KEGG   ENZYME: 3.5.2.6Help
Entry
EC 3.5.2.6                  Enzyme                                 

Name beta-lactamase;
penicillinase;
cephalosporinase;
neutrapen;
penicillin beta-lactamase;
exopenicillinase;
ampicillinase;
penicillin amido-beta-lactamhydrolase;
penicillinase I, II;
beta-lactamase I-III;
beta-lactamase A, B, C;
beta-lactamase AME I;
cephalosporin-beta-lactamase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
BRITE hierarchy
Sysname beta-lactam hydrolase
Reaction(IUBMB) a beta-lactam + H2O = a substituted beta-amino acid [RN:R03743]
Reaction(KEGG) R03743 > R04318 R06363
Show
Substrate beta-lactam [CPD:C01866];
H2O [CPD:C00001]
Product substituted beta-amino acid [CPD:C03806]
Inhibitor m-Carboxyphenyl phenylacetamidomethylphosphonate [CPD:C04684]
Comment A group of enzymes of varying specificity hydrolysing beta-lactams;
some act more rapidly on penicillins, some more rapidly on
cephalosporins. The latter were formerly listed as EC 3.5.2.8,
cephalosporinase.
Pathway PATH: ec00311  Penicillin and cephalosporin biosynthesis
PATH: ec00312  beta-Lactam resistance
Orthology KO: K01467  beta-lactamase
Genes PIC: PICST_88817(BDE99)
TET: TTHERM_00170490
ECO: b4150(ampC)
ECJ: JW4111(ampC)
ECD: ECDH10B_4345(ampC)
EBW: BWG_3865(ampC)
ECE: Z5757(ampC)
ECS: ECs5131(ampC)
ECF: ECH74115_5668(ampC)
ETW: ECSP_5252(ampC)
ECC: c5238(ampC)
ECI: UTI89_C4750(ampC)
ECP: ECP_4396(ampC)
ECV: APECO1_2239(ampC)
ECW: EcE24377A_4709(ampC)
ECX: EcHS_A4394(ampC)
ECY: ECSE_4452(ampC)
ECL: EcolC_3860(ampC)
ECK: EC55989_4707(ampC)
ECR: ECIAI1_4387(ampC)
EBL: B21_03984(ampC)
EBD: ECBD_3879
EBR: ECB_04022(ampC)
STY: HCM1.216(bla)
SEC: SC018(tem-1) SC090(ampC)
YEN: YE2019(blaA) YE2440(ampC)
SFL: SF4308(ampC)
SFX: S4573(ampC)
SFV: SFV_4309(ampC)
SSN: SSON_4336(ampC)
SBO: SBO_4306(ampC)
SBC: SbBS512_E4682(ampC)
SDY: SDY_4394(ampC)
ETA: ETA_05080(ampC)
PLU: plu0831(ampC)
PAY: PAU_00771(ampC)
ENT: Ent638_0339(ampC)
ESA: ESA_01875
KPN: KPN_01607 KPN_pKPN4p07062
KPE: KPK_2780
KPU: KP1_2635(blaSHV-11)
CKO: CKO_01737
SPE: Spro_2273 Spro_3259
HIT: NTHI2055
XFA: XF1621
XFT: PD1157(pbp)
XCC: XCC2636 XCC2873(bla) XCC3039(bla)
XCB: XC_1119 XC_1235 XC_1481
XCA: xccb100_1156 xccb100_1281(ampC1)
