| Entry |
|
|---|
| Name |
arginase;
arginine amidinase;
canavanase;
L-arginase;
arginine transamidinase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
 |
|---|
| Sysname |
L-arginine amidinohydrolase |
|---|
| Reaction(IUBMB) |
L-arginine + H2O = L-ornithine + urea [RN:R00551] |
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| Reaction(KEGG) |
R00551
 |
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| Substrate |
L-arginine [CPD:C00062];
H2O [CPD:C00001] |
|---|
| Product |
L-ornithine [CPD:C00077];
urea [CPD:C00086] |
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| Comment |
Also hydrolyses alpha-N-substituted L-arginines and canavanine. |
|---|
| Pathway |
PATH: ec00330 Arginine and proline metabolism
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01476 arginase |
|---|
| Genes |
HSA: 383(ARG1) 384(ARG2)
PTR: 452985(ARG2)
MCC: 711033(ARG2)
MMU: 11846(Arg1) 11847(Arg2)
RNO: 29215(Arg2) 29221(Arg1)
CFA: 474823(ARG1) 480364(ARG2)
BTA: 513608(ARG1) 518752(ARG2)
SSC: 100155893 397115(ARG1)
ECB: 100034051(ARG2) 100073086
MDO: 100023225 100031015
OAA: 100073732
TGU: 100223899
XLA: 379198(arg2) 380109(arg1) 397788
XTR: 448358(arg1) 780142(arg2)
DRE: 100148378 322614(arg2) 570368
BFO: BRAFLDRAFT_279693
CIN: 100181764
SPU: 586250 752410
DME: Dmel_CG18104(arg)
DPO: Dpse_GA14794
DAN: Dana_GF21939
DER: Dere_GG12792
DPE: Dper_GL20388
DSE: Dsec_GM19073
DSI: Dsim_GD16510
DYA: Dyak_GE16619
DGR: Dgri_GH12104
DMO: Dmoj_GI15160
AGA: AgaP_AGAP008783
AAG: AaeL_AAEL002675
CQU: CpipJ_CPIJ015718
AME: 552556
TCA: 655366
ISC: IscW_ISCW012689
SMM: Smp_059980
NVE: NEMVE_v1g224716 NEMVE_v1g241846
HMG: 100201764 100205405
TAD: TRIADDRAFT_52723
ATH: AT4G08900
POP: POPTR_552033
OSA: 4334912(Os04g0106300)
SCE: YPL111W(CAR1)
AGO: AGOS_AGR225C
KLA: KLLA0F00704g
LTH: KLTH0D09372g
DHA: DEHA0G26147g
PIC: PICST_78364(CAR1)
PPA: PAS_chr2-2_0288 PAS_chr4_0684
VPO: Kpol_1048p27
LEL: LELG_04059
ZRO: ZYRO0F10604g
CAL: CaO19.3934(CAR1)
CTP: CTRG_06030
CDU: CD36_54130
CGR: CAGL0J07062g
YLI: YALI0E07535g
SPO: SPAC3H1.07 SPBP26C9.02c(car1)
NCR: NCU02333
PAN: PODANSg2700
MGR: MGG_10854
FGR: FG10967.1
ANI: AN2901.2 AN3965.2
AFM: AFUA_3G11430
AOR: AO090003000697 AO090011000557
ANG: An02g07250(argA) An14g01190
AFV: AFLA_031200 AFLA_043800
PCS: Pc13g09710
NFI: NFIA_065870
CIM: CIMG_03683
URE: UREG_07442
SSL: SS1G_11277
BFU: BC1G_05379
CNE: CNG00550
CNB: CNBG4230
LBC: LACBIDRAFT_176615
MPR: MPER_06441
UMA: UM04939.1
MGL: MGL_2111
MBR: MONBRDRAFT_37086
EHI: EHI_152330
EDI: EDI_168450
PFA: PFI0320w
PFD: PFDG_04401
PFH: PFHG_00119
PYO: PY03443
PBE: PB000787.03.0
PKN: PKH_070380
PVX: PVX_098770
PTM: GSPATT00018241001
TBR: Tb927.8.2020
LMA: LmjF35.1480
LIF: LinJ35.1640
LBZ: LbrM34_V2.1400
TVA: TVAG_025140 TVAG_126050
PTI: PHATRDRAFT_38509
TPS: THAPS_35561
ETA: ETA_27520(rocF)
PAY: PAU_00371(rocF)
KPN: KPN_01054
KPE: KPK_3503
XFA: XF1250
XFT: PD0517(rocF)
