KEGG   ENZYME: 3.5.4.4Help
Entry
EC 3.5.4.4                  Enzyme                                 
Name adenosine deaminase;
deoxyadenosine deaminase
Class Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname adenosine aminohydrolase
Reaction(IUBMB) adenosine + H2O = inosine + NH3 [RN:R01560]
Reaction(KEGG) R01560;
(other) R02556 R06137
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Substrate adenosine [CPD:C00212];
H2O [CPD:C00001]
Product inosine [CPD:C00294];
NH3 [CPD:C00014]
Inhibitor Nebularine [CPD:C01736];
6-Hydroxyl-1,6-dihydropurine ribonucleoside [CPD:C04583]
Pathway PATH: ec00230  Purine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01488  adenosine deaminase
Genes HSA: 100(ADA)
PTR: 741760(ADA)
MCC: 710148 717897(ADA)
MMU: 11486(Ada)
RNO: 24165(Ada)
CFA: 477236(ADA)
BTA: 280712(ADA)
ECB: 100070773
MDO: 100011225
OAA: 100077360
GGA: 415391(RCJMB04_3k8) 418160(CECR1) 419194(ADA)
TGU: 100230548
XLA: 444167
XTR: 496434(ada)
DRE: 436919(ada)
BFO: BRAFLDRAFT_212041 BRAFLDRAFT_284837
CIN: 100184870
SPU: 580201 586781
DME: Dmel_CG10143(Adgf-E) Dmel_CG11994(Ada) Dmel_CG5992(Adgf-A)
     Dmel_CG5998(Adgf-B) Dmel_CG9621(Adgf-D)
DPO: Dpse_GA10106 Dpse_GA11319 Dpse_GA19282 Dpse_GA21919
DAN: Dana_GF13523 Dana_GF16581 Dana_GF18149 Dana_GF23892
DER: Dere_GG15092 Dere_GG15787 Dere_GG17028 Dere_GG22410
DPE: Dper_GL10635 Dper_GL18074 Dper_GL22286 Dper_GL24450
DSE: Dsec_GM20196 Dsec_GM23784 Dsec_GM24311 Dsec_GM25912
DSI: Dsim_GD12381 Dsim_GD18595 Dsim_GD20479 Dsim_GD25667
DYA: Dyak_GE12299 Dyak_GE22124 Dyak_GE24420 Dyak_GE25929
DGR: Dgri_GH14048 Dgri_GH15340 Dgri_GH19347 Dgri_GH22920
DMO: Dmoj_GI12945 Dmoj_GI22557 Dmoj_GI24423
AGA: AgaP_AGAP005158
AAG: AaeL_AAEL009191 AaeL_AAEL015233
CQU: CpipJ_CPIJ014249
AME: 410833
NVI: 100115242
TCA: 657502
ISC: IscW_ISCW005182
CBR: CBG05749 CBG05751
SMM: Smp_035700
NVE: NEMVE_v1g240431
HMG: 100201780
TAD: TRIADDRAFT_61081
ATH: AT4G04880
POP: POPTR_837657
RCU: RCOM_0905310
VVI: 100252204(GSVIVT00006894001)
OSA: 4344179(Os07g0661000)
SBI: SORBI_02g041950(SORBIDRAFT_02g041950)
ZMA: 100194033
PPP: PHYPADRAFT_195414
CRE: CHLREDRAFT_175699
OLU: OSTLU_5107
CME: CMH009C
SCE: YNL141W(AAH1)
KLA: KLLA0E23254g
LTH: KLTH0B06226g