XCV: XCV2113(ampC1) XCV2967(ampC2) XCV3193(ampC3) XCV3293(penP)
XAC: XAC2806 XAC3057(bla) XAC3162(bla)
XOO: XOO1370(bla) XOO1556 XOO1797(bla)
XOM: XOO_1261 XOO_1444 XOO_1700
SML: Smlt3652 Smlt3722
VVU: VV1_0001
VPA: VPA0477
VFI: VF_1099
PPR: PBPRB0809
PAE: PA4110(ampC) PA5514(poxB)
PAU: PA14_10790(ampC) PA14_72760
PAP: PSPA7_0984(ampC) PSPA7_6316
PAG: PLES_08611(ampC)
PPU: PP_2876(ampC)
PPF: Pput_2813(ampC)
PST: PSPTO_3594(ampC)
PSB: Psyr_3364(ampC)
PSP: PSPPH_3284(ampC)
PFL: PFL_4054(ampC)
PFO: Pfl01_3723(ampC)
PEN: PSEEN3018(ampC)
PMY: Pmen_2038(ampC)
PSA: PST_0928 PST_2699
CJA: CJA_3110
PCR: Pcryo_1775(ampC)
ACI: ACIAD3597(ampC)
ACB: A1S_1517 A1S_2367(ampC)
ABM: ABSDF2125(bla-OXA-75)
ABY: ABAYE1110(ampC) ABAYE2122(bla-OXA-69) ABAYE3619(oxa-10)
     ABAYE3623(veb-1)
SON: SO_0837 SO_2388(ampC)
SDN: Sden_0675 Sden_0822 Sden_3154
SFR: Sfri_0887
SAZ: Sama_1178
SBL: Sbal_2086(ampC) Sbal_3522
SBM: Shew185_0813 Shew185_2266(ampC)
SBN: Sbal195_0845 Sbal195_2383(ampC)
SBP: Sbal223_2079(ampC)
SLO: Shew_1968 Shew_3220
SPC: Sputcn32_2029(ampC) Sputcn32_3157
SSE: Ssed_2498 Ssed_3414
SHE: Shewmr4_0694 Shewmr4_1937(ampC)
SHM: Shewmr7_2039(ampC) Shewmr7_3328
SHN: Shewana3_1990(ampC) Shewana3_3440
SHW: Sputw3181_0786 Sputw3181_1984(ampC)
CPS: CPS_0483
PAT: Patl_4159
MAQ: Maqu_1080
PIN: Ping_1621
LPN: lpg1618 lpg2412(ampC)
LPF: lpl1405 lpl2336(ampC)
LPP: lpp1588 lpp2481(ampC)
LPC: LPC_1045 LPC_2062(ampC)
MCA: MCA2220
FTU: FTT_0611c FTT_0681c(blaA)
FTF: FTF0611c FTF0681c(blaA)
FTW: FTW_1047(blaA) FTW_1117
FTL: FTL_0879 FTL_0957
FTH: FTH_0865(bla) FTH_0935(penP)
FTN: FTN_1002(blaA) FTN_1072
HCH: HCH_02299(penP)
CSA: Csal_0193(ampC)
AHA: AHA_0740 AHA_3135(ampC) AHA_4258
ASA: ASA_1191(ampC) ASA_3612(cphA5) ASA_4346(ampS)
CVI: CV_1310(ampC) CV_3150
RSO: RS02005(RSp0030) RSc0258
RPI: Rpic_0111 Rpic_3817 Rpic_3962
RPF: Rpic12D_0118 Rpic12D_3930 Rpic12D_4075
REU: Reut_A0157 Reut_A1684
REH: H16_A1195 H16_A2128(bla1) H16_B0553(bla2) H16_B0871
     H16_B1301(ampC) H16_B1495 H16_B1574(ampC2)
RME: Rmet_0121 Rmet_1776(ampC) Rmet_4436
CTI: RALTA_B1200(ampC)
BMA: BMAA1283(penA)
BMV: BMASAVP1_0257(blaA)
BML: BMA10229_0527(blaA)
BMN: BMA10247_A1040(blaA)
BPS: BPSS0946(penA) BPSS1997(oxa)
