU_3993
PDI: BDI_0350 BDI_0767 BDI_1550
CHU: CHU_2387
STR: Sterm_3501
SYG: sync_1125
CYC: PCC7424_4062
MST: Msp_0760
MSI: Msm_0986
 |
|---|
| Structures |
PDB: 2BJF 2BJG 2HEZ 2HF0 2RF8 2RG2 2RLC |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6016335]
Nair PP, Gordon M, Reback J.
The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha,
7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.
J. Biol. Chem. 242 (1967) 7-11.
Clostridium perfringens |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10993]
Stellwag EJ, Hylemon PB.
Purification and characterization of bile salt hydrolase from
Bacteroides fragilis subsp. fragilis.
Biochim. Biophys. Acta. 452 (1976) 165-76.
Bacteroides fragilis |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.1.24
IUBMB Enzyme Nomenclature: 3.5.1.24
ExPASy - ENZYME nomenclature database: 3.5.1.24
BRENDA, the Enzyme Database: 3.5.1.24
CAS: 37289-07-9 |
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