PIC: PICST_59156(AAH1)
VPO: Kpol_1035p29
LEL: LELG_02420
ZRO: ZYRO0G05390g
CTP: CTRG_01761
CDU: CD36_21260
CGR: CAGL0J05984g
SPO: SPBC1198.02(dea2) SPBC1683.02
NCR: NCU04642
PAN: PODANSg7831
MGR: MGG_00770
FGR: FG01567.1 FG02383.1 FG10205.1
ANI: AN2494.2 AN6078.2
AFM: AFUA_1G13240 AFUA_2G09150 AFUA_3G15090
AOR: AO090011000062 AO090011000781 AO090026000211
ANG: An12g04800
AFV: AFLA_038790 AFLA_045840 AFLA_137210
PCS: Pc06g00210 Pc13g10630 Pc16g10530
NFI: NFIA_061990 NFIA_084680
CIM: CIMG_04330
SSL: SS1G_00820 SS1G_00879
BFU: BC1G_02118 BC1G_09011
LBC: LACBIDRAFT_315292
UMA: UM00564.1 UM01794.1
DDI: DDB_0230171
EHI: EHI_005040 EHI_014320
EDI: EDI_219150 EDI_240590
PFA: PF10_0289
PFD: PFDG_03636
PFH: PFHG_01287
PYO: PY02076
PCB: PC000803.01.0
PBE: PB000578.03.0
PKN: PKH_061390
PVX: PVX_111245
BBO: BBOV_I001470
TGO: TGME49_005720
TET: TTHERM_00703880 TTHERM_00780760 TTHERM_00895970 TTHERM_01321550
PTM: GSPATT00004773001
LMA: LmjF35.2160
LIF: LinJ19.1180
LBZ: LbrM34_V2.2090
TVA: TVAG_430670
PTI: PHATRDRAFT_22117 PHATRDRAFT_3559
TPS: THAPSDRAFT_37724 THAPS_23371
ECO: b1623(add)
ECJ: JW1615(add)
ECD: ECDH10B_1756(add)
EBW: BWG_1437(add)
ECE: Z2628(add)
ECS: ECs2331
ECF: ECH74115_2335(add)
ETW: ECSP_2187(add)
ECG: E2348C_1708(add)
ECC: c2015(add)
ECI: UTI89_C1811(add)
ECP: ECP_1567
ECV: APECO1_706(add)
ECW: EcE24377A_1831(add)
ECX: EcHS_A1698(add)
ECM: EcSMS35_1576(add)
ECY: ECSE_1744
ECL: EcolC_2007
ECK: EC55989_1790(add)
ECQ: ECED1_1823(add)
ECR: ECIAI1_1674(add)
ECT: ECIAI39_1434(add)
ECZ: ECS88_1670(add)
EUM: ECUMN_1913(add)
ELF: LF82_0033(add)
EBL: B21_01582(add)
EBD: ECBD_2022
EBR: ECB_01592(add)
EOH: ECO103_1763(add)
EOI: ECO111_2092(add)
EOJ: ECO26_2351(add)
EFE: EFER_1420(add)
STY: STY1658(add)
STT: t1331(add)
SPQ: SPAB_01857
SEI: SPC_2268(add)
SEC: SC1480(add)
SEH: SeHA_C1633(add)
SEE: SNSL254_A1573(add)
SEW: SeSA_A1561(add)
SEA: SeAg_B1711(add)
SED: SeD_A1879(add)
SEG: SG1655(add)
SET: SEN1584(add)
SES: SARI_01517
STM: STM1463(add)
YPS: YPTB2180(add)
YPI: YpsIP31758_1878(add)
YPY: YPK_1993
YPB: YPTS_2250
YEN: YE2009(add)
SFL: SF1648(add)
SFX: S1780(add)
SFV: SFV_1640(add)
SSN: SSON_1535(add)
SBO: SBO_1511(add)
SBC: SbBS512_E1811(add)
SDY: SDY_1846(add)
ECA: ECA2266(add)
