| Entry |
|
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| Name |
succinylglutamate desuccinylase;
N2-succinylglutamate desuccinylase;
SGDS;
AstE |
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
 |
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| Sysname |
N-succinyl-L-glutamate amidohydrolase |
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| Reaction(IUBMB) |
N-succinyl-L-glutamate + H2O = succinate + L-glutamate [RN:R00411] |
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| Reaction(KEGG) |
R00411
 |
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| Substrate |
N-succinyl-L-glutamate [CPD:C05931];
H2O [CPD:C00001] |
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| Product |
succinate [CPD:C00042];
L-glutamate [CPD:C00025] |
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| Comment |
Requires Co2+ for maximal activity [1]. N2-Acetylglutamate is not a
substrate. This is the final enzyme in the arginine
succinyltransferase (AST) pathway for the catabolism of arginine
[1]. This pathway converts the carbon skeleton of arginine into
glutamate, with the concomitant production of ammonia and conversion
of succinyl-CoA into succinate and CoA. The five enzymes involved in
this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC
3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11
(acetylornithine transaminase), EC 1.2.1.71
(succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96
(succinylglutamate desuccinylase). |
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| Pathway |
PATH: ec00330 Arginine and proline metabolism |
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| Orthology |
KO: K05526 succinylglutamate desuccinylase |
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| Genes |
ECO: b1744(astE)
ECJ: JW1733(astE)
ECD: ECDH10B_1882(astE)
EBW: BWG_1557(astE)
ECE: Z2776(ydjS)
ECS: ECs2450
ECF: ECH74115_2462(astE)
ETW: ECSP_2312(astE)
ECG: E2348C_1872(astE)
ECC: c2144(ydjS)
ECI: UTI89_C1939(ydjS)
ECP: ECP_1690
ECV: APECO1_813(ydjS)
ECW: EcE24377A_1966(astE)
ECX: EcHS_A1827(astE)
ECM: EcSMS35_1447(astE)
ECY: ECSE_1914
ECL: EcolC_1888
ECK: EC55989_1912(astE)
ECQ: ECED1_1946(astE)
ECR: ECIAI1_1805(astE)
ECT: ECIAI39_1310(astE)
ECZ: ECS88_1796(astE)
EUM: ECUMN_2033(astE)
ELF: LF82_0184(astE)
EBL: B21_01701(astE)
EBD: ECBD_1901
EBR: ECB_01713(astE)
EOH: ECO103_1937(astE)
EOI: ECO111_2255(astE)
EOJ: ECO26_2519(astE)
EFE: EFER_1321(astE)
STY: STY1807(astE)
STT: t1186(astE)
SPT: SPA1537(astE)
SEK: SSPA1428
SPQ: SPAB_02036
SEI: SPC_2424(astE)
SEC: SC1328(astE)
SEH: SeHA_C1434(astE)
SEE: SNSL254_A1419(astE)
SEW: SeSA_A1402(astE)
SEA: SeAg_B1866(astE)
SED: SeD_A2039(astE)
SEG: SG1809(astE)
SET: SEN1736(astE)
SES: SARI_01672
STM: STM1307(astE)
YPE: YPO1966(astE)
YPK: y2345
YPM: YP_1711
YPA: YPA_1348
YPG: YpAngola_A2516(astE)
YPP: YPDSF_1157
YPS: YPTB1963(astE)
YPI: YpsIP31758_2117(astE)
YPY: YPK_2225
YPB: YPTS_2015
YEN: YE2465(astE)
SFL: SF1482(ydjS)
SFX: S1599(ydjS)
SFV: SFV_1476(ydjS)
SSN: SSON_1413(ydjS)
SBO: SBO_1346(ydjS)
SBC: SbBS512_E1990(astE)
SDY: SDY_1533(ydjS)
ETA: ETA_18550(astE)
PLU: plu3106(astE)
PAY: PAU_01501(astE)
ENT: Ent638_1700
ESA: ESA_02153
CTU: Ctu_18200(astE)
KPN: KPN_01225(astE) KPN_01497
KPE: KPK_2964 KPK_3217(astE)
