| Entry |
|
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| Name |
adenine deaminase;
adenase;
adenine aminase;
ADase |
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
 |
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| Sysname |
adenine aminohydrolase |
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| Reaction(IUBMB) |
adenine + H2O = hypoxanthine + NH3 [RN:R01244] |
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| Reaction(KEGG) |
R01244;
(other) R06137
 |
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| Substrate |
adenine [CPD:C00147];
H2O [CPD:C00001] |
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| Product |
hypoxanthine [CPD:C00262];
NH3 [CPD:C00014] |
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| Pathway |
PATH: ec00230 Purine metabolism
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01486 adenine deaminase |
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| Genes |
ECO: b3665(ade)
ECJ: JW3640(ade)
ECD: ECDH10B_3848(ade)
EBW: BWG_3356(ade)
ECE: Z5155(yicP)
ECS: ECs4602
ECF: ECH74115_5095(ade)
ETW: ECSP_4714(ade)
ECC: c4589(yicP)
ECI: UTI89_C4221(yicP)
ECP: ECP_3871
ECV: APECO1_2787(ade)
ECW: EcE24377A_4173(ade)
ECX: EcHS_A3878(ade)
ECM: EcSMS35_4030(ade)
ECY: ECSE_3949
ECL: EcolC_0034
ECK: EC55989_4133(ade)
ECQ: ECED1_4360(ade)
ECR: ECIAI1_3841(ade)
ECT: ECIAI39_4265(ade)
ECZ: ECS88_4090(ade)
EUM: ECUMN_4192(ade)
ELF: LF82_0034(ade)
EBL: B21_03491(ade)
EBD: ECBD_0038
EBR: ECB_03549(ade)
EOH: ECO103_4492(ade)
EOJ: ECO26_4918(ade)
EFE: EFER_3962(ade)
SFL: SF3796(yicP)
SFX: S3972(yicP)
SFV: SFV_3844(yicP)
SSN: SSON_3619(yicP)
SBO: SBO_3704(yicP)
SBC: SbBS512_E4254(ade)
SDY: SDY_4146(yicP)
KPN: KPN_02554(ade)
KPE: KPK_1614
KPU: KP1_3777(ade)
SPE: Spro_1116
EIC: NT01EI_3924
ETR: ETAE_3544(adeC)
DDA: Dd703_1360
SHL: Shal_2836
BUR: Bcep18194_B1471
SUN: SUN_0856(ade)
GME: Gmet_2201
DVU: DVU0441(ade)
DVL: Dvul_2495
DDE: Dde_0136
DMA: DMR_21960(ade)
DSA: Desal_0516
DBA: Dbac_1063
BBA: Bd2636(yicP)
DPS: DP1373 DP1374
DAL: Dalk_3756
DAT: HRM2_24620(adeC)
SAT: SYN_02726
SFU: Sfum_0417
MLO: mlr0157
MES: Meso_1082
SME: SM_b21278(adeC2) SMa1715(adeC3) SMa1718(adeC4) SMc01533(adeC1)
SMD: Smed_2318 Smed_4610 Smed_5275 Smed_5277
ATU: Atu2292(adeC) Atu4426(adeC)
ATC: AGR_C_4165 AGR_L_883
ARA: Arad_0238(ade) Arad_0264(ade) Arad_3279(ade) Arad_8961(ade)
AVI: Avi_3297(ade) Avi_5424(ade)
RET: RHE_CH03094(adeC1) RHE_CH03420(adeC2)
REC: RHECIAT_CH0003252(adeC1) RHECIAT_CH0003664(adeC2)
RLE: RL2014 RL3541(ade) RL3883(ade) RL4472(ade) pRL90169(ade)
RLT: Rleg2_2831 Rleg2_3164
RLG: Rleg_1650 Rleg_3101 Rleg_3451 Rleg_4006
RHI: NGR_c23700(adeC)
BME: BMEII0627
BMI: BMEA_B0626(ade)
BMF: BAB2_0587
BMB: BruAb2_0573(ade)
BMC: BAbS19_II05500
BMS: BRA0653(ade)
BMT: BSUIS_B0638(ade)
BOV: BOV_A0615(ade)
BCS: BCAN_B0653(ade)
BMR: BMI_II650(ade)
OAN: Oant_3735
BJA: bll6142 blr3165
BRA: BRADO2460 BRADO4947
BBT: BBta_3118
MEX: Mext_3431
MEA: Mex_1p3660(ade)
MDI: METDI4235(ade)
MRD: Mrad2831_2849
MET: M446_2226
MPO: Mpop_3626
MCH: Mchl_3740
MNO: Mnod_0385
SIL: SPO3746(ade)
SIT: TM1040_2799
RSP: RSP_0985
RSH: Rsph17029_2645
RSQ: Rsph17025_0239
RSK: RSKD131_2377
JAN: Jann_0338 Jann_3233
RDE: RD1_0605(ade)
PDE: Pden_2836
DSH: Dshi_0998(ade)
GOX: GOX1719
GDI: GDI_2526
GDJ: Gdia_0768