PCT: PC1_2036
PWA: Pecwa_2337
ETA: ETA_17650(add)
PLU: plu2362(add) plu2772
PAY: PAU_01771 PAU_02155(add)
ENT: Ent638_1825
ESA: ESA_01980
CTU: Ctu_20130(add)
KPN: KPN_01958(add)
KPE: KPK_2390(add)
KPU: KP1_3027(add)
CKO: CKO_01630
SPE: Spro_2251
PMR: PMI1300(add)
EIC: NT01EI_2081 NT01EI_3391
ETR: ETAE_1705(add) ETAE_2979
DDA: Dd703_1904
DDC: Dd586_2087
DZE: Dd1591_2142
HDU: HD0377(add)
XCC: XCC0294(add)
XCB: XC_0304
XCA: xccb100_0319(add)
XCV: XCV0317(add)
XAC: XAC0308(add)
VCH: VC2751
VCO: VC0395_A2323(add)
VCM: VCM66_2671(add)
VCJ: VCD_001617
VVU: VV2_0468
VVY: VVA1020
VPA: VP0116 VPA1292
VHA: VIBHAR_00582 VIBHAR_06421
VSP: VS_II0073
VEX: VEA_000592 VEA_001910
VFI: VF_0093(add) VF_2580
VFM: VFMJ11_0091(add)
PPR: PBPRA3496 PBPRB1184 PBPRB1379
PAE: PA0148
PAU: PA14_01830(add)
PAP: PSPA7_0226(add)
PAG: PLES_01491
PPU: PP_0591(add)
PPF: Pput_0631
PPG: PputGB1_0636
PPW: PputW619_4572
PST: PSPTO_0757(add)
PSB: Psyr_0661
PSP: PSPPH_4636(add)
PFL: PFL_0719(add)
PFO: Pfl01_0671
PFS: PFLU0667
PEN: PSEEN0674(add)
PMY: Pmen_3706
PSA: PST_3608(add)
CJA: CJA_0563 CJA_0578 CJA_0584
AVN: Avin_22300
PCR: Pcryo_0456
ACI: ACIAD1245(add)
ACB: A1S_0718 A1S_1137
ABM: ABSDF1427(add) ABSDF2749(add)
ABY: ABAYE2601(add) ABAYE3101(add)
ABC: ACICU_00659 ACICU_01148
ABN: AB57_0763(add) AB57_1219(add)
ABB: ABBFA_002409(add) ABBFA_002899(add)
SON: SO_4731(add)
SDN: Sden_3627
SFR: Sfri_0041
SAZ: Sama_0085
SBL: Sbal_0046
SBM: Shew185_4352
SBN: Sbal195_4494
SBP: Sbal223_4297
SLO: Shew_3721
SPC: Sputcn32_3914
SSE: Ssed_2715 Ssed_3482 Ssed_3524
SPL: Spea_3392
SHE: Shewmr4_3912
SHM: Shewmr7_4004
SHN: Shewana3_4117
SHW: Sputw3181_0038
SHL: Shal_3477
SWD: Swoo_1121
SWP: swp_4887
ILO: IL0360(add)
CPS: CPS_1359(add1) CPS_1979(add2)
PHA: PSHAa0102(add)
PAT: Patl_2222 Patl_2390 Patl_2420
AMC: MADE_02509 MADE_03345
PIN: Ping_0692 Ping_1455
TTU: TERTU_2015 TERTU_3230(add)
LPN: lpg0580(add)
LPF: lpl0615(add)
LPP: lpp0631(add)
LPC: LPC_2723(add) LPC_2849(add)
FTU: FTT_0939c(add1)
FTF: FTF0939c(add1)
FTW: FTW_0833(add)
FTN: FTN_0695(add)
HNA: Hneap_0868
HCH: HCH_01503(add)
CSA: Csal_1983
MMW: Mmwyl1_1922
AHA: AHA_0273(add-1) AHA_2653(add-2)
ASA: ASA_2506(add) ASA_4124(add)
TAU: Tola_2207
AFE: Lferr_0916
