KEGG   ENZYME: 3.5.2.14Help
Entry
EC 3.5.2.14                 Enzyme                                 
Name N-methylhydantoinase (ATP-hydrolysing);
N-methylhydantoin amidohydrolase;
methylhydantoin amidase;
N-methylhydantoin hydrolase;
N-methylhydantoinase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
BRITE hierarchy
Sysname N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)
Reaction(IUBMB) ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate +
N-carbamoylsarcosine [RN:R03187]
Reaction(KEGG) R03187
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Substrate ATP [CPD:C00002];
N-methylimidazolidine-2,4-dione [CPD:C02565];
H2O [CPD:C00001]
Product ADP [CPD:C00008];
phosphate [CPD:C00009];
N-carbamoylsarcosine [CPD:C01043]
Pathway PATH: ec00330  Arginine and proline metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01473  N-methylhydantoinase A
KO: K01474  N-methylhydantoinase B
Genes PPU: PP_3514(hyuB) PP_3515(hyuA)
PPF: Pput_2260 Pput_2261
PPG: PputGB1_2413 PputGB1_2414
PFL: PFL_2732 PFL_2733
AVN: Avin_20910(acxA)
PAR: Psyc_1449
PCR: Pcryo_1375
SWD: Swoo_4027 Swoo_4028
AEH: Mlg_1104 Mlg_2644
TGR: Tgr7_0321 Tgr7_2462
ABO: ABO_0720(hyuB) ABO_2584(hyuA)
REU: Reut_B5473 Reut_B5474 Reut_C6223 Reut_C6263 Reut_C6264
BUR: Bcep18194_B1206 Bcep18194_B3096 Bcep18194_B3097
BXE: Bxe_A1473 Bxe_A1474 Bxe_B0371 Bxe_B0372 Bxe_B1105 Bxe_B2496
     Bxe_B2497 Bxe_C0790 Bxe_C0791 Bxe_C1059 Bxe_C1060
BPH: Bphy_6150
BPY: Bphyt_6535 Bphyt_6536
BPE: BP0753(hyuA) BP0754(hyuB) BP0821(hyuB) BP0822(hyuA)
BPA: BPP0316(hyuB) BPP3170 BPP3171 BPP3408(hyuA)
BBR: BB0318(hyuA) BB0319(hyuB) BB3571 BB3572 BB3858(hyuA)
     BB3859(hyuB)
BPT: Bpet1112(hyuA)
BAV: BAV0953(hyuB) BAV0954(hyuA) BAV3293(hyuB) BAV3294(hyuA)
PNA: Pnap_1163
VEI: Veis_1519 Veis_1520 Veis_1831 Veis_1833 Veis_1912 Veis_1913
DAC: Daci_5631 Daci_5632
VAP: Vapar_0802 Vapar_0803 Vapar_5965 Vapar_5966
EBA: ebA2051(hyuA) ebA2053(hyuB)
HPY: HP0695
HPJ: jhp0633
HPA: HPAG1_0680
HPS: HPSH_03375
HAC: Hac_0951(hyuA)
GUR: Gura_4360
PCA: Pcar_3103(hyuA) Pcar_3104(hyuB)
DMA: DMR_28190(hyuB) DMR_28210(hyuA)
DSA: Desal_3219 Desal_3220
DRT: Dret_0560 Dret_0561
BBA: Bd1059(hyuB) Bd1060(hyuA)
SCL: sce2621(huyB) sce2622(huyA1)
MLO: mlr4786 mlr4788 mlr7024 mlr7025 mlr9030 mlr9031
MES: Meso_2646 Meso_2647 Meso_3731 Meso_3732
PLA: Plav_1151
SMD: Smed_3306 Smed_3307 Smed_3663 Smed_3664
ATU: Atu6022(hyuA) Atu6023(hyuB)
ATC: AGR_pTi_62(hyuA) AGR_pTi_63(hyuB)
ARA: Arad_14157 Arad_14159 Arad_7521 Arad_7522 Arad_8102 Arad_8103
