KEGG   ENZYME: 3.5.4.20Help
Entry
EC 3.5.4.20                 Enzyme                                 
Name
pyrithiamine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase
Reaction(IUBMB)
1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3 [RN:R04641]
Reaction(KEGG)
R04641;
(other) R06137
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Substrate
1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide [CPD:C04905];
H2O [CPD:C00001]
Product
1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide [CPD:C04908];
NH3 [CPD:C00014]
Reference
1  [PMID:5641872]
  Authors
Sinha AK, Chatterjee GC.
  Title
Metabolism of pyrithiamine by the pyrithiamine-requiring mutant of Staphylococcus aureus.
  Journal
Biochem. J. 107 (1968) 165-9.
  Organism
Staphylococcus aureus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37289-23-9
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