BPM: BURPS1710b_A1106(oxa) BURPS1710b_A2553
BPL: BURPS1106A_A1301(blaA) BURPS1106A_A2719(oxa)
BPD: BURPS668_A1381(blaA) BURPS668_A2872
BTE: BTH_II0373(oxa) BTH_II1450
BVI: Bcep1808_4738 Bcep1808_5125 Bcep1808_5453
BUR: Bcep18194_B0510 Bcep18194_B0762 Bcep18194_B1245 Bcep18194_B1711
     Bcep18194_B2849 Bcep18194_C6892 Bcep18194_C7532(ampC)
BCN: Bcen_3438 Bcen_3769 Bcen_4788 Bcen_5713(ampC)
BCH: Bcen2424_3379 Bcen2424_4599 Bcen2424_4929 Bcen2424_6077(ampC)
BCM: Bcenmc03_5358 Bcenmc03_6561(ampC)
BCJ: BCAM2165(penA) BCAS0156(ampC)
BAM: Bamb_4029 Bamb_4360 Bamb_6103(ampC)
BAC: BamMC406_4877 BamMC406_5864(ampC)
BMU: Bmul_6008(ampC)
BMJ: BMULJ_05519(ampC)
BXE: Bxe_B1593(ampC)
BPH: Bphy_1164
BPY: Bphyt_5057(ampC)
BPA: BPP2606
BBR: BB2049
BPT: Bpet3865(ampC)
RFR: Rfer_3580
POL: Bpro_4226
PNA: Pnap_0431
AAV: Aave_0182 Aave_0183 Aave_2552 Aave_4202
AJS: Ajs_0515 Ajs_2328
VEI: Veis_2059
DIA: Dtpsy_0531
HAR: HEAR0606(blaA) HEAR1185
NET: Neut_1060
EBA: ebA3647
AZO: azo0398 azo3682
DAR: Daro_0083
MFA: Mfla_2477
APP: CAP2UW1_4322
TDN: Suden_0951
CJE: Cj0299
CJR: CJE0344
CFF: CFF8240_0828
GUR: Gura_3505
GLO: Glov_2580
PPD: Ppro_0184
BBA: Bd3212
ADE: Adeh_0354
MXA: MXAN_5519
SAT: SYN_01571
RFE: RF_1275(blaD)
RBE: RBE_0107(blaD)
MES: Meso_2215
PLA: Plav_3016
SME: SM_b21600(ampC) SMc00047(bla) SMc02026
SMD: Smed_0594 Smed_4921(ampC)
ATU: Atu3077(ampC) Atu3376
ATC: AGR_L_2891 AGR_L_3464(ampC)
ARA: Arad_3372(ampC)
RET: RHE_CH01220(bla) RHE_CH03194(ampC)
REC: RHECIAT_CH0003435(ampC)
RLE: RL1352 RL3159(ampC) pRL110477
RLT: Rleg2_2947(ampC)
RLG: Rleg_2695
RHI: NGR_c07370 NGR_c32650
OAN: Oant_2585(ampC)
BJA: bll0941(bla) bll5360 blr5292(ampC) blr6230 blr7890
BRA: BRADO2167 BRADO2248 BRADO4063 BRADO4627(oxa5) BRADO6967
BBT: BBta_0565 BBta_2483 BBta_4439 BBta_5028(oxa5)
RPA: RPA0362(penP)
RPB: RPB_2340
RPC: RPC_2728 RPC_3398
RPD: RPD_3124
RPE: RPE_0911 RPE_1865 RPE_3542
RPT: Rpal_0366
NWI: Nwi_0351
NHA: Nham_0446
AZC: AZC_4278
MEX: Mext_1480(ampC)
MEA: Mex_1p1373(ampC)
MDI: METDI2143(ampC)
MRD: Mrad2831_4082
MPO: Mpop_1481(ampC)
MCH: Mchl_1758(ampC)
SIL: SPO2592
SIT: TM1040_0211
RSP: RSP_3749(ampC)
PDE: Pden_3450(ampC)
MMR: Mmar10_0370
HNE: HNE_0411 HNE_2763
ZMO: ZMO1967