XFM: Xfasm12_0585
XFN: XfasM23_0540
XCC: XCC3926(argI)
XCB: XC_4015
XCA: xccb100_4113
XCV: XCV4102(argI)
XAC: XAC4009(argI)
XOO: XOO0435(argI)
XOM: XOO_0397
XOP: PXO_02850(rocF)
SML: Smlt0341(arcA)
SMT: Smal_0238
PSB: Psyr_2212
PFS: PFLU3261
PEN: PSEEN2606
PCR: Pcryo_1794
FPH: Fphi_1231
NOC: Noc_1712
RSO: RSc0158
RPI: Rpic_0051
RPF: Rpic12D_0048
REU: Reut_B4054
RME: Rmet_3926
BAM: Bamb_0213
BAC: BamMC406_0221
BPE: BP0538
BPA: BPP0749
BBR: BB0835
BPT: Bpet2335
RFR: Rfer_3884
POL: Bpro_4603
PNA: Pnap_3772
AAV: Aave_0120
AJS: Ajs_0247
VEI: Veis_0965
DAC: Daci_0681
DIA: Dtpsy_0241
VAP: Vapar_2768 Vapar_4803
CTT: CtCNB1_4178
MPT: Mpe_A1081
LCH: Lcho_2098
DAR: Daro_2468
TBD: Tbd_0069
HPY: HP1399
HPJ: jhp1427(rocF)
HPA: HPAG1_1470
HPS: HPSH_07915
HPG: HPG27_1460(rocF)
HPP: HPP12_1513(rocF)
HPB: HELPY_1512(rocF)
HHE: HH1048(rocF)
HAC: Hac_1761(rocF)
GBM: Gbem_1886
GEO: Geob_1013
GEM: GM21_2324
DSA: Desal_0633
DAT: HRM2_28890(argA1)
HOH: Hoch_5460
MLO: mll6778 mlr5015
MES: Meso_3963
SME: SMa1711(argI2) SMc03091(argI1)
SMD: Smed_2891 Smed_5245
ATU: Atu4007(arcA) Atu6018(arc)
ATC: AGR_L_1693 AGR_pTi_56(arc)
ARA: Arad_12253 Arad_14153(rocF) Arad_4276(rocF)
AVI: Avi_5977(rocF)
RET: RHE_CH03851(argI)
REC: RHECIAT_CH0004132(argI)
RLE: RL4384(arcA)
RLT: Rleg2_3629
RLG: Rleg_3917
RHI: NGR_c30820(arcA1)
BME: BMEII0396
BMI: BMEA_B0881(rocF)
BMF: BAB2_0337(rocF)
BMB: BruAb2_0333(rocF)
BMC: BAbS19_II03190
BMS: BRA0900(rocF)
BMT: BSUIS_B0893(rocF)
BOV: BOV_A0843(rocF)
BCS: BCAN_B0919(rocF)
BMR: BMI_II894(rocF)
OAN: Oant_1470
BJA: bll6122
BRA: BRADO5323
BBT: BBta_5811
RPA: RPA4729(rocF)
RPB: RPB_0842
RPC: RPC_2929
RPD: RPD_0950
RPE: RPE_2678
RPT: Rpal_5210
NWI: Nwi_0352
NHA: Nham_0447
MEX: Mext_0544
MEA: Mex_1p0363(rocF)
MDI: METDI0516(rocF)
MRD: Mrad2831_2470
MET: M446_1825
MPO: Mpop_0515
MCH: Mchl_0203 Mchl_0479
MNO: Mnod_1215
BID: Bind_2813
SIL: SPO2119(rocF)
SIT: TM1040_1165
RSP: RSP_2632(argI)
RSH: Rsph17029_1289
RSQ: Rsph17025_1168
RSK: RSKD131_0943
RDE: RD1_1416(arcA)
PDE: Pden_2047
DSH: Dshi_2309
ZMO: ZMO0432
ZMN: Za10_0815
SWI: Swit_1051
BSU: BSU40320(argI)
BHA: BH0654 BH2984(rocF) BH3948
BAN: BA0154(rocF)
BAR: GBAA0154(rocF)
BAA: BA_0735
BAT: BAS0155
BAH: BAMEG_0184(rocF)
BAI: BAA_0184(rocF)
BCE: BC0185
BCA: BCE_0154(rocF)
BCZ: BCZK0147(rocF)
BCR: BCAH187_A0198(rocF)
BCB: BCB4264_A0186(rocF)
BCU: BCAH820_0177(rocF)
BCG: BCG9842_B5138(rocF)
BCQ: BCQ_0179(rocF)
BCX: BCA_0196(rocF)
BCY: Bcer98_0147
BTK: BT9727_0149(rocF)
BTL: BALH_0151(rocF)
BWE: BcerKBAB4_0148
BLI: BL01739(rocF) BL02695 BL02698
BLD: BLi00198 BLi00424(rocF) BLi00584
BCL: ABC1426
BAY: RBAM_037230(rocF)
BPU: BPUM_0159(rocF)
GKA: GK0149
GTN: GTNG_0145
GWC: GWCH70_0153
GYM: GYMC10_1998 GYMC10_3530
GYC: GYMC61_0149
AFL: Aflv_0146(rocF)
SAU: SA1968(arg)
SAV: SAV2164(arg)
SAW: SAHV_2148(arg)
SAM: MW2091(arg)
SAR: SAR2255(rocF)
SAS: SAS2066
SAC: SACOL2154(rocF)
SAB: SAB2044c(rocF)
