KEGG   ENZYME: 3.5.1.38Help
Entry
EC 3.5.1.38                 Enzyme                                 
Name glutamin-(asparagin-)ase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname L-glutamine(L-asparagine) amidohydrolase
Reaction(IUBMB) L-glutamine + H2O = L-glutamate + NH3 [RN:R00256]
Reaction(KEGG) R00256;
(other) R00485 R00490 R01579 R06134
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Substrate L-glutamine [CPD:C00064];
H2O [CPD:C00001]
Product L-glutamate [CPD:C00025];
NH3 [CPD:C00014]
Comment L-Asparagine is hydrolysed at 0.8 of the rate of L-glutamine; the
D-isomers are also hydrolysed, but more slowly.
Pathway PATH: ec00250  Alanine, aspartate and glutamate metabolism
PATH: ec00471  D-Glutamine and D-glutamate metabolism
PATH: ec00910  Nitrogen metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K05597  glutamin-(asparagin-)ase
Genes PAE: PA1337(ansB)
PAU: PA14_46970(ansB)
PAP: PSPA7_4048(ansB)
PAG: PLES_38441(ansB)
PPU: PP_2453(ansA)
PPF: Pput_3237
PPG: PputGB1_3493
PPW: PputW619_1955
PFL: PFL_2099(ansB)
PFO: Pfl01_1917
PFS: PFLU4161
PEN: PSEEN1951(aspQ)
AVN: Avin_07280
ACI: ACIAD2088(aspQ)
ACB: A1S_1466
ABM: ABSDF2183(aspQ)
ABY: ABAYE2188(aspQ)
ABC: ACICU_01504
ABN: AB57_1697
ABB: ABBFA_002021
REU: Reut_A1812
REH: H16_A1910(ansA)
RME: Rmet_1583
CTI: RALTA_A1603(ansB1)
BXE: Bxe_B2492
BPY: Bphyt_4228
POL: Bpro_4206
PNA: Pnap_0442
AAV: Aave_4182
AJS: Ajs_3863
DAC: Daci_0564
DIA: Dtpsy_3136
VAP: Vapar_4748
CTT: CtCNB1_0406
MPT: Mpe_A1913
LCH: Lcho_2689
AZO: azo0438(ansB2)
APP: CAP2UW1_1093
MRD: Mrad2831_3427
MET: M446_5042
MNO: Mnod_5349
Taxonomy
Structures PDB: 1DJO  1DJP  4PGA  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5017769]
Roberts J, Holcenberg JS, Dolowy WC.
Isolation, crystallization, and properties of Achromobacteraceae
glutaminase-asparaginase with antitumor activity.
J. Biol. Chem. 247 (1972) 84-90.
Achromobacferaceae sp.
Other DBs ExplorEnz - The Enzyme Database: 3.5.1.38
IUBMB Enzyme Nomenclature: 3.5.1.38
ExPASy - ENZYME nomenclature database: 3.5.1.38
BRENDA, the Enzyme Database: 3.5.1.38
CAS: 39335-03-0
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