NAR: Saro_0280
SAL: Sala_0174
GBE: GbCGDNIH1_0107 GbCGDNIH1_1173
GDI: GDI_1971(bla)
GDJ: Gdia_0195
RRU: Rru_A0228
MGM: Mmc1_0424
BSU: BSU02090(ybxI) BSU18800(penP)
BAN: BA2507(bla1) BA3500(bla2)
BAR: GBAA2507(bla1) GBAA3500(bla2)
BAA: BA_2997
BAT: BAS2328 BAS3245
BAH: BAMEG_2095(bla1)
BAI: BAA_2563(bla1)
BCE: BC2473 BC3440
BCA: BCE_2539 BCE_3452(bla2)
BCZ: BCZK0412(pbpX) BCZK2247(bla) BCZK2916(pbp) BCZK3155(bla)
     BCZK3161 BCZK3208(bla) BCZK3890 pE33L466_0098(pbp)
BCR: BCAH187_A2595(bla1)
BCB: BCB4264_A2503
BCU: BCAH820_2522(bla1)
BCG: BCG9842_B2020 BCG9842_B2820(bla1)
BCQ: BCQ_2417(bla)
BCX: BCA_2591(bla1)
BTK: BT9727_2291(bla) BT9727_3218(bla)
BTL: BALH_0439(pbpX) BALH_2254 BALH_3094(bla)
BWE: BcerKBAB4_2331 BcerKBAB4_2421
BLI: BL01642(blaP)
BLD: BLi00280(penP)
BCL: ABC0264(penP) ABC3481
BAY: RBAM_012080(penP)
OIH: OB0667 OB2793 OB3072
SAU: SAP010(blaZ)
SAR: SAR1831(blaZ)
SAS: pSAS19(blaZ)
SAA: SAUSA300_0959(fmt)
SAJ: SaurJH9_2749
SAH: SaurJH1_2827
SEP: SE1608
SER: SEA0003(blaZ-2) SERP1461(blaZ-1)
SHA: SH1764(blaZ)
SSP: SSP2186
LIN: lin0199
LWE: lwe0137
BBE: BBR47_12040(penP)
LLC: LACR_0015
LLM: llmg_0018
SPZ: M5005_Spy_0010
SPH: MGAS10270_Spy0010
SPI: MGAS10750_Spy0010
SPJ: MGAS2096_Spy0010
SPK: MGAS9429_Spy0010
SPF: SpyM50010
SPA: M6_Spy0010
SPB: M28_Spy0010
STC: str0009
STL: stu0009
STE: STER_0011
SSA: SSA_0012
SSU: SSU05_0012
SSV: SSU98_0015
LPL: lp_0469(bla1) lp_2341(bla2)
LAC: LBA1639
LBR: LVIS_2002
LCA: LSEI_2771
LGA: LGAS_1856
CAC: CAC0190
CPE: CPE1184
CPF: CPF_1388
CPR: CPR_1202
CKL: CKL_2902(bla)
STH: STH915
MTU: Rv2068c(blaC)
MTC: MT2128(bla)
MRA: MRA_2082(blaC)
MBO: Mb2094c(blaC)
MBB: BCG_2087c(blaC)
MAV: MAV_1030
MSM: MSMEG_2658 MSMEG_3978(ampC) MSMEG_6194
MUL: MUL_2294(blaC)
MVA: Mvan_2352
MGI: Mflv_4021
MAB: MAB_2875
MMC: Mmcs_2102
MKM: Mkms_2148
MJL: Mjls_2085
MMI: MMAR_1674(ampC)
NFA: nfa23080
RHA: RHA1_ro00175 RHA1_ro00177 RHA1_ro01701 RHA1_ro02713
     RHA1_ro03541
SCO: SCO3774(SCH63.21)
SMA: SAV_4452(blaA3)
LXX: Lxx01020
CMI: CMM_2676(blaC)
RSA: RSal33209_0207 RSal33209_0210(blaB)
KRA: Krad_1931
SEN: SACE_1373 SACE_1374(penA) SACE_3056 SACE_3877 SACE_4081
     SACE_4283(penP) SACE_5313(ampC2)
AMI: Amir_3962
STP: Strop_1457 Strop_1458
