| Entry |
|
|---|
| Name |
dihydropyrimidinase;
hydantoinase;
hydropyrimidine hydrase;
hydantoin peptidase;
pyrimidine hydrase;
D-hydantoinase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
 |
|---|
| Sysname |
5,6-dihydropyrimidine amidohydrolase |
|---|
| Reaction(IUBMB) |
5,6-dihydrouracil + H2O = 3-ureidopropanoate [RN:R02269] |
|---|
| Reaction(KEGG) |
R02269;
(other) R03055 R08227
 |
|---|
| Substrate |
5,6-dihydrouracil [CPD:C00429];
H2O [CPD:C00001] |
|---|
| Product |
3-ureidopropanoate [CPD:C02642] |
|---|
| Comment |
Also acts on dihydrothymine and hydantoin. |
|---|
| Pathway |
PATH: ec00240 Pyrimidine metabolism
PATH: ec00410 beta-Alanine metabolism
PATH: ec00770 Pantothenate and CoA biosynthesis
PATH: ec00983 Drug metabolism - other enzymes
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01464 dihydropyrimidinase |
|---|
| Genes |
HSA: 1807(DPYS)
MCC: 695342(DPYS)
MMU: 64705(Dpys)
RNO: 65135(Dpys)
CFA: 475067(DPYS)
BTA: 509241(DPYS)
SSC: 100156500
MDO: 100031051
GGA: 420266(DPYS)
TGU: 100224054
XLA: 495311
DRE: 100144569(dpys)
SPU: 579662
DME: Dmel_CG1411(CRMP)
DPO: Dpse_GA12765
DAN: Dana_GF20697
DER: Dere_GG12914
DPE: Dper_GL22308
DSE: Dsec_GM10816
DSI: Dsim_GD19795
DYA: Dyak_GE10139
DGR: Dgri_GH15883 Dgri_GH20890
DMO: Dmoj_GI20644 Dmoj_GI23638
AGA: AgaP_AGAP003124
AAG: AaeL_AAEL007633
CQU: CpipJ_CPIJ010151
NVI: 100119994
TCA: 662209
API: 100161725
CEL: C47E12.8(dhp-2)
CBR: CBG03443
SMM: Smp_085110.2
NVE: NEMVE_v1g161336
HMG: 100201224
TAD: TRIADDRAFT_63495
ATH: AT5G12200
POP: POPTR_722702
RCU: RCOM_0975020
VVI: 100253111
OSA: 4327558(Os01g0807900)
SBI: SORBI_03g037550(SORBIDRAFT_03g037550)
ZMA: 100272767(pco084866)
PPP: PHYPADRAFT_133247
CRE: CHLREDRAFT_97227
KLA: KLLA0C19107g
ZRO: ZYRO0F12364g
ANI: AN1823.2 AN8418.2
ANG: An08g05950 An13g03910
PCS: Pc22g20690
CNE: CNF01380
CNB: CNBF3330
DDI: DDB_0191172(pyd2)
ECO: b2873(hyuA)
ECJ: JW2841(hyuA)
ECD: ECDH10B_3048(hyuA)
EBW: BWG_2599(hyuA)
ECE: Z4212
ECS: ECs3746
ECF: ECH74115_4163(hyuA)
ETW: ECSP_3843(hyuA)
ECG: E2348C_3125(hyuA)
ECC: c3451(ygeZ)
ECI: UTI89_C3258(ygeZ)
ECP: ECP_2867
ECV: APECO1_3653(ygeZ)
ECW: EcE24377A_3198(hyuA)
ECX: EcHS_A3033(hyuA)
ECM: EcSMS35_3006(hyuA)
ECY: ECSE_3137
ECL: EcolC_0835
ECK: EC55989_3160(hyuA)
ECQ: ECED1_3333(hyuA)
ECR: ECIAI1_2993(hyuA)
ECT: ECIAI39_3288(hyuA)
ECZ: ECS88_3152(hyuA)
EUM: ECUMN_3216(hyuA)
ELF: LF82_1080(hyuA)
EBL: B21_02668(ygeZ)
EBD: ECBD_0864
EBR: ECB_02706(ygeZ)
EOH: ECO103_3448(hyuA)
EOI: ECO111_3611(hyuA)
EOJ: ECO26_3962(hyuA)
SBO: SBO_3111
EIC: NT01EI_3530
ETR: ETAE_3175(ygeZ)
DDA: Dd703_0046
PPR: PBPRA1991
PAE: PA0441(dht)
PAU: PA14_05770(dht)
PAP: PSPA7_0543(hydA)
PAG: PLES_04391(dht)
PPF: Pput_1802
PPG: PputGB1_3638
PPW: PputW619_1836
PFL: PFL_2548(hydA)
PFO: Pfl01_3441
PFS: PFLU3942
PEN: PSEEN3253(dht)
SHL: Shal_0638
CPS: CPS_4055(dht)
AHA: AHA_2164(hydA)
RPI: Rpic_4022
RPF: Rpic12D_4135
REU: Reut_A0045
REH: H16_A0068 H16_A3075
RME: Rmet_3886
CTI: RALTA_A2550(hyuA)
BVI: Bcep1808_5513
BUR: Bcep18194_C6658
BCN: Bcen_1593 Bcen_6385
BCH: Bcen2424_6238 Bcen2424_6618
BCM: Bcenmc03_6216 Bcenmc03_6714
BCJ: BCAS0731(dht)
BAM: Bamb_5963
BAC: BamMC406_5719
BMU: Bmul_5353
BMJ: BMULJ_06145(dpyS)
BXE: Bxe_A1431 Bxe_C0732