     Arad_8279 Arad_8280
AVI: Avi_5833(hyuB) Avi_5834(hyuA) Avi_7017(hyuB) Avi_8176(hyuA)
     Avi_8319(hyuB) Avi_8320(hyuA) Avi_9128(hyuA) Avi_9129(hyuB)
     Avi_9148(hyuA) Avi_9149(hyuB)
REC: RHECIAT_PC0000617(hyuB) RHECIAT_PC0000618(hyuA)
     RHECIAT_PC0000815 RHECIAT_PC0000816
RLE: pRL120411(hyuA) pRL120412(hyuB)
RLT: Rleg2_6260 Rleg2_6261 Rleg2_6272 Rleg2_6273
RHI: NGR_b03090 NGR_b03100 NGR_c34400 NGR_c34410
OAN: Oant_4581 Oant_4582
BJA: bll7179 bll7180 blr3326 blr3327 blr3621 blr3622
BRA: BRADO3229 BRADO3230 BRADO5506(hyuA) BRADO5507(hyuB)
BBT: BBta_4925 BBta_4926 BBta_5988(hyuA) BBta_5989(hyuB)
RPB: RPB_4428 RPB_4429
RPD: RPD_2367 RPD_2368
RPE: RPE_3216 RPE_3217
XAU: Xaut_1341
AZC: AZC_1796 AZC_1797 AZC_2116 AZC_2117 AZC_2354 AZC_2355 AZC_3039
     AZC_3040
MET: M446_1934 M446_1935 M446_1980 M446_1981 M446_4696 M446_4697
     M446_5647 M446_5648
MNO: Mnod_1245 Mnod_1246 Mnod_3115 Mnod_3116 Mnod_3415 Mnod_3416
     Mnod_8487 Mnod_8488
PZU: PHZ_c2370 PHZ_c2371 PHZ_c2436 PHZ_c2437
SIL: SPO1472(hyuA) SPO1473 SPO1695 SPO1696
RSP: RSP_0639 RSP_0640
RSH: Rsph17029_2292 Rsph17029_2293
RSK: RSKD131_1995 RSKD131_1996
JAN: Jann_3764 Jann_3765 Jann_3811 Jann_3812
RDE: RD1_3584(hyuA) RD1_3585
PDE: Pden_0472 Pden_4352 Pden_4353 Pden_4408 Pden_4409 Pden_4973
     Pden_4974
DSH: Dshi_0691(hyuA) Dshi_0692(hyuB)
HBA: Hbal_1501 Hbal_1502
NAR: Saro_0175 Saro_0176
SWI: Swit_0475 Swit_0476 Swit_1718 Swit_1719 Swit_2035 Swit_2036
     Swit_2083 Swit_3075 Swit_3649 Swit_4143 Swit_4144 Swit_4226
GOX: GOX0216 GOX0217
GDI: GDI_0197 GDI_0198
GDJ: Gdia_2266 Gdia_2267
RCE: RC1_3712(hyuA) RC1_3713(huyB)
BLI: BL00460 BL00462 BL01720 BL01721
BLD: BLi00395 BLi00396 BLi01982 BLi01984
BPU: BPUM_0314 BPUM_0315
GKA: GK2893 GK2894
GWC: GWCH70_0376 GWCH70_0377
GYC: GYMC61_3601 GYMC61_3602
LSP: Bsph_2204 Bsph_2205
CBE: Cbei_3519
CPY: Cphy_3766
DRM: Dred_1559 Dred_1560
DAE: Dtox_4192 Dtox_4193
TEX: Teth514_0422
TPD: Teth39_1813
MTA: Moth_1966 Moth_1967
MSM: MSMEG_3973
MVA: Mvan_4898
MMC: Mmcs_5242 Mmcs_5243
MKM: Mkms_5330
MJL: Mjls_5621 Mjls_5622
CAR: cauri_0637(hyuB) cauri_0638(hyuA)
NFA: nfa21940 nfa21950
RHA: RHA1_ro00479(hyuA) RHA1_ro00480(hyuB) RHA1_ro03486 RHA1_ro03487
     RHA1_ro10160
RER: RER_58720(hyuB) RER_58730
ROP: ROP_32790(hyuB) ROP_32800(hyuA) ROP_34350(hyuB) ROP_34360(hyuA)
GBR: Gbro_2859 Gbro_2860
ART: Arth_3641 Arth_3642
ACH: Achl_0135 Achl_0136
NCA: Noca_0079 Noca_0080 Noca_1496 Noca_1497
SRO: Sros_2528 Sros_2529 Sros_4046 Sros_4047 Sros_6594 Sros_6595
FRA: Francci3_2507