SAQ: Sare_1418 Sare_1419
RXY: Rxyl_1288
LIL: LA1549
LIC: LIC12220(blaR1)
ABA: Acid345_1607 Acid345_1709 Acid345_3247 Acid345_4151
SUS: Acid_2285 Acid_6874
BTH: BT_4507
BFR: BF1250
BFS: BF1199(cepA)
CHU: CHU_1887 CHU_3232(ampC)
FJO: Fjoh_0467 Fjoh_3485
FNU: FN1584
AMU: Amuc_0183
SYN: slr0121 slr0319(blaOXA-3)
SYW: SYNW0718
SYC: syc0060_d(ampC)
SYF: Synpcc7942_1603
SYD: Syncc9605_1950
SYE: Syncc9902_0715
SYG: sync_0964
SYR: SynRCC307_0731
SYX: SynWH7803_1598
SYP: SYNPCC7002_A1262
CYA: CYA_0811
CYB: CYB_1894
TEL: tll2115
ANA: all2480 all4822 alr4543
AVA: Ava_0412 Ava_1408 Ava_2092
PMA: Pro1145(penP)
PMT: PMT1133
PMN: PMN2A_0697
PMF: P9303_08971(penP)
PME: NATL1_15311(penP)
TER: Tery_3876
CPH: Cpha266_1596
RRS: RoseRS_3511
RCA: Rcas_0624
DRA: DR_0433
DGE: Dgeo_0316
PTO: PTO0760 PTO1203
PAB: PAB0087(pbp)
HBU: Hbut_1035
Taxonomy
Structures PDB: 1A7T  1A8T  1ALQ  1AXB  1BC2  1BLC  1BLH  1BLP  1BLS  1BMC  
     1BSG  1BT5  1BTL  1BUE  1BUL  1BVT  1BZA  1C3B  1CK3  1DD6  
     1DDK  1DJA  1DJB  1DJC  1DXK  1DY6  1E25  1E3U  1E4D  1ERM  
     1ERO  1ERQ  1ESU  1EWZ  1FCM  1FCN  1FCO  1FOF  1FQG  1FR1  
     1FR6  1FSW  1FSY  1G68  1G6A  1GA0  1GA9  1GCE  1GHI  1GHM  
     1GHP  1H5X  1H8Y  1H8Z  1HLK  1HTZ  1HZO  1I2S  1I2W  1I5Q  
     1IEL  1IEM  1IYO  1IYP  1IYQ  1IYS  1JJE  1JJT  1JT1  1JTD  
     1JTG  1JVJ  1JWP  1JWV  1JWZ  1K07  1K38  1K4E  1K4F  1K54  
     1K55  1K56  1K57  1K6R  1K6S  1KDS  1KDW  1KE0  1KE3  1KE4  
     1KGE  1KGF  1KGG  1KO2  1KO3  1KR3  1KVL  1KVM  1L0D  1L0E  
     1L0F  1L0G  1L2S  1L9Y  1LHY  1LI0  1LI9  1LL5  1LL9  1LLB  
     1M2X  1M40  1M6K  1MBL  1MQO  1MXO  1MY8  1N4O  1N9B  1NXY  
     1NY0  1NYM  1NYY  1O07  1O7E  1OME  1ONG  1ONH  1PI4  1PI5  
     1PIO  1PZO  1PZP  1Q2P  1Q2Q  1RCJ  1RGY  1RGZ  1S6R  1SHV  
     1SML  1TDG  1TDL  1TEM  1VGN  1VM1  1W7F  1WE4  1WUO  1WUP  
     1X8G  1X8H  1X8I  1XGI  1XGJ  1XPB  1XX2  1XXM  1Y54  1YLJ  
     1YLP  1YLT  1YLW  1YLY  1YLZ  1YM1  1YMS  1YMX  1YT4  1ZC2  
     1ZG4  1ZG6  1ZKJ  1ZNB  2A3U  2A49  2AIO  2B5R  2BC2  2BFK  
     2BFL  2BFZ  2BG2  2BG6  2BG7  2BG8  2BGA  2BLM  2BLS  2BMI  
     2CC1  2DOO  2FFY  2FHX  2FM6  2FU6  2FU7  2FU8  2FU9  2G2U  
