| Entry |
|
|---|
| Name |
beta-lactamase;
penicillinase;
cephalosporinase;
neutrapen;
penicillin beta-lactamase;
exopenicillinase;
ampicillinase;
penicillin amido-beta-lactamhydrolase;
penicillinase I, II;
beta-lactamase I-III;
beta-lactamase A, B, C;
beta-lactamase AME I;
cephalosporin-beta-lactamase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
 |
|---|
| Sysname |
beta-lactam hydrolase |
|---|
| Reaction(IUBMB) |
a beta-lactam + H2O = a substituted beta-amino acid [RN:R03743] |
|---|
| Reaction(KEGG) |
R03743 > R04318 R06363
 |
|---|
| Substrate |
beta-lactam [CPD:C01866];
H2O [CPD:C00001] |
|---|
| Product |
substituted beta-amino acid [CPD:C03806] |
|---|
| Inhibitor |
m-Carboxyphenyl phenylacetamidomethylphosphonate [CPD:C04684] |
|---|
| Comment |
A group of enzymes of varying specificity hydrolysing beta-lactams;
some act more rapidly on penicillins, some more rapidly on
cephalosporins. The latter were formerly listed as EC 3.5.2.8,
cephalosporinase. |
|---|
| Pathway |
PATH: ec00311 Penicillin and cephalosporin biosynthesis
PATH: ec00312 beta-Lactam resistance |
|---|
| Orthology |
KO: K01467 beta-lactamase |
|---|
| Genes |
PIC: PICST_88817(BDE99)
TET: TTHERM_00170490
ECO: b4150(ampC)
ECJ: JW4111(ampC)
ECD: ECDH10B_4345(ampC)
EBW: BWG_3865(ampC)
ECE: Z5757(ampC)
ECS: ECs5131(ampC)
ECF: ECH74115_5668(ampC)
ETW: ECSP_5252(ampC)
ECC: c5238(ampC)
ECI: UTI89_C4750(ampC)
ECP: ECP_4396(ampC)
ECV: APECO1_2239(ampC)
ECW: EcE24377A_4709(ampC)
ECX: EcHS_A4394(ampC)
ECY: ECSE_4452(ampC)
ECL: EcolC_3860(ampC)
ECK: EC55989_4707(ampC)
ECR: ECIAI1_4387(ampC)
EBL: B21_03984(ampC)
EBD: ECBD_3879
EBR: ECB_04022(ampC)
STY: HCM1.216(bla)
SEC: SC018(tem-1) SC090(ampC)
YEN: YE2019(blaA) YE2440(ampC)
SFL: SF4308(ampC)
SFX: S4573(ampC)
SFV: SFV_4309(ampC)
SSN: SSON_4336(ampC)
SBO: SBO_4306(ampC)
SBC: SbBS512_E4682(ampC)
SDY: SDY_4394(ampC)
ETA: ETA_05080(ampC)
PLU: plu0831(ampC)
PAY: PAU_00771(ampC)
ENT: Ent638_0339(ampC)
ESA: ESA_01875
KPN: KPN_01607 KPN_pKPN4p07062
KPE: KPK_2780
KPU: KP1_2635(blaSHV-11)
CKO: CKO_01737
SPE: Spro_2273 Spro_3259
HIT: NTHI2055
XFA: XF1621
XFT: PD1157(pbp)
XCC: XCC2636 XCC2873(bla) XCC3039(bla)
XCB: XC_1119 XC_1235 XC_1481
XCA: xccb100_1156 xccb100_1281(ampC1)
XCV: XCV2113(ampC1) XCV2967(ampC2) XCV3193(ampC3) XCV3293(penP)
XAC: XAC2806 XAC3057(bla) XAC3162(bla)
XOO: XOO1370(bla) XOO1556 XOO1797(bla)
XOM: XOO_1261 XOO_1444 XOO_1700
SML: Smlt3652 Smlt3722
VVU: VV1_0001
VPA: VPA0477
VFI: VF_1099
PPR: PBPRB0809
PAE: PA4110(ampC) PA5514(poxB)
