| Entry |
|
|---|
| Name |
arylformamidase;
kynurenine formamidase;
formylase;
formylkynureninase;
formylkynurenine formamidase;
formamidase I;
formamidase II |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
 |
|---|
| Sysname |
aryl-formylamine amidohydrolase |
|---|
| Reaction(IUBMB) |
N-formyl-L-kynurenine + H2O = formate + L-kynurenine [RN:R01959] |
|---|
| Reaction(KEGG) |
R01959;
(other) R00988 R04911
 |
|---|
| Substrate |
N-formyl-L-kynurenine [CPD:C02700];
H2O [CPD:C00001] |
|---|
| Product |
formate [CPD:C00058];
L-kynurenine [CPD:C00328] |
|---|
| Comment |
Also acts on other aromatic formylamines. |
|---|
| Pathway |
PATH: ec00380 Tryptophan metabolism
PATH: ec00630 Glyoxylate and dicarboxylate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01432 arylformamidase |
|---|
| Genes |
HSA: 125061(AFMID)
PTR: 740879(AFMID)
MCC: 715153
MMU: 71562(Afmid)
RNO: 688283(Afmid)
CFA: 609011(AFMID)
BTA: 518864(AFMID)
ECB: 100057858
MDO: 100031085
OAA: 100092470
GGA: 769005(AFMID)
TGU: 100226881
XTR: 100127853
DRE: 550372(afmid)
 |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:14907621]
HAYAISHI O, STANIER RY.
The bacterial oxidation of tryptophan. III. Enzymatic activities of
cell-free extracts from bacteria employing the aromatic pathway.
J. Bacteriol. 62 (1951) 691-709. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13163050]
JAKOBY WB.
Kynurenine formamidase from Neurospora.
J. Biol. Chem. 207 (1954) 657-63.
Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:14794728]
MEHLER AH, KNOX WE.
The conversion of tryptophan to kynurenine in liver. II. The
enzymatic hydrolysis of formylkynurenine.
J. Biol. Chem. 187 (1950) 431-8.
Rattus norvegicus [GN:rno], Oryctolagus cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.1.9
IUBMB Enzyme Nomenclature: 3.5.1.9
ExPASy - ENZYME nomenclature database: 3.5.1.9
BRENDA, the Enzyme Database: 3.5.1.9
CAS: 156229-75-3 |
|---|
