KEGG   ENZYME: 3.5.4.25Help
Entry
EC 3.5.4.25                 Enzyme                                 
Name GTP cyclohydrolase II;
guanosine triphosphate cyclohydrolase II;
GTP-8-formylhydrolase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname GTP 7,8-8,9-dihydrolase (diphosphate-forming)
Reaction(IUBMB) GTP + 3 H2O = formate +
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine +
diphosphate [RN:R00425]
Reaction(KEGG) R00425
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Substrate GTP [CPD:C00044];
H2O [CPD:C00001]
Product formate [CPD:C00058];
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine;
diphosphate [CPD:C00013]
Comment Two C-N bonds are hydrolysed, releasing formate, with simultaneous
removal of the terminal diphosphate.
Pathway PATH: ec00740  Riboflavin metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01497  GTP cyclohydrolase II
Genes ATH: AT2G22450 AT5G59750 AT5G64300(ATGCH)
POP: POPTR_1069506 POPTR_172824 POPTR_217377
RCU: RCOM_0300960 RCOM_0338130
VVI: 100248717 100267389
OSA: 4329733(Os02g0572400) 4339017(Os05g0460600)
SBI: SORBI_04g023640(SORBIDRAFT_04g023640)
     SORBI_09g022620(SORBIDRAFT_09g022620)
ZMA: 100282823
PPP: PHYPADRAFT_166811
CRE: CHLREDRAFT_102099
OLU: OSTLU_15668 OSTLU_87976
CME: CMP119C
SCE: YBL033C(RIB1)
AGO: AGOS_ADL296C
KLA: KLLA0B12375g
PIC: PICST_30471(RIB1)
CGR: CAGL0F04279g
YLI: YALI0E02288g
SPO: SPAP27G11.09c
NCR: NCU07188
MGR: MGG_10689
ANI: AN0670.2
AFM: AFUA_1G13300
AOR: AO090012000551
ANG: An08g06370
CNE: CNA05500
UMA: UM04826.1
PTI: PHATRDRAFT_6454
TPS: THAPSDRAFT_28100
ECO: b1277(ribA)
ECJ: JW1269(ribA)
ECD: ECDH10B_1394(ribA)
EBW: BWG_1108(ribA)
ECE: Z2531(ribA)
ECS: ECs1850(ribA)
ECF: ECH74115_1911(ribA)
ETW: ECSP_1797(ribA)
ECG: E2348C_1469(ribA)
ECC: c1746(ribA)
ECI: UTI89_C1548(ribA)
ECP: ECP_1330(ribA)
ECV: APECO1_437(ribA)
ECW: EcE24377A_1479(ribA)
ECX: EcHS_A1388(ribA)
ECM: EcSMS35_1852(ribA)
ECY: ECSE_1327(ribA)
ECL: EcolC_2349(ribA)
ECK: EC55989_1438(ribA)
ECQ: ECED1_1487(ribA)
ECR: ECIAI1_1300(ribA)
ECT: ECIAI39_1618(ribA)
ECZ: ECS88_1417(ribA)
EUM: ECUMN_1579(ribA)
ELF: LF82_1877(ribA)
EBL: B21_01265(ribA)
EBD: ECBD_2342
EBR: ECB_01254(ribA)
EOH: ECO103_1440(ribA)
EOI: ECO111_1658(ribA)
EOJ: ECO26_1843(ribA)
EFE: EFER_1677(ribA)
STY: STY1340(ribA)
STT: t1624(ribA)
SPT: SPA1165(ribA)
SEK: SSPA1084(ribA)
SPQ: SPAB_01540(ribA)
SEI: SPC_2020(ribA)
SEC: SC1706(ribA)
SEH: SeHA_C1898(ribA)
SEE: SNSL254_A1835(ribA)
SEW: SeSA_A1840(ribA)
SEA: SeAg_B1438(ribA)
SED: SeD_A1619(ribA)
SEG: SG1403(ribA)
SET: SEN1322(ribA)
SES: SARI_01251(ribA)
STM: STM1711(ribA)
YPE: YPO2222(ribA)