PAU: PA14_10790(ampC) PA14_72760
PAP: PSPA7_0984(ampC) PSPA7_6316
PAG: PLES_08611(ampC)
PPU: PP_2876(ampC)
PPF: Pput_2813(ampC)
PST: PSPTO_3594(ampC)
PSB: Psyr_3364(ampC)
PSP: PSPPH_3284(ampC)
PFL: PFL_4054(ampC)
PFO: Pfl01_3723(ampC)
PEN: PSEEN3018(ampC)
PMY: Pmen_2038(ampC)
PSA: PST_0928 PST_2699
CJA: CJA_3110
PCR: Pcryo_1775(ampC)
ACI: ACIAD3597(ampC)
ACB: A1S_1517 A1S_2367(ampC)
ABM: ABSDF2125(bla-OXA-75)
ABY: ABAYE1110(ampC) ABAYE2122(bla-OXA-69) ABAYE3619(oxa-10)
ABAYE3623(veb-1)
SON: SO_0837 SO_2388(ampC)
SDN: Sden_0675 Sden_0822 Sden_3154
SFR: Sfri_0887
SAZ: Sama_1178
SBL: Sbal_2086(ampC) Sbal_3522
SBM: Shew185_0813 Shew185_2266(ampC)
SBN: Sbal195_0845 Sbal195_2383(ampC)
SBP: Sbal223_2079(ampC)
SLO: Shew_1968 Shew_3220
SPC: Sputcn32_2029(ampC) Sputcn32_3157
SSE: Ssed_2498 Ssed_3414
SHE: Shewmr4_0694 Shewmr4_1937(ampC)
SHM: Shewmr7_2039(ampC) Shewmr7_3328
SHN: Shewana3_1990(ampC) Shewana3_3440
SHW: Sputw3181_0786 Sputw3181_1984(ampC)
CPS: CPS_0483
PAT: Patl_4159
MAQ: Maqu_1080
PIN: Ping_1621
LPN: lpg1618 lpg2412(ampC)
LPF: lpl1405 lpl2336(ampC)
LPP: lpp1588 lpp2481(ampC)
LPC: LPC_1045 LPC_2062(ampC)
MCA: MCA2220
FTU: FTT_0611c FTT_0681c(blaA)
FTF: FTF0611c FTF0681c(blaA)
FTW: FTW_1047(blaA) FTW_1117
FTL: FTL_0879 FTL_0957
FTH: FTH_0865(bla) FTH_0935(penP)
FTN: FTN_1002(blaA) FTN_1072
HCH: HCH_02299(penP)
CSA: Csal_0193(ampC)
AHA: AHA_0740 AHA_3135(ampC) AHA_4258
ASA: ASA_1191(ampC) ASA_3612(cphA5) ASA_4346(ampS)
CVI: CV_1310(ampC) CV_3150
RSO: RS02005(RSp0030) RSc0258
RPI: Rpic_0111 Rpic_3817 Rpic_3962
RPF: Rpic12D_0118 Rpic12D_3930 Rpic12D_4075
REU: Reut_A0157 Reut_A1684
REH: H16_A1195 H16_A2128(bla1) H16_B0553(bla2) H16_B0871
H16_B1301(ampC) H16_B1495 H16_B1574(ampC2)
RME: Rmet_0121 Rmet_1776(ampC) Rmet_4436
CTI: RALTA_B1200(ampC)
BMA: BMAA1283(penA)
BMV: BMASAVP1_0257(blaA)
BML: BMA10229_0527(blaA)
BMN: BMA10247_A1040(blaA)
BPS: BPSS0946(penA) BPSS1997(oxa)
BPM: BURPS1710b_A1106(oxa) BURPS1710b_A2553
BPL: BURPS1106A_A1301(blaA) BURPS1106A_A2719(oxa)
BPD: BURPS668_A1381(blaA) BURPS668_A2872
BTE: BTH_II0373(oxa) BTH_II1450
BVI: Bcep1808_4738 Bcep1808_5125 Bcep1808_5453
BUR: Bcep18194_B0510 Bcep18194_B0762 Bcep18194_B1245 Bcep18194_B1711
Bcep18194_B2849 Bcep18194_C6892 Bcep18194_C7532(ampC)
BCN: Bcen_3438 Bcen_3769 Bcen_4788 Bcen_5713(ampC)
BCH: Bcen2424_3379 Bcen2424_4599 Bcen2424_4929 Bcen2424_6077(ampC)
BCM: Bcenmc03_5358 Bcenmc03_6561(ampC)
BCJ: BCAM2165(penA) BCAS0156(ampC)
BAM: Bamb_4029 Bamb_4360 Bamb_6103(ampC)
BAC: BamMC406_4877 BamMC406_5864(ampC)
BMU: Bmul_6008(ampC)
