KEGG   ENZYME: 3.5.1.92Help
Entry
EC 3.5.1.92                 Enzyme                                 
Name
pantetheine hydrolase;
pantetheinase;
vanin;
vanin-1
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
(R)-pantetheine amidohydrolase
Reaction(IUBMB)
(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol [RN:R02973]
Reaction(KEGG)
Substrate
(R)-pantetheine [CPD:C00831];
H2O [CPD:C00001]
Product
(R)-pantothenate [CPD:C00864];
2-aminoethanethiol [CPD:C01678]
Comment
The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5].
Pathway
Pantothenate and CoA biosynthesis
Orthology
K08069  
pantetheine hydrolase
Genes
HSA: 
8875(VNN2) 8876(VNN1)
PTR: 
463007(VNN2) 746544(VNN1)
PPS: 
100978332(VNN1) 100979321(VNN2)
GGO: 
101125335(VNN1) 101126426(VNN2)
PON: 
100436777(VNN2) 100441056(VNN1)
MCC: 
708637(VNN2) 708830(VNN1)
MMU: 
22361(Vnn1)
RNO: 
29142(Vnn1)
CFA: 
442973(VNN1)
AML: 
FCA: 
101096984(VNN1)
BTA: 
526704(VNN1) 534929(VNN2)
SSC: 
100153984(VNN2) 397246(VNN1)
ECB: 
100067672(VNN2) 100146975(VNN1)
MDO: 
100031271 100031277
SHR: 
100933586(VNN1) 100934104
OAA: 
100074927 100075001(VNN2)
GGA: 
421702(VNN1)
MGP: 
100541961 100542733
TGU: 
100217969(VNN1) 100220807(VNN2)
ACS: 
100566816
XTR: 
496713(vnn2)
BFO: 
BRAFLDRAFT_278514
SPU: 
575770
NVE: 
NEMVE_v1g122468
TAD: 
TRIADDRAFT_21249
 » show all
Taxonomy
Reference
1  [PMID:440106]
  Authors
Dupre S, Cavallini D.
  Title
Purification and properties of pantetheinase from horse kidney.
  Journal
Methods. Enzymol. 62 (1979) 262-7.
  Organism
Equus caballus [GN:ecb]
Reference
2  [PMID:6549111]
  Authors
Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D.
  Title
Continuous spectrophotometric assay of pantetheinase activity.
  Journal
Anal. Biochem. 142 (1984) 175-81.
  Organism
Equus caballus [GN:ecb]
Reference
3  [PMID:10567687]
  Authors
Maras B, Barra D, Dupre S, Pitari G.
  Title
Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
  Journal
FEBS. Lett. 461 (1999) 149-52.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
Reference
4  [PMID:8934567]
  Authors
Aurrand-Lions M, Galland F, Bazin H, Zakharyev VM, Imhof BA, Naquet P.
  Title
Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing.
  Journal
Immunity. 5 (1996) 391-405.
  Organism
Homo sapiens [GN:hsa]
Reference
5  [PMID:11042271]
  Authors
Pitari G, Malergue F, Martin F, Philippe JM, Massucci MT, Chabret C, Maras B, Dupre S, Naquet P, Galland F.
  Title
Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.
  Journal
FEBS. Lett. 483 (2000) 149-54.
  Organism
Mus musculus [GN:mmu]
Reference
6  [PMID:11491533]
  Authors
Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F.
  Title
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
  Journal
Immunogenetics. 53 (2001) 296-306.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
Reference
7  [PMID:11380987]
  Authors
Pace HC, Brenner C.
  Title
The nitrilase superfamily: classification, structure and function.
  Journal
Genome. Biol. 2 (2001) REVIEWS0001.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56093-18-6
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