| Entry |
|
|---|
| Name |
arylacetonitrilase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In nitriles
 |
|---|
| Sysname |
arylacetonitrile aminohydrolase |
|---|
| Reaction(IUBMB) |
4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH3
[RN:R04140] |
|---|
| Reaction(KEGG) |
R04140;
(other) R00540
 |
|---|
| Substrate |
4-chlorophenylacetonitrile [CPD:C03679];
H2O [CPD:C00001] |
|---|
| Product |
4-chlorophenylacetate [CPD:C03077];
NH3 [CPD:C00014] |
|---|
| Comment |
Requires thiol compounds. Also hydrolyses other 4-substituted
phenylacetonitriles, thien-2-ylacetonitrile, tolylacetonitriles,
and, more slowly, benzyl cyanide. |
|---|
| Pathway |
PATH: ec00460 Cyanoamino acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
|
1
Mauger, J., Nagasawa, T. and Yamada, H.
Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes
faecalis JM3.
Arch. Microbiol. 155 (1990) 1-6. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2269298]
Nagasawa T, Mauger J, Yamada H.
A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3.
Purification and characterization.
Eur. J. Biochem. 194 (1990) 765-72.
Alcaligenes faecalis |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.5.5
IUBMB Enzyme Nomenclature: 3.5.5.5
ExPASy - ENZYME nomenclature database: 3.5.5.5
BRENDA, the Enzyme Database: 3.5.5.5
CAS: 132053-06-6 |
|---|
