| Entry |
|
|---|
| Name |
gamma-glutamyl-gamma-aminobutyrate hydrolase;
gamma-glutamyl-GABA hydrolase;
PuuD;
YcjL;
4-(gamma-glutamylamino)butanoate amidohydrolase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
 |
|---|
| Sysname |
4-(glutamylamino)butanoate amidohydrolase |
|---|
| Reaction(IUBMB) |
4-(glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate
[RN:R07419] |
|---|
| Reaction(KEGG) |
R07419
 |
|---|
| Substrate |
4-(glutamylamino)butanoate [CPD:C15767];
H2O [CPD:C00001] |
|---|
| Product |
4-aminobutanoate [CPD:C00334];
L-glutamate [CPD:C00025] |
|---|
| Comment |
Forms part of a novel putrescine-utilizing pathway in Escherichia
coli, in which it has been hypothesized that putrescine is first
glutamylated to form gamma-glutamylputrescine, which is oxidized to
4-(gamma-glutamylamino)butanal and then to
4-(gamma-glutamylamino)butanoate. The enzyme can also catalyse the
reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine
hydrolase). |
|---|
| Pathway |
PATH: ec00330 Arginine and proline metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K09473 gamma-glutamyl-gamma-aminobutyrate hydrolase |
|---|
| Genes |
ECO: b1298(puuD)
ECJ: JW1291(puuD)
ECD: ECDH10B_1415(puuD)
EBW: BWG_1130(puuD)
ECE: Z2490(puuD)
ECS: ECs1875(puuD)
ECF: ECH74115_1940(puuD)
ETW: ECSP_1823(puuD)
ECW: EcE24377A_1508(puuD)
ECX: EcHS_A1413(puuD)
ECM: EcSMS35_1824(puuD)
ECY: ECSE_1350(puuD)
ECL: EcolC_2327(puuD)
ECK: EC55989_1460(puuD)
ECR: ECIAI1_1323(puuD)
ECT: ECIAI39_1649(puuD)
EUM: ECUMN_1604(puuD)
EBL: B21_01286(puuD)
EBD: ECBD_2319
EBR: ECB_01275(ycjL)
EOH: ECO103_1462(puuD)
EOI: ECO111_1681(puuD)
EOJ: ECO26_1865(puuD)
SFL: SF1303(puuD)
SFX: S1385(puuD)
SFV: SFV_1312(ycjL)
SSN: SSON_1842(puuD)
ESA: ESA_02079(puuD)
CTU: Ctu_18850(puuD)
KPN: KPN_01020(puuD)
KPE: KPK_3540(puuD)
KPU: KP1_2005
SPE: Spro_2067(puuD)
DNO: DNO_0653
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:15590624]
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
A novel putrescine utilization pathway involves gamma-glutamylated
intermediates of Escherichia coli K-12.
J. Biol. Chem. 280 (2005) 4602-8.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.1.94
IUBMB Enzyme Nomenclature: 3.5.1.94
ExPASy - ENZYME nomenclature database: 3.5.1.94
BRENDA, the Enzyme Database: 3.5.1.94 |
|---|