BPH: Bphy_1532 Bphy_4992
BPY: Bphyt_2687 Bphyt_4250
BAV: BAV0626 BAV0676
POL: Bpro_0551 Bpro_0686
PNA: Pnap_4021
AAV: Aave_0969
VEI: Veis_0725 Veis_4149
DAC: Daci_2864
VAP: Vapar_4277 Vapar_5601 Vapar_6048
CTT: CtCNB1_2936
SCL: sce6399(dht)
HOH: Hoch_2182
MLO: mll1629
MES: Meso_2664
SME: SMc01821(dht)
SMD: Smed_2367 Smed_2983
ATU: Atu2386(dht)
ATC: AGR_C_4328
ARA: Arad_3447(hydA) Arad_9605(hydA)
AVI: Avi_3457(dht)
RET: RHE_CH03292(dht)
REC: RHECIAT_CH0003535(dht)
RLE: RL3718(dht) RL4487 pRL120126
RLT: Rleg2_3038
RLG: Rleg_3293 Rleg_5687
RHI: NGR_c24840(dht)
BME: BMEI1644
BMS: BR0278(dht)
BMT: BSUIS_A0302(hydA)
BOV: BOV_0292(hydA)
BCS: BCAN_A0282(hydA)
BMR: BMI_I284(dht)
OAN: Oant_0347
BJA: blr3295 blr3333 blr7615(dht)
BRA: BRADO1492 BRADO1792(hyuA) BRADO6163(dht)
BBT: BBta_2108(hyuA) BBta_6029(dht) BBta_6542
AZC: AZC_1966 AZC_2674
MRD: Mrad2831_3941
MET: M446_2543
MNO: Mnod_7926 Mnod_7944
SIL: SPO1783(hydA)
SIT: TM1040_1497
RSP: RSP_0183(dht) RSP_3462
RSH: Rsph17029_1816 Rsph17029_3107
RSQ: Rsph17025_1462 Rsph17025_2067
RSK: RSKD131_1523 RSKD131_3628
JAN: Jann_1488 Jann_2705
RDE: RD1_2404(hydA) RD1_3100(hydA)
PDE: Pden_1112 Pden_4616
DSH: Dshi_1370(dht)
GDI: GDI_2004(dht) GDI_2717(dht)
GDJ: Gdia_0227 Gdia_0931
APT: APA01_21680
BCL: ABC3783
GKA: GK1423
GYC: GYMC61_2214
LSP: Bsph_2008
BBE: BBR47_32360(pydB)
PJD: Pjdr2_4687
EFA: EF2580
CTC: CTC01781
CDF: CD2083 CD3178
CDC: CD196_1947 CD196_2988
CDL: CDR20291_1990 CDR20291_3034
CBO: CBO2886
CBA: CLB_2850(hydA-2)
CBH: CLC_2783(hydA)
CBY: CLM_3282(hydA)
CBL: CLK_2280(hydA)
CBK: CLL_A0634(hydA)
CBB: CLD_1656(hydA)
CBI: CLJ_B3140(hydA)
CBT: CLH_0593(hydA)
CBF: CLI_2942(hydA)
CBE: Cbei_1942 Cbei_1970
CKL: CKL_2401
CKR: CKR_2117
CPY: Cphy_1496
AMT: Amet_4584
AOE: Clos_0362
VPR: Vpar_1266
DSY: DSY1806
DHD: Dhaf_2960
DRM: Dred_0261
HMO: HM1_2642(hydA)
APR: Apre_0357 Apre_1430
MTA: Moth_1997
MSM: MSMEG_3553(hydA) MSMEG_3996(hydA) MSMEG_4012(hydA)
MAB: MAB_2817c
SCO: SCO6415(SC1A6.04)
SMA: SAV_1949(dht)
SGR: SGR_1231
ART: Arth_4066
BCV: Bcav_2578
NCA: Noca_1635
SRO: Sros_6635
FRE: Franean1_5731
FAL: FRAAL1416(pydB)
KRA: Krad_4267
SEN: SACE_3419(pydB)
AMI: Amir_2099
RXY: Rxyl_0219 Rxyl_0358 Rxyl_2746
APV: Apar_0244
BHY: BHWA1_00074
SUS: Acid_7659
CPI: Cpin_3445
STR: Sterm_1684
MIN: Minf_0625(pyrC)
TAI: Taci_0430
STI: Sthe_1390
TME: Tmel_0119
TAF: THA_349
PMO: Pmob_1730
KOL: Kole_2072
MMA: MM_0750 MM_2253
HLA: Hlac_1099 Hlac_3269
DKA: DKAM_0625
NMR: Nmar_0214
 |
|---|
| Structures |
PDB: 1GKP 1GKQ 1GKR 1NFG 1YNY 2FTW 2FTY 2FVK 2FVM 2GSE
2VR2 3DC8 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6639068]
Brooks KP, Jones EA, Kim BD, Sander EG.
Bovine liver dihydropyrimidine amidohydrolase: purification,
properties, and characterization as a zinc metalloenzyme.
Arch. Biochem. Biophys. 226 (1983) 469-83.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:15393763]
EADIE GS, BERNHEIM F, BERNHEIM ML.
The partial purification and properties of animal and plant
hydantoinases.
J. Biol. Chem. 181 (1949) 449-58.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.2.2
IUBMB Enzyme Nomenclature: 3.5.2.2
ExPASy - ENZYME nomenclature database: 3.5.2.2
BRENDA, the Enzyme Database: 3.5.2.2
CAS: 9030-74-4 |
|---|