AFR: AFE_0773(add)
LHK: LHK_01215(add)
RSO: RSc2098(add)
RPI: Rpic_2249
RPF: Rpic12D_1925
REU: Reut_A2428
REH: H16_A1014(add) H16_B2033
RME: Rmet_0890
CTI: RALTA_A0998(add)
BMA: BMA0461(add)
BMV: BMASAVP1_A2607(add)
BML: BMA10229_A0979(add)
BMN: BMA10247_0168(add)
BPS: BPSL2539(add)
BPM: BURPS1710b_3021(add)
BPL: BURPS1106A_2976(add)
BPD: BURPS668_2916(add)
BPR: GBP346_A3115(add)
BTE: BTH_I1612
BVI: Bcep1808_0939
BUR: Bcep18194_A4131 Bcep18194_B0389
BCN: Bcen_0541 Bcen_3107
BCH: Bcen2424_1020 Bcen2424_5260
BCM: Bcenmc03_0978 Bcenmc03_5013
BCJ: BCAL2989(add) BCAM2458
BAM: Bamb_0883 Bamb_4621
BAC: BamMC406_0895 BamMC406_5147
BMU: Bmul_2376
BMJ: BMULJ_00865(add)
BXE: Bxe_A0947
BPH: Bphy_0710 Bphy_3173 Bphy_3185
BPY: Bphyt_3044
BGL: bglu_1g08480
BPA: BPP1038(add)
BBR: BB1254(add)
BPT: Bpet3978(add)
BAV: BAV0774(add)
RFR: Rfer_3297
POL: Bpro_1487
PNA: Pnap_1040
AAV: Aave_1138
VEI: Veis_1083 Veis_2520
DAC: Daci_2144
DIA: Dtpsy_2442
VAP: Vapar_1681 Vapar_3887
CTT: CtCNB1_3677 CtCNB1_3831
MPT: Mpe_A0809
MMS: mma_1581(add)
LCH: Lcho_3742
AZO: azo0236(add)
TMZ: Tmz1t_0648
WSU: WS0737
CLA: Cla_0004
SDL: Sdel_0282
GUR: Gura_0478 Gura_2399 Gura_4130
GLO: Glov_1001
DSA: Desal_3039
BBA: Bd3476(add)
DPS: DP2081
DAL: Dalk_0176 Dalk_0515
ADE: Adeh_0098 Adeh_1249
ACP: A2cp1_0116 A2cp1_2709
AFW: Anae109_0100 Anae109_2517
ANK: AnaeK_0105 AnaeK_2615
MXA: MXAN_1519(add)
SCL: sce9006(add)
HOH: Hoch_0048 Hoch_0385
MLO: mll3163
MES: Meso_3659
SME: SMc04120(add)
SMD: Smed_3344
ATU: Atu0136(add)
ATC: AGR_C_218
ARA: Arad_0352(add)
AVI: Avi_0230(add)
RET: RHE_CH00197(add)
REC: RHECIAT_CH0000242(add)
RLE: RL0206
RLT: Rleg2_4180
RLG: Rleg_4468
RHI: NGR_c34590
RPC: RPC_4230
XAU: Xaut_4682
AZC: AZC_3915
CCR: CC_3180
CCS: CCNA_03284
CAK: Caul_0816 Caul_4066
PZU: PHZ_c3010(add)
SIL: SPO2927(add)
RSP: RSP_1597(add)
RSH: Rsph17029_0250
RSQ: Rsph17025_0278
RSK: RSKD131_2997
JAN: Jann_2984
PDE: Pden_2220
DSH: Dshi_0830(add)
MMR: Mmar10_1236
HNE: HNE_1938(add)
ZMO: ZMO0655 ZMO0971
ZMN: Za10_0330 Za10_0611
SAL: Sala_2009
SWI: Swit_2485
GOX: GOX1436
GDI: GDI_0783(add)
GDJ: Gdia_1233
RRU: Rru_A0766
RCE: RC1_3721(add)
SSP: SSP2398
PJD: Pjdr2_3310
LLA: L87453(add)
LLK: LLKF_0337(add)
LLC: LACR_0321
LLM: llmg_0299(add)
