KEGG   ENZYME: 3.5.1.4Help
Entry
EC 3.5.1.4                  Enzyme                                 
Name amidase;
acylamidase;
acylase;
amidohydrolase;
deaminase;
fatty acylamidase;
N-acetylaminohydrolase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname acylamide amidohydrolase
Reaction(IUBMB) a monocarboxylic acid amide + H2O = a monocarboxylate + NH3
[RN:R03909]
Reaction(KEGG) R03909 > R00321 R02540 R03096 R03180 R05551 R05590;
(other) R06134
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Substrate monocarboxylic acid amide [CPD:C03620];
H2O [CPD:C00001]
Product monocarboxylate [CPD:C00060];
NH3 [CPD:C00014]
Pathway PATH: ec00330  Arginine and proline metabolism
PATH: ec00360  Phenylalanine metabolism
PATH: ec00380  Tryptophan metabolism
PATH: ec00460  Cyanoamino acid metabolism
PATH: ec00632  Benzoate degradation via CoA ligation
PATH: ec00643  Styrene degradation
PATH: ec01070  Biosynthesis of plant hormones
Orthology KO: K01426  amidase
Genes BFO: BRAFLDRAFT_94568
DPO: Dpse_GA20671 Dpse_GA20678
NVE: NEMVE_v1g114332
SCE: YDR242W(AMD2)
DHA: DEHA0E24684g
PIC: PICST_43525(AMI1) PICST_47832(AMD2) PICST_48268(AMD4)
     PICST_87495(GTA2)
SPO: SPBPB8B6.03
NCR: NCU10409
MGR: MGG_01918 MGG_05827 MGG_11270
FGR: FG10318.1
ANI: AN8777.2
AFM: AFUA_1G14880 AFUA_5G00470 AFUA_5G09140 AFUA_6G08000
AOR: AO090003000129
ANG: An07g03960 An11g02980
NFI: NFIA_053700
SSL: SS1G_14033
BFU: BC1G_07470 BC1G_14633
LBC: LACBIDRAFT_252664
MGL: MGL_3569
ECC: c2457
ECI: UTI89_C2212
ECP: ECP_1969
KPE: KPK_2671
CKO: CKO_00871
XCC: XCC0924(gatAX)
XCB: XC_3311
XAC: XAC1002(gatAX)
PAE: PA0202 PA0704 PA3366(amiE) PA4163 PA4342
PAU: PA14_10040 PA14_20560(amiE) PA14_55200 PA14_56450
PAP: PSPA7_0927 PSPA7_1764(amiE) PSPA7_4805 PSPA7_4912
PAG: PLES_07641 PLES_16981(amiE) PLES_46261 PLES_47201
PPU: PP_2932
PPF: Pput_2141(amiE) Pput_2609 Pput_2727 Pput_2760
PPG: PputGB1_2751 PputGB1_2840
PPW: PputW619_2551 PputW619_3079
PST: PSPTO_1357(amiE) PSPTO_2421(amdA)
PSB: Psyr_1170 Psyr_2208
PSP: PSPPH_1242 PSPPH_2976
PFL: PFL_1346 PFL_2778(gatA) PFL_3681 PFL_5178
PFO: Pfl01_1293 Pfl01_3257
PFS: PFLU3208
PEN: PSEEN2010 PSEEN2156
PMY: Pmen_0704 Pmen_1657
PCR: Pcryo_0431
ACI: ACIAD1618(amdA)
ACB: A1S_1283 A1S_1865
ABY: ABAYE1700 ABAYE2422
SON: SO_0888
SFR: Sfri_1616
SAZ: Sama_2522
SBL: Sbal_3131
SBM: Shew185_3140
SBN: Sbal195_3283
SBP: Sbal223_1233
SPC: Sputcn32_2761
SHE: Shewmr4_3287
SHM: Shewmr7_0660
SHN: Shewana3_3464
SHW: Sputw3181_1251
SWD: Swoo_4038
MAQ: Maqu_0245 Maqu_2108 Maqu_3862(amiE)
LPN: lpg2355 lpg2852(amiC)
LPF: lpl2277 lpl2764
LPP: lpp2304 lpp2910
LPC: LPC_1824 LPC_3137(amiC)
ABO: ABO_0120(amiC) ABO_1980(amiE) ABO_2482 ABO_2506
MMW: Mmwyl1_3197
AHA: AHA_0739