BMJ: BMULJ_05519(ampC)
BXE: Bxe_B1593(ampC)
BPH: Bphy_1164
BPY: Bphyt_5057(ampC)
BPA: BPP2606
BBR: BB2049
BPT: Bpet3865(ampC)
RFR: Rfer_3580
POL: Bpro_4226
PNA: Pnap_0431
AAV: Aave_0182 Aave_0183 Aave_2552 Aave_4202
AJS: Ajs_0515 Ajs_2328
VEI: Veis_2059
DIA: Dtpsy_0531
HAR: HEAR0606(blaA) HEAR1185
NET: Neut_1060
EBA: ebA3647
AZO: azo0398 azo3682
DAR: Daro_0083
MFA: Mfla_2477
APP: CAP2UW1_4322
TDN: Suden_0951
CJE: Cj0299
CJR: CJE0344
CFF: CFF8240_0828
GUR: Gura_3505
GLO: Glov_2580
PPD: Ppro_0184
BBA: Bd3212
ADE: Adeh_0354
MXA: MXAN_5519
SAT: SYN_01571
RFE: RF_1275(blaD)
RBE: RBE_0107(blaD)
MES: Meso_2215
PLA: Plav_3016
SME: SM_b21600(ampC) SMc00047(bla) SMc02026
SMD: Smed_0594 Smed_4921(ampC)
ATU: Atu3077(ampC) Atu3376
ATC: AGR_L_2891 AGR_L_3464(ampC)
ARA: Arad_3372(ampC)
RET: RHE_CH01220(bla) RHE_CH03194(ampC)
REC: RHECIAT_CH0003435(ampC)
RLE: RL1352 RL3159(ampC) pRL110477
RLT: Rleg2_2947(ampC)
RLG: Rleg_2695
RHI: NGR_c07370 NGR_c32650
OAN: Oant_2585(ampC)
BJA: bll0941(bla) bll5360 blr5292(ampC) blr6230 blr7890
BRA: BRADO2167 BRADO2248 BRADO4063 BRADO4627(oxa5) BRADO6967
BBT: BBta_0565 BBta_2483 BBta_4439 BBta_5028(oxa5)
RPA: RPA0362(penP)
RPB: RPB_2340
RPC: RPC_2728 RPC_3398
RPD: RPD_3124
RPE: RPE_0911 RPE_1865 RPE_3542
RPT: Rpal_0366
NWI: Nwi_0351
NHA: Nham_0446
AZC: AZC_4278
MEX: Mext_1480(ampC)
MEA: Mex_1p1373(ampC)
MDI: METDI2143(ampC)
MRD: Mrad2831_4082
MPO: Mpop_1481(ampC)
MCH: Mchl_1758(ampC)
SIL: SPO2592
SIT: TM1040_0211
RSP: RSP_3749(ampC)
PDE: Pden_3450(ampC)
MMR: Mmar10_0370
HNE: HNE_0411 HNE_2763
ZMO: ZMO1967
NAR: Saro_0280
SAL: Sala_0174
GBE: GbCGDNIH1_0107 GbCGDNIH1_1173
GDI: GDI_1971(bla)
GDJ: Gdia_0195
RRU: Rru_A0228
MGM: Mmc1_0424
BSU: BSU02090(ybxI) BSU18800(penP)
BAN: BA2507(bla1) BA3500(bla2)
BAR: GBAA2507(bla1) GBAA3500(bla2)
BAA: BA_2997
BAT: BAS2328 BAS3245
BAH: BAMEG_2095(bla1)
BAI: BAA_2563(bla1)
BCE: BC2473 BC3440
BCA: BCE_2539 BCE_3452(bla2)
BCZ: BCZK0412(pbpX) BCZK2247(bla) BCZK2916(pbp) BCZK3155(bla)
BCZK3161 BCZK3208(bla) BCZK3890 pE33L466_0098(pbp)
BCR: BCAH187_A2595(bla1)
BCB: BCB4264_A2503
BCU: BCAH820_2522(bla1)
BCG: BCG9842_B2020 BCG9842_B2820(bla1)
BCQ: BCQ_2417(bla)
BCX: BCA_2591(bla1)
BTK: BT9727_2291(bla) BT9727_3218(bla)
BTL: BALH_0439(pbpX) BALH_2254 BALH_3094(bla)
BWE: BcerKBAB4_2331 BcerKBAB4_2421
BLI: BL01642(blaP)
BLD: BLi00280(penP)
BCL: ABC0264(penP) ABC3481
BAY: RBAM_012080(penP)
OIH: OB0667 OB2793 OB3072
SAU: SAP010(blaZ)
SAR: SAR1831(blaZ)
SAS: pSAS19(blaZ)
SAA: SAUSA300_0959(fmt)
SAJ: SaurJH9_2749
SAH: SaurJH1_2827
SEP: SE1608