FRE: Franean1_0985 Franean1_4825 Franean1_4826 Franean1_6188
NML: Namu_5341 Namu_5342
SVI: Svir_20940 Svir_20950
AMI: Amir_2849 Amir_2850
CAI: Caci_1876 Caci_1877
RXY: Rxyl_1695 Rxyl_1696 Rxyl_2410 Rxyl_2411
APV: Apar_0161
ABA: Acid345_2039 Acid345_3921
SRU: SRU_0113 SRU_0177
RMR: Rmar_1062 Rmar_1063
MIN: Minf_0590(hyuA) Minf_0593(hyuB)
GAU: GAU_1179(hyuA) GAU_1181(hyuB)
CYA: CYA_1791 CYA_2800
CYB: CYB_0961 CYB_2234
MAR: MAE_08800 MAE_28130
CYT: cce_1670 cce_2075
CYP: PCC8801_1233 PCC8801_1926
CYC: PCC7424_3529 PCC7424_3534
CYH: Cyan8802_1953
GVI: gll1226 gll2098
ANA: all4969 all4970
NPU: Npun_R6521 Npun_R6523
AVA: Ava_2245 Ava_2246
CTS: Ctha_1385
RRS: RoseRS_2091 RoseRS_2092 RoseRS_2708 RoseRS_4325
RCA: Rcas_1777 Rcas_1778 Rcas_1968 Rcas_3492 Rcas_3493 Rcas_4426
CAU: Caur_2263 Caur_2264
CAG: Cagg_3090 Cagg_3091
CHL: Chy400_2436 Chy400_2437
TRO: trd_A0514 trd_A0515
STI: Sthe_0008 Sthe_0009 Sthe_0273 Sthe_0274
AAE: aq_1925(hyuB) aq_708(hyuA)
PMX: PERMA_1470 PERMA_1472
MJA: MJ0963 MJ0964
MKA: MK1048(hyuB) MK1091(hyuA_1)
HMA: pNG7164(hyuA) pNG7165(hyuB)
HWA: HQ2241A(hyuB) HQ2242A(hyuA)
NPH: NP2952A(hyuB_1) NP2954A(hyuA_1) NP6216A(hyuB_2) NP6218A(hyuA_2)
HUT: Huta_2412 Huta_2413
HMU: Hmuk_0037 Hmuk_0038
TVO: TVN0811 TVN0812
PTO: PTO0461 PTO0462
TSI: TSIB_0819 TSIB_0820
APE: APE_1328.1(hyuA) APE_1331(hyuB) APE_2528.1(hyuA)
     APE_2530.1(hyuB)
IHO: Igni_0292
HBU: Hbut_1623 Hbut_1624
SSO: SSO1662(huyB-1) SSO1663(huyA-1) SSO2008(huyA-2) SSO2010(hyuB-2)
     SSO2934(hyuB-3) SSO2936(hyuA-3)
STO: ST1685 ST1686
SAI: Saci_0368(oplA) Saci_0369(oplA) Saci_2041(huyA) Saci_2042
SIS: LS215_0888 LS215_0889 LS215_1100 LS215_1101 LS215_2583
     LS215_2584
SIA: M1425_0554 M1425_0555 M1425_2410 M1425_2411
SIM: M1627_0575 M1627_0576 M1627_2487 M1627_2488
SID: M164_0584 M164_0585 M164_2415 M164_2416
SIY: YG5714_0957 YG5714_0958
SIN: YN1551_1917 YN1551_1918 YN1551_2241 YN1551_2242
MSE: Msed_1127 Msed_1128
PAI: PAE2028 PAE2030
PIS: Pisl_0131 Pisl_0132
PCL: Pcal_0424 Pcal_0425
PAS: Pars_0413 Pars_0414
CMA: Cmaq_1391 Cmaq_1392
TNE: Tneu_0466 Tneu_0467
Taxonomy
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:3827889]
Kim JM, Shimizu S, Yamada H.
Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis.
Biochem. Biophys. Res. Commun. 142 (1987) 1006-12.
Pseudomonas putida
Other DBs ExplorEnz - The Enzyme Database: 3.5.2.14
IUBMB Enzyme Nomenclature: 3.5.2.14
ExPASy - ENZYME nomenclature database: 3.5.2.14
BRENDA, the Enzyme Database: 3.5.2.14
CAS: 100785-00-0
DBGET integrated database retrieval system