ASA: ASA_3615
RPI: Rpic_1411
RPF: Rpic12D_1453
REU: Reut_A1619 Reut_B3768 Reut_B4073 Reut_B4143
REH: H16_A1469 H16_A3386 H16_B1874 H16_B2307 H16_B2459(amiF)
RME: Rmet_0495 Rmet_1937 Rmet_3556 Rmet_4787
CTI: RALTA_B1573
BMA: BMA1864 BMAA1320 BMAA2061
BMV: BMASAVP1_0302 BMASAVP1_1087 BMASAVP1_A1098 BMASAVP1_A2603
BML: BMA10229_0577 BMA10229_1369 BMA10229_A0768
BMN: BMA10247_0172 BMA10247_0381 BMA10247_A0990 BMA10247_A2352
BPS: BPSL1183 BPSS0911 BPSS2307
BPM: BURPS1710b_1403 BURPS1710b_A1454(gatAX) BURPS1710b_A2509
BPL: BURPS1106A_1265 BURPS1106A_2972 BURPS1106A_A1252
     BURPS1106A_A3121
BPD: BURPS668_1257 BURPS668_A1324 BURPS668_A2332 BURPS668_A3236
BPR: GBP346_A1281
BTE: BTH_I1032 BTH_II0320 BTH_II0721 BTH_II1486
BVI: Bcep1808_0235 Bcep1808_5212 Bcep1808_7170(amiE)
BUR: Bcep18194_A3378 Bcep18194_B1131 Bcep18194_B1550
     Bcep18194_B1842(amiE) Bcep18194_B2503 Bcep18194_B2627
     Bcep18194_C6669 Bcep18194_C7043 Bcep18194_C7676
BCN: Bcen_0543 Bcen_2832 Bcen_3678 Bcen_3739(amiE) Bcen_4079
     Bcen_4892
BCH: Bcen2424_0275 Bcen2424_3272 Bcen2424_3512 Bcen2424_3612
     Bcen2424_4287 Bcen2424_4629(amiE) Bcen2424_4689 Bcen2424_6915
BCM: Bcenmc03_0257 Bcenmc03_3230 Bcenmc03_3908 Bcenmc03_4006
     Bcenmc03_5611 Bcenmc03_5675(amiE)
BCJ: BCAL0148 BCAM0538 BCAM0641 BCAM1315(amiE) BCAM1828
BAM: Bamb_0189 Bamb_2709 Bamb_3988 Bamb_4083 Bamb_5269 Bamb_5348
     Bamb_6072 Bamb_6315 Bamb_6405 Bamb_6547
BAC: BamMC406_0202 BamMC406_2583 BamMC406_3449 BamMC406_3518
     BamMC406_4547 BamMC406_6117 BamMC406_6261
BMU: Bmul_0183 Bmul_4003 Bmul_5086
BMJ: BMULJ_03081(amiE) BMULJ_03430(amiE) BMULJ_04501(amiE)
BXE: Bxe_B1059 Bxe_C1251
BPY: Bphyt_0390
PNU: Pnuc_1184
BPE: BP0722 BP1827 BP2039
BPA: BPP1726 BPP2879 BPP3676
BBR: BB3200 BB3382 BB4111
POL: Bpro_0385 Bpro_0413 Bpro_0571(amiE)
AAV: Aave_0191
AJS: Ajs_0886 Ajs_2586
VEI: Veis_0311 Veis_0353 Veis_1437 Veis_2464 Veis_3137
     Veis_4905(amiE)
DAC: Daci_2827 Daci_3641(amiE) Daci_5308
MPT: Mpe_A0772 Mpe_A1980 Mpe_A3614(amiE)
HAR: HEAR2119 HEAR3253
AZO: azo1956(amiD) azo2357
DAR: Daro_1360
MFA: Mfla_0463(amiE)
HPY: HP0294(amiE)
HPJ: jhp0279(amiE)
HPA: HPAG1_0296(amiE)
HPS: HPSH_01525(amiE)
HPG: HPG27_273(amiE)
HPP: HPP12_0293(amiE)
HAC: Hac_0554(amiE)
DOL: Dole_0166 Dole_1076
ADE: Adeh_2922 Adeh_3433
ACP: A2cp1_3583
ANK: AnaeK_3515
SCL: sce3176(gatA3)
MLO: mlr2310 mlr3187 mlr5350
MES: Meso_2296
PLA: Plav_0798 Plav_3043
SME: SMa1377 SMa2363
SMD: Smed_5337
ARA: Arad_8302
AVI: Avi_7092
RET: RHE_PB00103(ypb00060)
REC: RHECIAT_PC0000213
RLE: pRL90204
RLT: Rleg2_6359
BME: BMEII1134
BMF: BAB2_0097 BAB2_1061
BMB: BruAb2_0098 BruAb2_1042
BMS: BRA0099 BRA1103
OAN: Oant_3309
BJA: bll0198 bll0246(bam) bll3874 bll5806 bll6733 blr0973(amiE)