SAG: SAG0538
SAN: gbs0583
SAK: SAK_0688(add)
SMU: SMU.1295(add)
STC: str0750(add)
STL: stu0750(add)
STE: STER_0791
SSU: SSU05_0538
SSV: SSU98_0531 SSU98_0532
SSB: SSUBM407_1325
SSI: SSU0489
SSS: SSUSC84_0473
SEQ: SZO_12050
SEZ: Sez_0749(add)
SEU: SEQ_0877
SDS: SDEG_0692(add)
LJO: LJ1639
LJF: FI9785_1433
LAC: LBA1535
LSA: LSA0086(add)
LDB: Ldb1463(add)
LBU: LBUL_1358
LBR: LVIS_0278
LCA: LSEI_2207
LCB: LCABL_23880(add)
LGA: LGAS_1406
LHE: lhv_1760
LRH: LGG_02210(add)
LRL: LC705_02199(add)
EFA: EF0171(add)
LME: LEUM_0809
CAC: CAC3005(add)
CPE: CPE2506(add)
CPF: CPF_2829(add)
CPR: CPR_2515(add)
CDF: CD1747(add)
CDC: CD196_1666(add)
CDL: CDR20291_1641(add)
CBO: CBO0991(add)
CBA: CLB_1030(add)
CBH: CLC_1043(add)
CBY: CLM_1145(add)
CBL: CLK_0436(add)
CBB: CLD_3575(add)
CBI: CLJ_B1035(add)
CBF: CLI_1072(add)
CKL: CKL_0833(add)
CKR: CKR_0749
CPY: Cphy_3143
EEL: EUBELI_20502
ERE: EUBREC_0295 EUBREC_0394
MFL: Mfl215
MTU: Rv3313c(add)
MRA: MRA_3355(add)
MTF: TBFG_13344
MTB: TBMG_03362(TBMG_03362.1)
MBO: Mb3342c(add)
MBB: BCG_3379c(add)
MBT: JTY_3339(add_1)
MLE: ML0700(add)
MLB: MLBr_00700(add)
MPA: MAP3438c(add)
MAV: MAV_4294(add)
MSM: MSMEG_1676(add)
MUL: MUL_1364(add)
MVA: Mvan_1592
MGI: Mflv_4841
MAB: MAB_3670c
MMC: Mmcs_1233
MKM: Mkms_1250
MJL: Mjls_1259
MMI: MMAR_1206(add)
CJK: jk1687(add)
CUR: cur_0431
CKP: ckrop_1555
NFA: nfa9530
RHA: RHA1_ro06027(add1) RHA1_ro06251(add2)
RER: RER_20480(add) RER_41080(add)
ROP: ROP_60860(add) ROP_63100(add)
GBR: Gbro_1781
SCO: SCO2546(SCC77.13c) SCO4644(add) SCO4901(2SCK8.27)
     SCO5662(SC6A9.05) SCO7268(add)
SMA: SAV_1165(add1) SAV_2595(add2) SAV_3358(add3) SAV_4906(add4)
     SAV_5577(add5)
SGR: SGR_1841 SGR_2641 SGR_2878 SGR_4999
LXX: Lxx04660(add) Lxx13430(add)
CMI: CMM_0659(addB) CMM_0983(addA)
CMS: CMS_2855(add)
ART: Arth_0907 Arth_1145
AAU: AAur_1117(add) AAur_1261(add)
ACH: Achl_0997 Achl_1218
RSA: RSal33209_0327
KRH: KRH_17840(add)
MLU: Mlut_04960
BCV: Bcav_2936 Bcav_3173
BFA: Bfae_24030 Bfae_28230
JDE: Jden_0572 Jden_0831 Jden_1580
KSE: Ksed_21160
XCE: Xcel_0605 Xcel_1002
PAC: PPA2273
NCA: Noca_0674 Noca_1355 Noca_3533
TFU: Tfu_2563 Tfu_2662
TCU: Tcur_4185 Tcur_4359
SRO: Sros_1064 Sros_1279 Sros_2140 Sros_6019