YPK: y2064(ribA)
YPM: YP_2020(ribA)
YPA: YPA_1581(ribA)
YPN: YPN_1690(ribA)
YPG: YpAngola_A2231(ribA)
YPP: YPDSF_0912(ribA)
YPS: YPTB2144(ribA)
YPI: YpsIP31758_1919(ribA) YpsIP31758_B0062(ribA)
YPY: YPK_2029(ribA)
YPB: YPTS_2214(ribA)
YEN: YE1965(ribA)
SFL: SF1281(ribA)
SFX: S1364(ribA)
SFV: SFV_1290(ribA)
SSN: SSON_1863(ribA)
SBO: SBO_1787(ribA)
SBC: SbBS512_E1505(ribA)
SDY: SDY_1353(ribA)
ECA: ECA1943(ribA)
PCT: PC1_2371
PWA: Pecwa_2653
ETA: ETA_16170(ribA)
PLU: plu2431(ribA) plu2474(ribA)
PAY: PAU_02078(ribA) PAU_02346(ribA)
BUC: BU271(ribA)
BAS: BUsg261(ribA)
BAB: bbp252(ribA)
BAP: BUAP5A_266(ribA)
BAU: BUAPTUC7_268(ribA)
WBR: WGLp364(ribA)
SGL: SG1410(ribA)
ENT: Ent638_2191(ribA)
ESA: ESA_01575(ribA)
KPN: KPN_01273(ribA)
KPE: KPK_3161(ribA)
KPU: KP1_2316(ribA)
CKO: CKO_01360(ribA)
SPE: Spro_2653(ribA)
PMR: PMI1317(ribA)
EIC: NT01EI_2353
BFL: Bfl425(ribA)
BPN: BPEN_437(ribA)
HDE: HDEF_0118(ribA)
DDA: Dd703_1699
DZE: Dd1591_1732
HIN: HI0212(ribA)
HIT: NTHI0309(ribA)
HIP: CGSHiEE_02170(ribA)
HIQ: CGSHiGG_03675(ribA)
HDU: HD1163(ribAB)
HAP: HAPS_1136(ribA)
HSO: HS_1043(ribA)
HSM: HSM_1520(ribA)
PMU: PM0677(ribA)
MSU: MS1533(ribA)
APL: APL_0384(ribA)
APJ: APJL_0404(ribA)
APA: APP7_0408
ASU: Asuc_1502(ribA)
AAP: NT05HA_0625
AAT: D11S_1693
XFA: XF0953 XF1992
XFT: PD0817(ribA) PD1745
XFM: Xfasm12_1906
XFN: XfasM23_1846
XCC: XCC0696(ribA) XCC3740(ribA)
XCB: XC_3538 XC_3810
XCA: xccb100_3659 xccb100_3921(ribA)
XCV: XCV0801(ribB) XCV3916
XAC: XAC0749(ribA) XAC3792(ribA)
XOO: XOO0594(ribA) XOO3853(ribA)
XOM: XOO_0555 XOO_3632
XOP: PXO_04398(ribAB)
SML: Smlt0728(ribB) Smlt4168
SMT: Smal_0582
VCH: VC1263(ribA) VC2269
VCO: VC0395_A0882(ribA) VC0395_A1859(ribB)
VCM: VCM66_1218(ribA) VCM66_2192(ribB)
VCJ: VCD_002073 VCD_003088
VVU: VV1_0321 VV1_2234(ribA) VV2_1180
VVY: VV0863 VV2120(ribA) VVA0006
VPA: VP0681 VP1921(ribA) VPA0006
VHA: VIBHAR_01168 VIBHAR_02717(ribA)
VSP: VS_2411
VEX: VEA_000986 VEA_003122 VEA_004263
VFI: VF_0702(ribB) VF_1189(ribA)
VFM: VFMJ11_0722(ribBA) VFMJ11_1267(ribA)
VSA: VSAL_I0924(ribBA) VSAL_I1787(ribA)
PPR: PBPRA0799 PBPRA1519 PBPRA1520 PBPRB1461
PAE: PA4047(ribA) PA4054(ribB)
PAU: PA14_11420(ribB) PA14_11510(ribA)
PAP: PSPA7_1047(ribB) PSPA7_1054(ribA)
PAG: PLES_09221(ribB) PLES_09291(ribA)
PPU: PP_0516(ribBA-1) PP_0522(ribA) PP_3813(ribBA-2)
PPF: Pput_0551 Pput_0557(ribA) Pput_1956
PPG: PputGB1_0562 PputGB1_0568(ribA) PputGB1_2092
PPW: PputW619_0569 PputW619_0575(ribA) PputW619_1936
PST: PSPTO_0692(ribBA-1) PSPTO_0696(ribA) PSPTO_2668(ribBA-2)
PSB: Psyr_2402 Psyr_4456(ribA) Psyr_4460
PSP: PSPPH_2560(ribBA1) PSPPH_4501(ribA) PSPPH_4505(ribBA2)