     blr7896
BRA: BRADO0324 BRADO0922 BRADO1531(amdA) BRADO1769(bam) BRADO2532
     BRADO4071 BRADO4399 BRADO4407 BRADO5789 BRADO5869(amiE)
BBT: BBta_0309 BBta_0724 BBta_1958(amiE) BBta_2081(bam) BBta_2877
     BBta_3796 BBta_4447 BBta_5240 BBta_6296 BBta_7130
RPA: RPA1700 RPA3440 RPA3628
RPB: RPB_0691 RPB_0940 RPB_1679 RPB_1820 RPB_1896 RPB_2085 RPB_2551
     RPB_3629
RPC: RPC_1671 RPC_3666
RPD: RPD_1043 RPD_1838 RPD_2905 RPD_3296 RPD_3471 RPD_4286 RPD_4294
RPE: RPE_3704
RPT: Rpal_1900 Rpal_4149
NHA: Nham_2690
AZC: AZC_2578
MEX: Mext_3372(amiE)
MDI: METDI4174(amiE)
MRD: Mrad2831_5504(amiE)
MET: M446_0600(amiE)
MPO: Mpop_3563(amiE)
MCH: Mchl_3681(amiE)
BID: Bind_1302
CCR: CC_1830 CC_2473
CAK: Caul_2154
SIL: SPO2583 SPO2938
SIT: TM1040_0870 TM1040_1577
RSP: RSP_3253 RSP_3526
RSH: Rsph17029_1064 Rsph17029_3170
RSQ: Rsph17025_2842
RSK: RSKD131_3694
JAN: Jann_1304 Jann_2532
PDE: Pden_3053
HNE: HNE_1334
NAR: Saro_0605
SWI: Swit_3120 Swit_3247 Swit_4169 Swit_4393
GBE: GbCGDNIH1_1839(amiE)
ACR: Acry_0243 Acry_1407 Acry_2933
RRU: Rru_A0983
MAG: amb1668
BAN: BA1921 BA2072 BA2596
BAR: GBAA1921 GBAA2072 GBAA2596
BAA: BA_3104
BAT: BAS1782 BAS1925 BAS2418
BAH: BAMEG_2001 BAMEG_2519 BAMEG_2669
BCE: BC2054 BC2537
BCA: BCE_2005 BCE_2143 BCE_2616
BCZ: BCZK1739(gatA) BCZK1877(gatA) BCZK2342
BCR: BCAH187_A2026 BCAH187_A2171 BCAH187_A2654
BCB: BCB4264_A1925 BCB4264_A2061 BCB4264_A2569
BCU: BCAH820_1957 BCAH820_2103 BCAH820_2613
BCG: BCG9842_B2755 BCG9842_B3247 BCG9842_B3418
BCQ: BCQ_1912(gatA) BCQ_2054(gatA) BCQ_2472
BCX: BCA_1987 BCA_2142 BCA_2685
BTK: BT9727_1761(gatA) BT9727_1887(gatA) BT9727_2377
BTL: BALH_1700 BALH_1831 BALH_2335
BWE: BcerKBAB4_1796 BcerKBAB4_1921 BcerKBAB4_2541
BCL: ABC3731
GKA: GK2270
LMO: lmo0849
LIN: lin0842
LWE: lwe2553
LLA: L169390(ybgE)
LLM: llmg_0177
SPY: SPy_0902(amiC)
SPZ: M5005_Spy_0705(amiC)
SPM: spyM18_0961(amiC)
SPG: SpyM3_0618(amiC)
SPS: SPs1235
SPH: MGAS10270_Spy0763(amiC)
SPI: MGAS10750_Spy0797(amiC)
SPJ: MGAS2096_Spy0777(amiC)
SPK: MGAS9429_Spy0761(amiC)
SPF: SpyM51103
SPA: M6_Spy0722
SPB: M28_Spy0685(amiC)
SOZ: Spy49_0714(amiC)
SAG: SAG1611
SAN: gbs1660
SMU: SMU.1218(nylA)
SSU: SSU05_0304
SSV: SSU98_0300
OOE: OEOE_1486
AMT: Amet_2922
MTU: Rv1263(amiB2) Rv2363(amiA2) Rv2888c(amiC) Rv3175 Rv3375(amiD)
MTC: MT1301 MT2432(nylA) MT2956 MT3264 MT3485
MRA: MRA_1271(amiB2) MRA_2387(amiA2) MRA_2913(amiC) MRA_3208
     MRA_3415(amiD)
MTF: TBFG_12389 TBFG_12902 TBFG_13196 TBFG_13411
MTB: TBMG_03218(TBMG_03218.1) TBMG_03426(TBMG_03426.1)
MBO: Mb1294(amiB2) Mb2384(amiA2) Mb2912c(amiC) Mb3200 Mb3409(amiD)
MBB: BCG_1322(amiB2) BCG_2377(amiA2) BCG_2909c(amiC) BCG_3199
     BCG_3446(amiD)