     2G2W  2GDN  2GFJ  2GFK  2GKL  2GMN  2H0T  2H0Y  2H10  2H5S  
     2H6A  2HB9  2HDQ  2HDR  2HDS  2HDU  2HP5  2HP6  2HP9  2HPB  
     2I72  2JC7  2NXA  2NYP  2NZE  2NZF  2OV5  2P74  2P9V  2PU2  
     2PU4  2Q9M  2Q9N  2QDS  2QDT  2QIN  2QJS  2QMI  2QZ6  2R9W  
     2R9X  2RCX  2RL3  2UYX  2V1Z  2V20  2WGI  2WK0  2WYX  2WZX  
     2WZZ  2YZ3  2ZC7  2ZD8  2ZJ9  2ZNB  2ZQ7  2ZQ8  2ZQ9  2ZQA  
     2ZQC  2ZQD  3B3X  3BC2  3BEB  3BEC  3BFC  3BFD  3BFE  3BFF  
     3BFG  3BLM  3BLS  3BM6  3BYD  3C4O  3C4P  3C7U  3C7V  3CG5  
     3CMZ  3D4F  3DTM  3DWZ  3E2K  3E2L  3F9O  3FAI  3FCZ  3FKV  
     3FKW  3G2Y  3G2Z  3G30  3G31  3G32  3G34  3G35  3GQZ  3GR2  
     3GRJ  3GSG  3GTC  3GV9  3GVB  3HBR  3I0V  3I11  3I13  3I14  
     3I15  3ISG  3JYI  3ZNB  4BLM  4ZNB  
Reference
  Authors
  Title
  Journal

1
Citri, N.
Penicillinase and other beta-lactamases.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 4, Academic Press,
New York, 1971, p. 23-46.
Reference
  Authors
  Title

  Journal
  Organism
2  [PMID:5685878]
Hennessey TD, Richmond MH.
The purification and some properties of a beta-lactamase
(cephalosporinase) synthesized by Enterobactercloacae.
Biochem. J. 109 (1968) 469-73.
Enterobacter cloacae
Reference
  Authors
  Title

  Journal
  Organism
3  [PMID:4990588]
Kuwabara S.
Purification and properties of two extracellular beta-lactamases
from Bacillus cereus 569-H.
Biochem. J. 118 (1970) 457-65.
Bacillus cereus
Reference
  Authors
  Title
  Journal

4
Pollock, M.R.
Penicillinase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 269-278.
Reference
  Authors
  Title
  Journal
  Organism
5  [PMID:13303985]
POLLOCK MR, TORRIANI AM, TRIDGELL EJ.
Crystalline bacterial penicillinase.
Biochem. J. 62 (1956) 387-91.
Escherichia coli [GN:eco], Bacillus cereus
Reference
  Authors
  Title
  Journal
  Organism
6  [PMID:4731970]
Ross GW, Boulton MG.
Purification of beta-lactamases on QAE-sephadex.
Biochim. Biophys. Acta. 309 (1973) 430-9.
Klebsiella aerogenes
Other DBs ExplorEnz - The Enzyme Database: 3.5.2.6
IUBMB Enzyme Nomenclature: 3.5.2.6
ExPASy - ENZYME nomenclature database: 3.5.2.6
BRENDA, the Enzyme Database: 3.5.2.6
CAS: 9073-60-3

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