PFL: PFL_1034(ribA) PFL_5514(ribA) PFL_5520(ribA)
PFO: Pfl01_3240 Pfl01_5011(ribA) Pfl01_5017
PFS: PFLU2344 PFLU5466(ribA) PFLU5471(ribB)
PEN: PSEEN0590(ribB) PSEEN0596(ribA) PSEEN3037(ribB)
PMY: Pmen_3446 Pmen_3848(ribA) Pmen_3855
PSA: PST_0837(ribBA-1) PST_0843(ribA)
CJA: CJA_2689(ribA) CJA_2695(ribB)
AVN: Avin_06740(ribB) Avin_06800 Avin_43690(ribAB)
PAR: Psyc_0093(ribB) Psyc_0220(ribA)
PCR: Pcryo_0102 Pcryo_0244
PRW: PsycPRwf_0256 PsycPRwf_0410
ACI: ACIAD3249(ribA) ACIAD3570(ribB)
ACB: A1S_3107(ribA) A1S_3388
ABM: ABSDF0388(ribA) ABSDF3573(ribB)
ABY: ABAYE0096(ribB) ABAYE0379(ribA)
ABC: ACICU_03308(ribA) ACICU_03588
ABN: AB57_3559(ribA) AB57_3838
ABB: ABBFA_000095 ABBFA_000404(ribA)
SON: SO_2831(ribA) SO_3467(ribBA)
SDN: Sden_1146 Sden_1447(ribA)
SFR: Sfri_1037 Sfri_2438(ribA)
SAZ: Sama_1018 Sama_1277(ribA)
SBL: Sbal_1668(ribA) Sbal_3158
SBM: Shew185_1653(ribA) Shew185_3156
SBN: Sbal195_1690(ribA) Sbal195_3301
SBP: Sbal223_1213 Sbal223_2690(ribA)
SLO: Shew_1189 Shew_2446(ribA)
SPC: Sputcn32_1543(ribA) Sputcn32_2776
SSE: Ssed_1275 Ssed_1603(ribA)
SPL: Spea_1164 Spea_2616(ribA)
SHE: Shewmr4_1098 Shewmr4_2438(ribA)
SHM: Shewmr7_1164 Shewmr7_2508(ribA)
SHN: Shewana3_1098 Shewana3_2600(ribA)
SHW: Sputw3181_1236 Sputw3181_2556(ribA)
SHL: Shal_1207 Shal_2689(ribA)
SWD: Swoo_1384 Swoo_3046(ribA)
SWP: swp_1341 swp_3162(ribA)
ILO: IL1869(ribAB)
CPS: CPS_0732(ribB) CPS_1824(ribA) CPS_4061(ribA)
PHA: PSHAa0529(ribA) PSHAa2372(ribB)
PAT: Patl_1313 Patl_3961
SDE: Sde_3450(ribA) Sde_3456
MAQ: Maqu_0844 Maqu_2439(ribA)
AMC: MADE_01420
PIN: Ping_0518(ribA) Ping_1442
TTU: TERTU_3702(ribAB)
CBU: CBU_0647(ribA)
CBS: COXBURSA331_A0762(ribAB)
CBD: CBUD_0658(ribAB)
CBG: CbuG_1357(ribA)
CBC: CbuK_1609(ribA)
LPN: lpg1179(ribA)
LPF: lpl1188(ribA)
LPP: lpp1182(ribA)
LPC: LPC_0646(ribA)
MCA: MCA1656(ribBA) MCA2476
FTU: FTT_1673(ribA)
FTF: FTF1673(ribA)
FTW: FTW_1944(ribAB)
FTL: FTL_0076
FTH: FTH_0072(ribA)
FTA: FTA_0084(ribAB)
FTM: FTM_0047
FTN: FTN_0112(ribAB)
FPH: Fphi_0715
TCX: Tcr_1398
NOC: Noc_2023
AEH: Mlg_0377
HHA: Hhal_0898
TGR: Tgr7_1561
HNA: Hneap_1867
HCH: HCH_05867(ribA) HCH_05955
CSA: Csal_0115 Csal_1172 Csal_2584
ABO: ABO_2172(dhbP)
MMW: Mmwyl1_2026(ribA)
AHA: AHA_1807(ribA) AHA_3331
ASA: ASA_0981(ribBA) ASA_1766(ribA)
TAU: Tola_1268 Tola_1828 Tola_2523
DNO: DNO_0472(ribB)
AFE: Lferr_0475
AFR: AFE_0299(ribBA)
BCI: BCI_0300(ribA)
RMA: Rmag_0505
VOK: COSY_0463(ribAB)
KKO: Kkor_0473
NMA: NMA1425(ribA) NMA1429(ribB)
NME: NMB1254(ribA) NMB1256(ribA)
NMC: NMC1155(ribA) NMC1157(ribB)
NMN: NMCC_1137(ribA) NMCC_1139(ribB)
NMI: NMO_1070(ribB)
NGO: NGO0704 NGO1134(ribA)
NGK: NGK_1194 NGK_1475(ribA)
