KEGG   ENZYME: 3.5.1.36Help
Entry
EC 3.5.1.36                 Enzyme                                 

Name
N-methyl-2-oxoglutaramate hydrolase;
5-hydroxy-N-methylpyroglutamate synthase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-methyl-2-oxoglutaramate methylamidohydrolase
Reaction(IUBMB)
N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine [RN:R01587]
Reaction(KEGG)
Substrate
N-methyl-2-oxoglutaramate [CPD:C03623];
H2O [CPD:C00001]
Product
2-oxoglutarate [CPD:C00026];
methylamine [CPD:C00218]
Comment
In the reverse reaction, the product cyclizes non-enzymically to 2-hydroxy-N-methyl-5-oxoproline.
History
EC 3.5.1.36 created 1972
Reference
1  [PMID:5470822]
  Authors
Hersh LB.
  Title
5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action.
  Journal
J. Biol. Chem. 245 (1970) 3526-35.
  Organism
Pseudomonas sp.
Reference
2  [PMID:5808511]
  Authors
Hersh LB, Tsai L, Stadtman ER.
  Title
The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid.
  Journal
J. Biol. Chem. 244 (1969) 4677-83.
  Organism
Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-53-4

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