SER: SEA0003(blaZ-2) SERP1461(blaZ-1)
SHA: SH1764(blaZ)
SSP: SSP2186
LIN: lin0199
LWE: lwe0137
BBE: BBR47_12040(penP)
LLC: LACR_0015
LLM: llmg_0018
SPZ: M5005_Spy_0010
SPH: MGAS10270_Spy0010
SPI: MGAS10750_Spy0010
SPJ: MGAS2096_Spy0010
SPK: MGAS9429_Spy0010
SPF: SpyM50010
SPA: M6_Spy0010
SPB: M28_Spy0010
STC: str0009
STL: stu0009
STE: STER_0011
SSA: SSA_0012
SSU: SSU05_0012
SSV: SSU98_0015
LPL: lp_0469(bla1) lp_2341(bla2)
LAC: LBA1639
LBR: LVIS_2002
LCA: LSEI_2771
LGA: LGAS_1856
CAC: CAC0190
CPE: CPE1184
CPF: CPF_1388
CPR: CPR_1202
CKL: CKL_2902(bla)
STH: STH915
MTU: Rv2068c(blaC)
MTC: MT2128(bla)
MRA: MRA_2082(blaC)
MBO: Mb2094c(blaC)
MBB: BCG_2087c(blaC)
MAV: MAV_1030
MSM: MSMEG_2658 MSMEG_3978(ampC) MSMEG_6194
MUL: MUL_2294(blaC)
MVA: Mvan_2352
MGI: Mflv_4021
MAB: MAB_2875
MMC: Mmcs_2102
MKM: Mkms_2148
MJL: Mjls_2085
MMI: MMAR_1674(ampC)
NFA: nfa23080
RHA: RHA1_ro00175 RHA1_ro00177 RHA1_ro01701 RHA1_ro02713
RHA1_ro03541
SCO: SCO3774(SCH63.21)
SMA: SAV_4452(blaA3)
LXX: Lxx01020
CMI: CMM_2676(blaC)
RSA: RSal33209_0207 RSal33209_0210(blaB)
KRA: Krad_1931
SEN: SACE_1373 SACE_1374(penA) SACE_3056 SACE_3877 SACE_4081
SACE_4283(penP) SACE_5313(ampC2)
AMI: Amir_3962
STP: Strop_1457 Strop_1458
SAQ: Sare_1418 Sare_1419
RXY: Rxyl_1288
LIL: LA1549
LIC: LIC12220(blaR1)
ABA: Acid345_1607 Acid345_1709 Acid345_3247 Acid345_4151
SUS: Acid_2285 Acid_6874
BTH: BT_4507
BFR: BF1250
BFS: BF1199(cepA)
CHU: CHU_1887 CHU_3232(ampC)
FJO: Fjoh_0467 Fjoh_3485
FNU: FN1584
AMU: Amuc_0183
SYN: slr0121 slr0319(blaOXA-3)
SYW: SYNW0718
SYC: syc0060_d(ampC)
SYF: Synpcc7942_1603
SYD: Syncc9605_1950
SYE: Syncc9902_0715
SYG: sync_0964
SYR: SynRCC307_0731
SYX: SynWH7803_1598
SYP: SYNPCC7002_A1262
CYA: CYA_0811
CYB: CYB_1894
TEL: tll2115
ANA: all2480 all4822 alr4543
AVA: Ava_0412 Ava_1408 Ava_2092
PMA: Pro1145(penP)
PMT: PMT1133
PMN: PMN2A_0697
PMF: P9303_08971(penP)
PME: NATL1_15311(penP)
TER: Tery_3876
CPH: Cpha266_1596
RRS: RoseRS_3511
RCA: Rcas_0624
DRA: DR_0433
DGE: Dgeo_0316
PTO: PTO0760 PTO1203
PAB: PAB0087(pbp)
HBU: Hbut_1035
 |
|---|
| Structures |
PDB: 1A7T 1A8T 1ALQ 1AXB 1BC2 1BLC 1BLH 1BLP 1BLS 1BMC
1BSG 1BT5 1BTL 1BUE 1BUL 1BVT 1BZA 1C3B 1CK3 1DD6
1DDK 1DJA 1DJB 1DJC 1DXK 1DY6 1E25 1E3U 1E4D 1ERM
1ERO 1ERQ 1ESU 1EWZ 1FCM 1FCN 1FCO 1FOF 1FQG 1FR1
1FR6 1FSW 1FSY 1G68 1G6A 1GA0 1GA9 1GCE 1GHI 1GHM
1GHP 1H5X 1H8Y 1H8Z 1HLK 1HTZ 1HZO 1I2S 1I2W 1I5Q
1IEL 1IEM 1IYO 1IYP 1IYQ 1IYS 1JJE 1JJT 1JT1 1JTD
1JTG 1JVJ 1JWP 1JWV 1JWZ 1K07 1K38 1K4E 1K4F 1K54
1K55 1K56 1K57 1K6R 1K6S 1KDS 1KDW 1KE0 1KE3 1KE4