CVI: CV_2005(ribA) CV_2389(ribAB)
LHK: LHK_02390
RSO: RSc0713(ribAB)
RPI: Rpic_0662
RPF: Rpic12D_0706
REU: Reut_A0770 Reut_A1536 Reut_B4241 Reut_B5741
REH: H16_A2854(ribBA) H16_B0632 H16_B1576(ribA)
RME: Rmet_0194 Rmet_2693
CTI: RALTA_A2338(ribAB1) RALTA_B0481(ribAB2)
BMA: BMA2145(ribBA) BMAA1048(ribA) BMAA1349(ribA)
BMV: BMASAVP1_0035(ribA) BMASAVP1_0332(ribA) BMASAVP1_A0764(ribBA)
BML: BMA10229_0379(ribA) BMA10229_0610(ribA) BMA10229_A2597(ribBA)
BMN: BMA10247_2016(ribBA) BMA10247_A0959(ribA) BMA10247_A1205(ribA)
BPS: BPSL2626(ribB) BPSS0883(ribA) BPSS1121(ribA)
BPM: BURPS1710b_3102(ribBA) BURPS1710b_A0081(ribA)
     BURPS1710b_A2481(ribA)
BPL: BURPS1106A_3069(ribBA) BURPS1106A_A1220(ribA)
     BURPS1106A_A1501(ribA)
BPD: BURPS668_3016 BURPS668_A1292(ribA) BURPS668_A1584(ribA)
BPR: GBP346_A3206(ribBA)
BTE: BTH_I1531 BTH_II1285(ribA) BTH_II1514(ribA)
BVI: Bcep1808_0874 Bcep1808_5269 Bcep1808_5421
BUR: Bcep18194_A4058 Bcep18194_B1027 Bcep18194_B1621
BCN: Bcen_0478 Bcen_3636 Bcen_4914
BCH: Bcen2424_0957 Bcen2424_3249 Bcen2424_4731
BCM: Bcenmc03_0919 Bcenmc03_5551
BCJ: BCAL3053(ribB) BCAM1524
BAM: Bamb_0818 Bamb_1629(ribA) Bamb_4122 Bamb_6505
BAC: BamMC406_0827 BamMC406_4586
BMU: Bmul_2440 Bmul_3944
BMJ: BMULJ_00793(ribA) BMULJ_04557(ribA)
BXE: Bxe_A0893 Bxe_B1675
BPH: Bphy_0619 Bphy_3240
BPY: Bphyt_3101 Bphyt_4975
BGL: bglu_1g07940 bglu_2g14580
PNU: Pnuc_0266
PNE: Pnec_0292
BPE: BP3484(ribB)
BPA: BPP0857(ribB)
BBR: BB0951(ribB)
BPT: Bpet3958(ribB2)
BAV: BAV0569(ribB)
RFR: Rfer_2668
POL: Bpro_2885
PNA: Pnap_2917
AAV: Aave_2232
AJS: Ajs_2766
VEI: Veis_4791
DAC: Daci_2468
DIA: Dtpsy_2256
VAP: Vapar_3110
CTT: CtCNB1_3334
MPT: Mpe_A2947
HAR: HEAR0565(ribA) HEAR1036(ribB)
MMS: mma_0548(ribA) mma_2340(ribBA)
LCH: Lcho_0855 Lcho_2935
NEU: NE2556(ribAB)
NET: Neut_2516
NMU: Nmul_A0010
EBA: ebA3120(ribA) ebA3567(ribAB)
AZO: azo0319(ribAB)
DAR: Daro_3737
TBD: Tbd_2190
MFA: Mfla_1358 Mfla_2098
MMB: Mmol_0639
MEI: Msip34_0631
APP: CAP2UW1_4319
HPY: HP0802(ribA) HP0804
HPJ: jhp0738(ribA) jhp0740(ribBA)
HPA: HPAG1_0787(ribA) HPAG1_0789
HPS: HPSH_02795 HPSH_02805(ribA)
HPG: HPG27_758(ribA) HPG27_760
HPP: HPP12_0808(ribA) HPP12_0810
HPB: HELPY_0555(ribBA)
HHE: HH0044(ribA) HH0208
HAC: Hac_0920(ribA) Hac_0924(ribA)
WSU: WS1194(ribA) WS1222(ribA)
TDN: Suden_0384(ribA) Suden_1189
CJE: Cj0572(ribA) Cj0996(ribA)
CJR: CJE0675(ribB) CJE1076(ribA)
CJJ: CJJ81176_0600(ribB) CJJ81176_1014(ribA)
CJU: C8J_0534(ribB) C8J_0933(ribA)
CJD: JJD26997_0793(ribA) JJD26997_1098(ribB)
CFF: CFF8240_0999 CFF8240_1575(ribA)
CCV: CCV52592_1346(ribA) CCV52592_1408(fixO)
CHA: CHAB381_1325 CHAB381_1699(ribA)