FRA: Francci3_0534 Francci3_0686 Francci3_1770 Francci3_2382
     Francci3_4458
FRE: Franean1_2196 Franean1_5933 Franean1_6098
FAL: FRAAL1027 FRAAL1195(add) FRAAL1473 FRAAL6786
ACE: Acel_0264
NML: Namu_1320 Namu_4607
KRA: Krad_0670 Krad_1299 Krad_2063 Krad_3935 Krad_4351
SEN: SACE_1513(add) SACE_2180(add) SACE_3230(add) SACE_3612(add)
     SACE_6573(add)
SVI: Svir_05460
AMI: Amir_1459 Amir_6446
STP: Strop_0815 Strop_1779
SAQ: Sare_0759 Sare_1766
CAI: Caci_0789 Caci_7773
BLA: BLA_1473(add)
BLC: Balac_0959
BLT: Balat_0959
APV: Apar_0440
TPA: TP0045
TPP: TPASS_0045
TDE: TDE0188
LIL: LA3783
LIC: LIC10459(add)
LBJ: LBJ_0617(add)
LBL: LBL_2462(add)
LBI: LEPBI_I0038(add2)
LBF: LBF_0040(add)
ABA: Acid345_0045 Acid345_3059
ACA: ACP_1968 ACP_2020(add)
SUS: Acid_7334
SRU: SRU_0673(add)
RMR: Rmar_2501
FJO: Fjoh_3493
SMF: Smon_1214
OTE: Oter_3003
GAU: GAU_2355(add)
EMI: Emin_1162
SYC: syc1695_c
SYF: Synpcc7942_2410
CYA: CYA_1916
CYB: CYB_2006
TEL: tlr1233
MAR: MAE_50410
CYT: cce_0747 cce_4185
CYP: PCC8801_4213
CYC: PCC7424_3819
CYN: Cyan7425_1375
CYH: Cyan8802_4252
GVI: glr0121
ANA: all4418
NPU: Npun_F2195 Npun_F3248
AVA: Ava_1344
TER: Tery_3281
AMR: AM1_5316(add)
CPH: Cpha266_1916
CPB: Cphamn1_1745
PLT: Plut_1524
CTS: Ctha_0358
RRS: RoseRS_2867
RCA: Rcas_2430
CAU: Caur_0504 Caur_3337
CAG: Cagg_3177
CHL: Chy400_0540 Chy400_3599
HAU: Haur_2797
CMA: Cmaq_1623
Taxonomy
Structures PDB: 1A4L  1A4M  1ADD  1FKW  1FKX  1KRM  1NDV  1NDW  1NDY  1NDZ  
     1O5R  1QXL  1UIO  1UIP  1UML  1V79  1V7A  1VFL  1W1I  1WXY  
     1WXZ  2ADA  2AMX  2BGN  2E1W  2PGF  2PGR  2QVN  2Z7G  3B8F  
     3EWC  3EWD  3IAR  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:14927650]
KAPLAN NO, COLOWICK SP, CIOTTI MM.
Enzymatic deamination of adenosine derivatives.
J. Biol. Chem. 194 (1952) 579-91.
Aspergillus sp.
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:13303984]
POWELL JF, HUNTER JR.
Adenosine deaminase and ribosidase in spores of Bacillus cereus.
Biochem. J. 62 (1956) 381-7.
Bacillus cereus
Other DBs ExplorEnz - The Enzyme Database: 3.5.4.4
IUBMB Enzyme Nomenclature: 3.5.4.4
ExPASy - ENZYME nomenclature database: 3.5.4.4
BRENDA, the Enzyme Database: 3.5.4.4
CAS: 9026-93-1
DBGET integrated database retrieval system