1KGE 1KGF 1KGG 1KO2 1KO3 1KR3 1KVL 1KVM 1L0D 1L0E
1L0F 1L0G 1L2S 1L9Y 1LHY 1LI0 1LI9 1LL5 1LL9 1LLB
1M2X 1M40 1M6K 1MBL 1MQO 1MXO 1MY8 1N4O 1N9B 1NXY
1NY0 1NYM 1NYY 1O07 1O7E 1OME 1ONG 1ONH 1PI4 1PI5
1PIO 1PZO 1PZP 1Q2P 1Q2Q 1RCJ 1RGY 1RGZ 1S6R 1SHV
1SML 1TDG 1TDL 1TEM 1VGN 1VM1 1W7F 1WE4 1WUO 1WUP
1X8G 1X8H 1X8I 1XGI 1XGJ 1XPB 1XX2 1XXM 1Y54 1YLJ
1YLP 1YLT 1YLW 1YLY 1YLZ 1YM1 1YMS 1YMX 1YT4 1ZC2
1ZG4 1ZG6 1ZKJ 1ZNB 2A3U 2A49 2AIO 2B5R 2BC2 2BFK
2BFL 2BFZ 2BG2 2BG6 2BG7 2BG8 2BGA 2BLM 2BLS 2BMI
2CC1 2DOO 2FFY 2FHX 2FM6 2FU6 2FU7 2FU8 2FU9 2G2U
2G2W 2GDN 2GFJ 2GFK 2GKL 2GMN 2H0T 2H0Y 2H10 2H5S
2H6A 2HB9 2HDQ 2HDR 2HDS 2HDU 2HP5 2HP6 2HP9 2HPB
2I72 2JC7 2NXA 2NYP 2NZE 2NZF 2OV5 2P74 2P9V 2PU2
2PU4 2Q9M 2Q9N 2QDS 2QDT 2QIN 2QJS 2QMI 2QZ6 2R9W
2R9X 2RCX 2RL3 2UYX 2V1Z 2V20 2WGI 2WK0 2WYX 2WZX
2WZZ 2YZ3 2ZC7 2ZD8 2ZJ9 2ZNB 2ZQ7 2ZQ8 2ZQ9 2ZQA
2ZQC 2ZQD 3B3X 3BC2 3BEB 3BEC 3BFC 3BFD 3BFE 3BFF
3BFG 3BLM 3BLS 3BM6 3BYD 3C4O 3C4P 3C7U 3C7V 3CG5
3CMZ 3D4F 3DTM 3DWZ 3E2K 3E2L 3F9O 3FAI 3FCZ 3FKV
3FKW 3G2Y 3G2Z 3G30 3G31 3G32 3G34 3G35 3GQZ 3GR2
3GRJ 3GSG 3GTC 3GV9 3GVB 3HBR 3I0V 3I11 3I13 3I14
3I15 3ISG 3JYI 3ZNB 4BLM 4ZNB |
|---|
Reference
Authors
Title
Journal
|
1
Citri, N.
Penicillinase and other beta-lactamases.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 4, Academic Press,
New York, 1971, p. 23-46. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5685878]
Hennessey TD, Richmond MH.
The purification and some properties of a beta-lactamase
(cephalosporinase) synthesized by Enterobactercloacae.
Biochem. J. 109 (1968) 469-73.
Enterobacter cloacae |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4990588]
Kuwabara S.
Purification and properties of two extracellular beta-lactamases
from Bacillus cereus 569-H.
Biochem. J. 118 (1970) 457-65.
Bacillus cereus |
|---|
Reference
Authors
Title
Journal
|
4
Pollock, M.R.
Penicillinase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 269-278. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:13303985]
POLLOCK MR, TORRIANI AM, TRIDGELL EJ.
Crystalline bacterial penicillinase.
Biochem. J. 62 (1956) 387-91.
Escherichia coli [GN:eco], Bacillus cereus |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:4731970]
Ross GW, Boulton MG.
Purification of beta-lactamases on QAE-sephadex.
Biochim. Biophys. Acta. 309 (1973) 430-9.
Klebsiella aerogenes |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.2.6
IUBMB Enzyme Nomenclature: 3.5.2.6
ExPASy - ENZYME nomenclature database: 3.5.2.6
BRENDA, the Enzyme Database: 3.5.2.6
CAS: 9073-60-3 |
|---|