CCO: CCC13826_0883(ribA) CCC13826_1413
CLA: Cla_0604(ribB) Cla_1128(ribA)
ABU: Abu_1228(ribAB) Abu_1237(ribA)
SDL: Sdel_0906
NIS: NIS_0359(ribA) NIS_0682
SUN: SUN_1141 SUN_2088(ribA)
NAM: NAMH_0543(ribA) NAMH_0693
GSU: GSU1690(ribA)
GME: Gmet_1626
GUR: Gura_2181
GLO: Glov_0881 Glov_1289 Glov_1751
GBM: Gbem_3022
GEO: Geob_2677
GEM: GM21_1228 GM21_2782
PCA: Pcar_1447
PPD: Ppro_1652
DVU: DVU1199(ribAB)
DVL: Dvul_1858
DVM: DvMF_3093
DDE: Dde_2436
DDS: Ddes_2136
DMA: DMR_04610(ribB)
DSA: Desal_0653
LIP: LI0155(ribA)
DBA: Dbac_0060
DRT: Dret_1422
BBA: Bd3038(ribA)
DPS: DP1100
DOL: Dole_2077
DAL: Dalk_3314
DAT: HRM2_31250(ribAB)
ADE: Adeh_0508 Adeh_1663 Adeh_2740
ACP: A2cp1_0537 A2cp1_2283 A2cp1_2924
AFW: Anae109_2140 Anae109_2729
ANK: AnaeK_0541 AnaeK_2194 AnaeK_2832
MXA: MXAN_3410(ribBA) MXAN_4213(ribA)
SCL: sce4848(ribA2) sce5281(ribA3) sce7267(ribA4)
HOH: Hoch_3479
SAT: SYN_02371
SFU: Sfum_1380
WOL: WD0003(ribA)
WBM: Wbm0278
WRI: WRi_000040
WPI: WPa_1254(ribA)
AMA: AM1317(ribA)
AMF: AMF_997(ribA)
ACN: ACIS_00089(ribA)
APH: APH_1314(ribA)
ERU: Erum0310
ERW: ERWE_CDS_00180(ribA)
ERG: ERGA_CDS_00180(ribA)
ECN: Ecaj_0023
ECH: ECH_0045
NSE: NSE_0649(ribB) NSE_0745(ribA)
NRI: NRI_0622(ribB)
PUB: SAR11_1044(ribA)
MLO: mlr7463
MES: Meso_0731
PLA: Plav_2912
SME: SMc00008(ribA)
SMD: Smed_0516
ATU: Atu0753(ribA)
ATC: AGR_C_1366
ARA: Arad_1211(ribA)
AVI: Avi_1014(ribA)
RET: RHE_PD00121(ribA)
REC: RHECIAT_CH0001030(ribA) RHECIAT_PB0000140(ribA)
RLE: RL1006(ribA)
RLT: Rleg2_0585
RLG: Rleg_0626
RHI: NGR_c05210(ribA)
LAS: CLIBASIA_01220
BME: BMEI1505
BMF: BAB1_0455
BMC: BAbS19_I04200
BMS: BR0429(ribAB)
BMT: BSUIS_A0455(ribB)
BOV: BOV_0436(ribAB)
BCS: BCAN_A0433(ribB)
BMR: BMI_I432(ribAB)
OAN: Oant_0540
BJA: blr2615(ribA)
BRA: BRADO2133
BBT: BBta_2450
RPA: RPA1093(ribB)
RPB: RPB_1161
RPC: RPC_4298
RPD: RPD_1263
RPE: RPE_4357
RPT: Rpal_1283
NWI: Nwi_0607
NHA: Nham_0752
OCA: OCAR_6921(ribBA)
BHE: BH04330(ribA)
BQU: BQ03520(ribA)
BBK: BARBAKC583_0398(ribBA)
BTR: Btr_0646(ribA)
BGR: Bgr_04650(ribA)
XAU: Xaut_2038 Xaut_4136
AZC: AZC_3102 AZC_4172
MEX: Mext_2991
MEA: Mex_1p3198(ribAB)
MDI: METDI3762(ribAB)
MRD: Mrad2831_2755
MET: M446_0391 M446_2360
MPO: Mpop_3177
MCH: Mchl_3217
MNO: Mnod_0250 Mnod_1874
BID: Bind_0944
MSL: Msil_0845
CCR: CC_0887
CCS: CCNA_00931
PZU: PHZ_c3296(ribAB)
SIL: SPO1761 SPO3427(ribBA)
SIT: TM1040_0050 TM1040_2129
RSP: RSP_0757(ribBA) RSP_0846(ribA)
RSH: Rsph17029_2414 Rsph17029_2504
RSQ: Rsph17025_0420 Rsph17025_3129
RSK: RSKD131_2117 RSKD131_2215
JAN: Jann_0416 Jann_3414
RDE: RD1_0043(ribA) RD1_1801(ribB)
PDE: Pden_1555 Pden_2375
