| Entry |
|
|---|
| Name |
2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase;
compound B hydrolase;
alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid
hydrolase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
 |
|---|
| Sysname |
2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase
(deaminating, decarboxylating) |
|---|
| Reaction(IUBMB) |
2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O = acetate
+ 2-(hydroxymethyl)-4-oxobutanoate + NH3 + CO2 [RN:R04397] |
|---|
| Reaction(KEGG) |
R04397
 |
|---|
| Substrate |
2-(hydroxymethyl)-3-(acetamidomethylene)succinate [CPD:C04690];
H2O [CPD:C00001] |
|---|
| Product |
acetate [CPD:C00033];
2-(hydroxymethyl)-4-oxobutanoate [CPD:C04106];
NH3 [CPD:C00014];
CO2 [CPD:C00011] |
|---|
| Comment |
Involved in the degradation of pyridoxin by Pseudomonas and
Arthrobacter. |
|---|
| Pathway |
PATH: ec00750 Vitamin B6 metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3972793]
Huynh MS, Snell EE.
Enzymes of vitamin B6 degradation. Purification and properties of
two N-acetylamidohydrolases.
J. Biol. Chem. 260 (1985) 2379-83.
Pseudomonas sp., Arthrobacter sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.1.66
IUBMB Enzyme Nomenclature: 3.5.1.66
ExPASy - ENZYME nomenclature database: 3.5.1.66
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.66
BRENDA, the Enzyme Database: 3.5.1.66
CAS: 95829-26-8 |
|---|