MBT: JTY_1297(amiB2) JTY_2904(amiC) JTY_3194 JTY_3446(amiD)
MLE: ML1596
MLB: MLBr_01596
MPA: MAP2143(amiA2) MAP2509c(amiB2) MAP2954c(amiC)
MAV: MAV_1414 MAV_2032
MSM: MSMEG_0485 MSMEG_1090 MSMEG_2521 MSMEG_3970 MSMEG_4492
MUL: MUL_2069(amiC) MUL_3616(amiA2) MUL_4478(amiB2)
MVA: Mvan_2213 Mvan_3155 Mvan_3824 Mvan_4052
MGI: Mflv_2712 Mflv_4130
MAB: MAB_0724c MAB_1674c MAB_2024
MMC: Mmcs_1841 Mmcs_1995 Mmcs_2705 Mmcs_3451 Mmcs_5150
MKM: Mkms_1888 Mkms_2041 Mkms_2749 Mkms_3514 Mkms_5239
MJL: Mjls_1822 Mjls_1976 Mjls_2735 Mjls_3462 Mjls_5531
MMI: MMAR_0984(amiD) MMAR_1821(amiC) MMAR_3673(amiA2)
CEF: CE0710
CJK: jk0917
NFA: nfa33260 nfa7560(amiE)
RHA: RHA1_ro00359(amdA) RHA1_ro01236 RHA1_ro02852 RHA1_ro03211
     RHA1_ro03496 RHA1_ro04008 RHA1_ro04406 RHA1_ro04575
     RHA1_ro04799 RHA1_ro05297 RHA1_ro10169(amiE)
RER: RER_04920(amiE) RER_59230(amdA)
ROP: ROP_09580 ROP_27980
SMA: SAV_6697 SAV_7269(amiE1) SAV_7345(amiE2)
SGR: SGR_2517
LXX: Lxx21950
AAU: AAur_0853 AAur_3573 AAur_pTC20148(amdA)
ACH: Achl_0058
NCA: Noca_0666 Noca_1228 Noca_1493 Noca_3358
TFU: Tfu_2207
FRA: Francci3_0175
FRE: Franean1_4139
FAL: FRAAL0331 FRAAL0363 FRAAL3665
ACE: Acel_1602
SEN: SACE_1914 SACE_4293 SACE_5032
STP: Strop_0921 Strop_3411 Strop_3520
SAQ: Sare_0864 Sare_3895
RXY: Rxyl_0238 Rxyl_0468 Rxyl_1701 Rxyl_1878
LIL: LA1333(amiC)
LIC: LIC12392(nylA)
ABA: Acid345_1493 Acid345_1685
SUS: Acid_0865 Acid_3497 Acid_6116
SRU: SRU_0414
SYN: sll0828(nylA)
CYA: CYA_2100
CYB: CYB_2659
ANA: all1235 all7525
AVA: Ava_4525
TER: Tery_1350 Tery_4203
RRS: RoseRS_1254
RCA: Rcas_2860
CAU: Caur_0592
CAG: Cagg_3400
CHL: Chy400_0639
DRA: DR_1377 DR_1625
NPH: NP0178A(aimE_2) NP4212A(amiE)
APE: APE_0979.1
SSO: SSO2122(gatA-3)
SIS: LS215_0377
SIA: M1425_0352
SIM: M1627_0353
SID: M164_0374
SIY: YG5714_0350
SIN: YN1551_2702
Taxonomy
Structures PDB: 2PLQ  2UXY  2VYA  2WAP  2WJ1  2WJ2  3A1I  3A1K  3HKX  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:16748573]
Bray HG, James SP, Raffan IM, Ryman BE, Thorpe WV.
The fate of certain organic acids and amides in the rabbit. 7. An
amidase of rabbit liver.
Biochem. J. 44 (1949) 618-25.
Oryctolagus cuniculus
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:14800883]
BRAY HG, JAMES SP, THORPE JW, WASDELL MR.
The fate of certain organic acids and amides in the rabbit; further
observations on the hydrolysis of amides by tissue extracts.
Biochem. J. 47 (1950) 294-9.
Oryctolagus cuniculus
Other DBs ExplorEnz - The Enzyme Database: 3.5.1.4
IUBMB Enzyme Nomenclature: 3.5.1.4
ExPASy - ENZYME nomenclature database: 3.5.1.4
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.4
BRENDA, the Enzyme Database: 3.5.1.4
CAS: 9012-56-0
DBGET integrated database retrieval system