DSH: Dshi_0039(ribA) Dshi_2251(ribB)
MMR: Mmar10_1533
HNE: HNE_2056(ribAB)
HBA: Hbal_1377
ZMO: ZMO0474 ZMO1698
ZMN: Za10_0780 Za10_1521
NAR: Saro_1473 Saro_1582 Saro_3191
SAL: Sala_2672 Sala_2981
SWI: Swit_1004 Swit_2445 Swit_3771 Swit_3789
ELI: ELI_05765 ELI_11975
GOX: GOX0980
GBE: GbCGDNIH1_1005
ACR: Acry_2119 Acry_2815
GDI: GDI_1152(ribAB)
GDJ: Gdia_1865
APT: APA01_18560
RRU: Rru_A1823 Rru_A3637
RCE: RC1_1338(ribAB) RC1_2933(ribA)
MAG: amb0020 amb2344
MGM: Mmc1_0166
BSU: BSU23260(ribA)
BHA: BH1556(ribA)
BAN: BA4333(ribBA)
BAR: GBAA4333(ribBA)
BAA: BA_4791
BAT: BAS4020
BAH: BAMEG_4373(ribBA)
BAI: BAA_4355(ribBA)
BCE: BC3388 BC4111
BCA: BCE_4181(ribBA)
BCZ: BCZK3097(ribBA) BCZK3867(ribA) pE33L466_0153(ribA)
BCR: BCAH187_A4245(ribBA)
BCB: BCB4264_A4222(ribBA)
BCU: BCAH820_4135(ribBA)
BCG: BCG9842_B1015(ribBA)
BCQ: BCQ_3901(ribBA)
BCX: BCA_4224(ribBA)
BCY: Bcer98_2810
BTK: BT9727_3853(ribA)
BTL: BALH_3727
BWE: BcerKBAB4_3943
BLI: BL01889(ribA)
BLD: BLi02473(ribA)
BCL: ABC1812(ribA)
BAY: RBAM_021400(ribA)
BPU: BPUM_2060(ribA)
OIH: OB0424 OB3214
GKA: GK2295
GTN: GTNG_2223
GWC: GWCH70_2237
GYM: GYMC10_2152
GYC: GYMC61_0387
AFL: Aflv_1017(ribA)
SAU: SA1587(ribA)
SAV: SAV1769(ribA)
SAW: SAHV_1754(ribA)
SAM: MW1709(ribA)
SAR: SAR1851(ribA)
SAS: SAS1692
SAC: SACOL1818(ribBA)
SAB: SAB1626c(ribA)
SAA: SAUSA300_1713(ribBA)
SAX: USA300HOU_1758(ribA)
SAO: SAOUHSC_01887
SAJ: SaurJH9_1821
SAH: SaurJH1_1856
SAE: NWMN_1660(ribA)
SAD: SAAV_1778(ribBA)
SEP: SE1439
SER: SERP1326(ribBA)
SHA: SH1155(ribA)
SSP: SSP0997
SCA: Sca_1373(ribA)
LSP: Bsph_1750 Bsph_2044(ribAB)
ESI: Exig_2714
EAT: EAT1b_1002
MCL: MCCL_1453
BBE: BBR47_48120(ribA)
PJD: Pjdr2_2351 Pjdr2_5321
AAC: Aaci_0938
LLA: L0165(ribA)
LLK: LLKF_1017(ribA)
LLC: LACR_1074
LLM: llmg_1530(ribA)
SPN: SP_0176
SPD: SPD_0167(ribB)
SPR: spr0162(ribA)
SPW: SPCG_0190(ribA)
SPX: SPG_0167
SNE: SPN23F_01730(ribA)
SPV: SPH_0279
SNM: SP70585_0239
SJJ: SPJ_0193
SPP: SPP_0233
SNT: SPT_0213
SAG: SAG0748(ribA)
SAN: gbs0769
SAK: SAK_0874(ribBA)
LPL: lp_1437(ribA)
LPJ: JDM1_1200(ribA)
LBR: LVIS_1651
LRE: Lreu_0880
LRF: LAR_0826
LFE: LAF_0774
PPE: PEPE_1818
LME: LEUM_0824
LCI: LCK_00764(ribA)
CAC: CAC0592(ribA)
CPE: CPE0568(ribA)
CPF: CPF_0548(ribA)
CPR: CPR_0532(ribA)
CTC: CTC00673(ribA)
CNO: NT01CX_0713
CTH: Cthe_0106
CDF: CD1698(ribA)
CDC: CD196_1621(ribA)
CDL: CDR20291_1596(ribA)
CBO: CBO2864(ribA)
CBA: CLB_2830(ribAB)
CBH: CLC_2763(ribAB)
CBY: CLM_3260(ribAB)
CBL: CLK_2261(ribAB)
CBK: CLL_A1297
CBB: CLD_1678(ribAB)
CBI: CLJ_B3118
CBT: CLH_1248
CBF: CLI_2920(ribAB)
CBE: Cbei_1226
CKL: CKL_2167(ribAB)
CKR: CKR_1902
CCE: Ccel_2004
AMT: Amet_1020
SWO: Swol_1220