BSU: BSU06560(yerA) BSU14520(adeC)
BHA: BH0637 BH0640(adeC)
BAN: BA3032
BAR: GBAA3032
BAA: BA_3541
BAT: BAS2818
BAH: BAMEG_1576
BAI: BAA_3082
BCE: BC3012
BCZ: BCZK2753(ade)
BCR: BCAH187_A3063
BCB: BCB4264_A3029
BCU: BCAH820_3026
BCG: BCG9842_B2218
BCQ: BCQ_2842(ade)
BCX: BCA_3097
BTK: BT9727_2766(ade)
BTL: BALH_2712
BWE: BcerKBAB4_2823
BLI: BL01492(yerA) BL01613(adeC)
BLD: BLi00711(yerA) BLi01667(adeC)
BCL: ABC1075 ABC1077(adeC) ABC3209
BAY: RBAM_006960(yerA) RBAM_014260(adeC)
BPU: BPUM_0617(yerA) BPUM_1348(adeC)
OIH: OB0751 OB1030(adeC)
GKA: GK0271 GK1989 GK2098
GTN: GTNG_0250 GTNG_1889(adeC)
GWC: GWCH70_0266
GYM: GYMC10_6021
GYC: GYMC61_1142 GYMC61_2826 GYMC61_2923
AFL: Aflv_0242 Aflv_0257(adeC)
LMO: lmo1742(adeC)
LMF: LMOf2365_1767(ade)
LMH: LMHCC_0823(ade)
LMC: Lm4b_01756(adeC)
LIN: lin1853
LWE: lwe1759(adeC)
LSP: Bsph_0221 Bsph_3357
ESI: Exig_0459 Exig_0498
EAT: EAT1b_2236 EAT1b_2271
BBE: BBR47_06120 BBR47_14750 BBR47_56850
PJD: Pjdr2_1876
LPL: lp_3334(adeC)
LPJ: JDM1_2672(adeC)
LSA: LSA0088(adeC1) LSA1670(adeC2)
LSL: LSL_0929(adeC)
LDB: Ldb2182(adeC)
EFA: EF1222(ade)
OOE: OEOE_0158 OEOE_1462
LME: LEUM_0683
LCI: LCK_00627(ade)
CAC: CAC0887(adeC)
CPE: CPE1268(adeC)
CPF: CPF_1476
CDF: CD1820(ade)
CDC: CD196_1740(ade)
CDL: CDR20291_1715(ade)
CBO: CBO0294(ade)
CBA: CLB_0338(ade)
CBH: CLC_0353(ade)
CBY: CLM_0352(ade)
CBL: CLK_3488(ade)
CBK: CLL_A1394(ade)
CBB: CLD_0456(ade)
CBI: CLJ_B0349(ade)
CBT: CLH_1323(ade)
CBF: CLI_0367(ade)
CBE: Cbei_1277 Cbei_1975
AMT: Amet_4567 Amet_4574
AOE: Clos_0372 Clos_0379
VPR: Vpar_0775
DSY: DSY3665
DHD: Dhaf_1712
DRM: Dred_2771
DAE: Dtox_0973 Dtox_3359
CHY: CHY_0689(ade1) CHY_0699(ade2)
MTA: Moth_0463
SRO: Sros_2141
FRE: Franean1_5687
FAL: FRAAL1454
RXY: Rxyl_0377 Rxyl_1744
AFO: Afer_0084
ELE: Elen_1972
BBZ: BbuZS7_K13(adeC)
BHY: BHWA1_01698(adeC)
PDI: BDI_2966
SRU: SRU_2375(ade)
DFE: Dfer_5735
CPI: Cpin_1198
FPS: FP1059(adeC)
STR: Sterm_1555
OTE: Oter_3584
MIN: Minf_2333(adeC)
TAI: Taci_0428
DET: DET0791(ade)
DEH: cbdb_A769(adeC)
DEB: DehaBAV1_0717
DEV: DhcVS_697(ade)
TRO: trd_1190(ade)
STI: Sthe_1378
DRA: DR_A0270
DGE: Dgeo_0420
DDR: Deide_04190(ade)
TLE: Tlet_1344
TME: Tmel_1731
TAF: THA_28
PMO: Pmob_1744
KOL: Kole_2088
MFE: Mefer_0127
MVU: Metvu_1073
MAE: Maeo_0932
MAC: MA2310(adeC)
MBA: Mbar_A3342
MMA: MM_2910
MBU: Mbur_0733
MTP: Mthe_0522
MLA: Mlab_1602 Mlab_1603
MEM: Memar_1539
MBN: Mboo_1575
MPL: Mpal_1778
MTH: MTH866
MST: Msp_1308(ade)
MSI: Msm_0874
MKA: MK0829(adeC)
AFU: AF0240(adeC)
PTO: PTO1085
SMR: Smar_0382
DKA: DKAM_0242
NMR: Nmar_1578
KCR: Kcr_0371
 |
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| Structures |
PDB: 2ICS |
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Reference
Authors
Title
Journal
|
1
Blauch, M., Koch, F.C. and Hane, M.E.
A study of xanthine oxidase of rat blood.
J. Biol. Chem. 130 (1939) 471-486. |
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Reference
Authors
Title
Journal
|
2
Heppel, L.A., Hurwitz, J. and Horecker, B.L.
Adenine deaminase of Azotobacter vinelandii.
J. Am. Chem. Soc. 79 (1957) 630-633. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.4.2
IUBMB Enzyme Nomenclature: 3.5.4.2
ExPASy - ENZYME nomenclature database: 3.5.4.2
BRENDA, the Enzyme Database: 3.5.4.2
CAS: 9027-68-3 |
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