SAA: SAUSA300_2114(rocF)
SAX: USA300HOU_2154(arg)
SAO: SAOUHSC_02409
SAJ: SaurJH9_2196
SAH: SaurJH1_2234
SAE: NWMN_2065
SAD: SAAV_2218(rocF)
SSP: SSP0126 SSP0721
LSP: Bsph_1853 Bsph_4571
ESI: Exig_0135
EAT: EAT1b_1596
MCL: MCCL_0318
BBE: BBR47_02630(rocF)
PJD: Pjdr2_3901
AAC: Aaci_0321
LAC: LBA1022 LBA1572
CAC: CAC1054
CTC: CTC01763
AMT: Amet_4424
AOE: Clos_0227
STH: STH2660
DSY: DSY0747
DHD: Dhaf_0755
NTH: Nther_0236
CKP: ckrop_0009(rocF)
SMA: SAV_1895(argI)
SGR: SGR_1149
LXX: Lxx06520(arg1)
CMI: CMM_1134
CMS: CMS_1455
RSA: RSal33209_3378
TFU: Tfu_1543
SEN: SACE_4760(rocF)
SVI: Svir_09260
STP: Strop_3606
SAQ: Sare_3987
CAI: Caci_8299
RXY: Rxyl_1270
BHY: BHWA1_01957(rocF)
ABA: Acid345_4596
ACA: ACP_2205(rocF)
SUS: Acid_2800
PDI: BDI_1757 BDI_2672
CHU: CHU_3637(rocF)
CPI: Cpin_1296 Cpin_6292
PHE: Phep_2319
FJO: Fjoh_4687
FNU: FN0501
GAU: GAU_3904(rocF)
RRS: RoseRS_4137
RCA: Rcas_1461
CAU: Caur_2939
CAG: Cagg_0907
CHL: Chy400_3178
HAU: Haur_1230
STI: Sthe_2293
DRA: DR_0651
DGE: Dgeo_0292
DDR: Deide_02960(rocF)
TTH: TTC1132
TTJ: TTHA1496
MPD: MCP_2587(rocF)
HMA: rrnAC0383(arg2) rrnAC0453(arg1)
HLA: Hlac_0934
HMU: Hmuk_2733
PTO: PTO0716
RCI: LRC523(argI-1) RCIX2268(argI-2)
 |
|---|
| Structures |
PDB: 1CEV 1D3V 1HQ5 1HQF 1HQG 1HQH 1HQX 1P8M 1P8N 1P8O
1P8P 1P8Q 1P8R 1P8S 1PQ3 1R1O 1RLA 1T4P 1T4R 1T4S
1T4T 1T5F 1T5G 1TA1 1TBH 1TBJ 1TBL 1WVA 1WVB 1ZPE
1ZPG 2AEB 2CEV 2EF4 2EF5 2PHA 2PHO 2PLL 2RLA 2ZAV
3CEV 3DJ8 3E6K 3E6V 3E8Q 3E8Z 3E9B 3F80 3GMZ 3KV2
3RLA 4CEV 4RLA 5CEV 5RLA |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13685626]
BACH SJ, KILLIP JD.
Studies on the purification and the kinetic properties of arginase
from beef, sheep and horse liver.
Biochim. Biophys. Acta. 47 (1961) 336-43.
Bos taurus [GN:bta], Equus caballus [GN:ecb], Ovis aries |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13689647]
CABELLO J, BASILIO C, PRAJOUX V.
Kinetic properties of erythrocyte- and liver arginase.
Biochim. Biophys. Acta. 48 (1961) 148-52.
Homo sapiens [GN:hsa], Equus caballus [GN:ecb] |
|---|
Reference
Authors
Title
Journal
|
3 [PMID:4801830]
Dumitru IF.
Study of L-arginine amidinohydrolase from vegetable origin.
Purification, crystallization and molecular weight.
Acta. Vitaminol. Enzymol. 27 (1973) 207-10. |
|---|
Reference
Authors
Title
Journal
|
4
Greenberg, D.M.
Arginase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 257-267. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:13328133]
GREENBERG DM, BAGOT AE, ROHOLT OA Jr.
Liver arginase. III. Properties of highly purified arginase.
Arch. Biochem. Biophys. 62 (1956) 446-53.
Rattus norvegicus [GN:rno], Equus caballus [GN:ecb] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.3.1
IUBMB Enzyme Nomenclature: 3.5.3.1
ExPASy - ENZYME nomenclature database: 3.5.3.1
BRENDA, the Enzyme Database: 3.5.3.1
CAS: 9000-96-8 |
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