VPR: Vpar_0952
ATE: Athe_0562
DSY: DSY1664(ribA)
DHD: Dhaf_2810
DRM: Dred_2091
DAE: Dtox_2298
PTH: PTH_1759
DAU: Daud_0625
HMO: HM1_2143(ribAB)
APR: Apre_1159
EEL: EUBELI_20112
ERE: EUBREC_3130
TEX: Teth514_0022
TPD: Teth39_0023
CHY: CHY_1473(ribBA)
MTA: Moth_0917
ADG: Adeg_1980
CSC: Csac_0792
NTH: Nther_0124
HOR: Hore_08550 Hore_10010
MMO: MMOB5970(ribA)
ACL: ACL_1321(ribBA)
MTU: Rv1415(ribA2) Rv1940(ribA1)
MTC: MT1458 MT1990
MRA: MRA_1424(ribA2) MRA_1950(ribA1)
MTF: TBFG_11444 TBFG_11969
MTB: TBMG_02052(TBMG_02052.1) TBMG_02565(TBMG_02565.1)
MBO: Mb1450(ribA2) Mb1975(ribA1)
MBB: BCG_1476(ribA2) BCG_1979(ribA1)
MBT: JTY_1451(ribA2) JTY_1963(ribA1)
MLE: ML0559(ribA)
MLB: MLBr_00559(ribA)
MPA: MAP1140(ribA2)
MAV: MAV_3365
MSM: MSMEG_3072
MUL: MUL_1809(ribA2) MUL_2886(ribA1)
MVA: Mvan_2694 Mvan_4000
MGI: Mflv_3719
MAB: MAB_2796c
MMC: Mmcs_2390
MKM: Mkms_2437
MJL: Mjls_2431
MMI: MMAR_2222(ribA2) MMAR_2868(ribA1)
CGL: NCgl1533(cgl1595)
CGB: cg1798(ribA)
CGT: cgR_1643
CEF: CE1714(ribA)
CDI: DIP1317(ribA)
CJK: jk1008(ribA)
CUR: cur_0983
CAR: cauri_1193(ribA)
CKP: ckrop_0976
NFA: nfa36000(ribBA)
RHA: RHA1_ro07170(ribA) RHA1_ro11048 RHA1_ro11307
RER: RER_30220(ribA)
ROP: ROP_69510(ribA)
GBR: Gbro_2355
SCO: SCO1441(ribAB) SCO2687(ribA) SCO6655(ribA2)
SMA: SAV_1791(ribA2) SAV_4121(ribA) SAV_545(ribA) SAV_6904(ribA1)
SGR: SGR_6092
TWH: TWT689 TWT690
TWS: TW708(ribB) TW709(ribA)
LXX: Lxx04350(ribA)
CMI: CMM_0961(ribAB)
CMS: CMS_2878(ribA)
ART: Arth_1677
ACH: Achl_1672 Achl_1773
RSA: RSal33209_2345
KRH: KRH_11700 KRH_11710(ribA)
MLU: Mlut_10870
BFA: Bfae_00080
JDE: Jden_0682
KSE: Ksed_01570
XCE: Xcel_1728
PAC: PPA1750
NCA: Noca_0866 Noca_1684(ribA) Noca_2449
TFU: Tfu_1080
TCU: Tcur_2995
SRO: Sros_2835
FRA: Francci3_3186
FRE: Franean1_1724
FAL: FRAAL5220(ribA)
ACE: Acel_1272
NML: Namu_4151
KRA: Krad_0125 Krad_2978
SEN: SACE_2123(ribA) SACE_2786(ribA) SACE_2884(ribA)
SVI: Svir_15730
AMI: Amir_3980 Amir_5218
STP: Strop_1877 Strop_2559(ribA)
SAQ: Sare_1870 Sare_2747(ribA)
CAI: Caci_1820 Caci_3108
BLN: Blon_0388
RXY: Rxyl_1366
AFO: Afer_1683
SHI: Shel_07110
CTR: CT731(ribA)
CTA: CTA_0793(ribA)
CTB: CTL0100(ribA)
CTL: CTLon_0100(ribA)
CTJ: JALI_7361(ribA)
CMU: TC0104(ribA)
CPN: CPn0872(ribA)
CPA: CP0997
CPJ: CPj0872(ribA_ribB)
CPT: CpB0901
CCA: CCA00895(ribA)
CAB: CAB863(ribA)
CFE: CF0119(ribA)
PCU: pc0890(ribA)
LIL: LA1147(ribA)
LIC: LIC12534(ribA)
LBJ: LBJ_2150(ribAB)
LBL: LBL_2144(ribAB)
LBI: LEPBI_I1406(ribBA)
LBF: LBF_1352(ribAB)
BHY: BHWA1_02028(ribAB)
ABA: Acid345_2148 Acid345_3140
ACA: ACP_0420(ribB)
SUS: Acid_1908 Acid_2182
BTH: BT_2416
BFR: BF0594
BFS: BF0544(ribA)