KPU: KP1_2256(astE) KP1_2504
CKO: CKO_01770
SPE: Spro_2840
DDA: Dd703_0488
VCH: VC1242
VCO: VC0395_A0863(astE)
VCM: VCM66_1197(astE)
VCJ: VCD_003107
VVU: VV1_2783
VVY: VV1479
VPA: VP1310
VHA: VIBHAR_02131
VSP: VS_1697
VEX: VEA_003688
VFI: VF_1238(astE)
VFM: VFMJ11_1321
VSA: VSAL_I1730
PPR: PBPRA2153
PAE: PA0901(aruE)
PAU: PA14_52630(aruE)
PAP: PSPA7_4614(astE)
PAG: PLES_44151(aruE)
PPU: PP_4475(astE)
PPF: Pput_1440
PPG: PputGB1_3980
PPW: PputW619_3764
PST: PSPTO_1838(astE)
PSB: Psyr_3559
PSP: PSPPH_3515(astE)
PFL: PFL_4509(astE)
PFO: Pfl01_4279
PFS: PFLU4751
PMY: Pmen_2905
PSA: PST_1651(astE)
ACI: ACIAD1289(astE)
ACB: A1S_3128
ABM: ABSDF0359(astE)
ABY: ABAYE0356(astE)
ABC: ACICU_03330
ABN: AB57_3583(astE)
ABB: ABBFA_000381(astE)
SON: SO_2338(astE)
SDN: Sden_1785
SFR: Sfri_1934
SAZ: Sama_1708
SBL: Sbal_2223
SBM: Shew185_2148
SBN: Sbal195_2198
SBP: Sbal223_2236
SLO: Shew_1924
SPC: Sputcn32_1884
SSE: Ssed_2330
SPL: Spea_2247
SHE: Shewmr4_2029
SHM: Shewmr7_1946
SHN: Shewana3_2132
SHW: Sputw3181_2124
SHL: Shal_2235
SWD: Swoo_2277
SWP: swp_2607
ILO: IL1681
CPS: CPS_0633(astE)
PHA: PSHAa1633
PAT: Patl_2195
MAQ: Maqu_3311
AMC: MADE_02550
HCH: HCH_05217(astE)
CSA: Csal_2780
MMW: Mmwyl1_1121
AHA: AHA_2868
ASA: ASA_1466(astE)
KKO: Kkor_1422
CVI: CV_2877(astE)
BMA: BMA0596(astE)
BMV: BMASAVP1_A2420(astE)
BML: BMA10229_A2871(astE)
BMN: BMA10247_1731(astE)
BPS: BPSL2385(astE)
BPM: BURPS1710b_2841(astE)
BPL: BURPS1106A_2780(astE)
BPD: BURPS668_2722(astE)
BPR: GBP346_A2902(astE)
BTE: BTH_I1780
BVI: Bcep1808_1104
BUR: Bcep18194_A4296
BCN: Bcen_0706
BCH: Bcen2424_1185
BCM: Bcenmc03_1162
BCJ: BCAL1064(astE)
BAM: Bamb_1066
BAC: BamMC406_1066
BMU: Bmul_2119
BMJ: BMULJ_01125(astE)
BXE: Bxe_A2918
BPH: Bphy_1782
BPY: Bphyt_1563
BGL: bglu_1g10150
GFO: GFO_1742
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:2865249]
Vander Wauven C, Stalon V.
Occurrence of succinyl derivatives in the catabolism of arginine in
Pseudomonas cepacia.
J. Bacteriol. 164 (1985) 882-6.
Pseudomonas cepacia |
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Reference
Authors
Title
Journal
|
2 [PMID:3534538]
Cunin R, Glansdorff N, Pierard A, Stalon V.
Biosynthesis and metabolism of arginine in bacteria.
Microbiol. Rev. 50 (1986) 314-52. |
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Reference
Authors
Title
Journal
|
3
Cunin, R., Glansdorff, N., Pierard, A. and Stalon, V.
Erratum report: Biosynthesis and metabolism of arginine in bacteria.
Microbiol. Rev. 51 (1987) 178. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:9393691]
Itoh Y.
Cloning and characterization of the aru genes encoding enzymes of
the catabolic arginine succinyltransferase pathway in Pseudomonas
aeruginosa.
J. Bacteriol. 179 (1997) 7280-90.
Pseudomonas aeruginosa |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:9696779]
Schneider BL, Kiupakis AK, Reitzer LJ.
Arginine catabolism and the arginine succinyltransferase pathway in
Escherichia coli.
J. Bacteriol. 180 (1998) 4278-86.
Escherichia coli [GN:eco] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.1.96
IUBMB Enzyme Nomenclature: 3.5.1.96
ExPASy - ENZYME nomenclature database: 3.5.1.96
BRENDA, the Enzyme Database: 3.5.1.96
CAS: 99676-40-1 |
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