BVU: BVU_0143
PGI: PG0599(ribBA)
PGN: PGN_0643
PDI: BDI_3492
SRU: SRU_0007(rpe) SRU_0012(ribBA)
RMR: Rmar_2056
CHU: CHU_0931(ribA)
DFE: Dfer_4002
CPI: Cpin_5934
PHE: Phep_3561
GFO: GFO_2186(ribA)
FJO: Fjoh_2109
FPS: FP1589(ribBA)
FBA: FIC_00284
COC: Coch_1847
RBI: RB2501_14274
BBL: BLBBGE_323(ribBA)
BPI: BPLAN_317(ribB)
FSU: Fisuc_2736
FNU: FN1508
LBA: Lebu_1558
STR: Sterm_2778
OTE: Oter_1706
MIN: Minf_2430(ribA)
AMU: Amuc_0422
GAU: GAU_1473(ribBA)
RBA: RB12480(ribA)
RSD: TGRD_529
TAI: Taci_1008
SYN: sll1894(ribA)
SYW: SYNW1263(ribA)
SYC: syc0124_d(ribA)
SYF: Synpcc7942_1432
SYD: Syncc9605_1390
SYE: Syncc9902_1098
SYG: sync_1383(ribAB)
SYR: SynRCC307_1354(ribA)
SYX: SynWH7803_1252(ribA)
SYP: SYNPCC7002_A0427(ribAB)
CYA: CYA_2473(ribAB)
CYB: CYB_2077(ribAB)
TEL: tlr1727(ribA)
MAR: MAE_24490
CYT: cce_1078(ribA)
CYP: PCC8801_3439
CYC: PCC7424_1963
CYN: Cyan7425_2537
CYH: Cyan8802_2677
GVI: gvip130(ribA)
ANA: all3536
NPU: Npun_R3506
AVA: Ava_3515
PMA: Pro0943(ribB)
PMM: PMM0893(ribA)
PMT: PMT0708(ribA)
PMN: PMN2A_0317
PMI: PMT9312_0907
PMB: A9601_09681(ribB)
PMC: P9515_09751(ribB)
PMF: P9303_15131(ribB)
PMG: P9301_09661(ribB)
PMH: P9215_09991(ribB)
PMJ: P9211_08711(ribB)
PME: NATL1_09901(ribB)
TER: Tery_4462
AMR: AM1_0608(ribAB)
CTE: CT1591(ribBA)
CPC: Cpar_1519
CCH: Cag_1788
CPH: Cpha266_0600
CPB: Cphamn1_0629
CLI: Clim_1966
PVI: Cvib_1382
PLT: Plut_1591
PPH: Ppha_0726
PAA: Paes_0583
CTS: Ctha_1303
DET: DET1188(ribBA)
DEH: cbdb_A1103(ribA)
DEB: DehaBAV1_0999
DEV: DhcVS_971(ribBA)
CAU: Caur_0359 Caur_2201
CAG: Cagg_1299
CHL: Chy400_0386 Chy400_2372
HAU: Haur_1306
TRO: trd_0504
STI: Sthe_1970
DRA: DR_0155
DGE: Dgeo_0302
DDR: Deide_02250(ribAB)
TTH: TTC0697(ribA)
TTJ: TTHA1062
AAE: aq_350(ribA)
HYA: HY04AAS1_1340
SUL: SYO3AOP1_1761
SAF: SULAZ_0712
PMX: PERMA_1569
TMA: TM1826
TPT: Tpet_1111
TRQ: TRQ2_0995
TNA: CTN_0758
TNP: Tnap_1001
TME: Tmel_0043
TAF: THA_260(ribB)
FNO: Fnod_1417
KOL: Kole_1233
TYE: THEYE_A0208
TTR: Tter_2767
MTP: Mthe_1632
AFU: AF0484(ribA-1)
HUT: Huta_2029
TAC: Ta1014m(ribA)
TVO: TVN0575(ribA)
PTO: PTO0570(ribA)
PFU: PF0064
TKO: TK0428
TON: TON_0608
TGA: TGAM_1256(ribA)
Taxonomy
Structures PDB: 2BZ0  2BZ1  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:235552]
Foor F, Brown GM.
Purification and properties of guanosine triphosphate cyclohydrolase
II from Escherichia coli.
J. Biol. Chem. 250 (1975) 3545-51.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 3.5.4.25
IUBMB Enzyme Nomenclature: 3.5.4.25
ExPASy - ENZYME nomenclature database: 3.5.4.25
BRENDA, the Enzyme Database: 3.5.4.25
CAS: 56214-35-8
DBGET integrated database retrieval system