| Entry |
|
|---|
| Name |
glucosamine-6-phosphate deaminase;
glucosaminephosphate isomerase;
glucosamine-6-phosphate isomerase;
phosphoglucosaminisomerase;
glucosamine phosphate deaminase;
aminodeoxyglucosephosphate isomerase;
phosphoglucosamine isomerase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
 |
|---|
| Sysname |
2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol
isomerizing) |
|---|
| Reaction(IUBMB) |
D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
[RN:R00765] |
|---|
| Reaction(KEGG) |
R00765
 |
|---|
| Substrate |
D-glucosamine 6-phosphate [CPD:C00352];
H2O [CPD:C00001] |
|---|
| Product |
D-fructose 6-phosphate [CPD:C00085];
NH3 [CPD:C00014] |
|---|
| Effector |
N-Acetyl-D-glucosamine 6-phosphate [CPD:C00357] |
|---|
| Comment |
Isomerization of the aldose-ketose type converts the -CH(-NH2)-CH=O
group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming
2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield
fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine
6-phosphate, which is not broken down, activates the enzyme. |
|---|
| Pathway |
PATH: ec00520 Amino sugar and nucleotide sugar metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01504 glucosamine-6-phosphate isomerase
KO: K02564 glucosamine-6-phosphate deaminase |
|---|
| Genes |
HSA: 10007(GNPDA1) 132789(GNPDA2)
PTR: 738888(GNPDA1) 740946(GNPDA2)
MCC: 703036(GNPDA1)
MMU: 26384(Gnpda1) 67980(Gnpda2)
RNO: 289608(Gnpda2) 683570(Gnpda1)
CFA: 478043(GNPDA1) 608049(GNPDA2)
BTA: 508383(GNPDA2) 522919(GNPDA1)
ECB: 100061298 100062333
MDO: 100012448 100014957
OAA: 100078670
GGA: 416341(GNPDA1) 422772(GNPDA2)
TGU: 100229809
XLA: 398874(gnpda2) 398943
XTR: 100124908(gnpda2)
DRE: 550565(gnpda1) 556291
CIN: 100184260
SPU: 585301
DME: Dmel_CG6957(Oscillin)
DPO: Dpse_GA19983
DAN: Dana_GF15148
DER: Dere_GG25080
DPE: Dper_GL25853
DSE: Dsec_GM18555
DYA: Dyak_GE25482
DGR: Dgri_GH10296
DMO: Dmoj_GI17992
AGA: AgaP_AGAP009305
AAG: AaeL_AAEL013877
CQU: CpipJ_CPIJ008074
AME: 409520
NVI: 100115436
TCA: 663992
API: 100168570
ISC: IscW_ISCW018498
CEL: T03F6.3
CBR: CBG21221
SMM: Smp_091850
NVE: NEMVE_v1g180131
HMG: 100215470
TAD: TRIADDRAFT_33724
DHA: DEHA0F26070g
PIC: PICST_62706(NAG1)
LEL: LELG_03675
CTP: CTRG_03727
CDU: CD36_65540(NAG1)
YLI: YALI0C01419g
NCR: NCU04727
PAN: PODANSg2985
MGR: MGG_00625
FGR: FG07692.1 FG08398.1
AFM: AFUA_1G00480 AFUA_8G04070
AFV: AFLA_012080
PCS: Pc22g10040
CIM: CIMG_04411
URE: UREG_01640
SSL: SS1G_12835
BFU: BC1G_05323
CNE: CNM01050
CNB: CNBM0910
MPR: MPER_11146
MBR: MONBRDRAFT_34109
DDI: DDB_0234126(nagB2)
EHI: EHI_174640
EDI: EDI_063870
TET: TTHERM_00243730
PTM: GSPATT00025676001
TBR: Tb11.01.8520
TCR: 511025.50 511531.50
LMA: LmjF32.3260
LIF: LinJ32.3820
LBZ: LbrM32_V2.3550
GLA: GL50803_10829
ECO: b0678(nagB)
ECJ: JW0664(nagB)
ECD: ECDH10B_0743(nagB)
EBW: BWG_0538(nagB)
ECE: Z0825(nagB)
ECS: ECs0708(nagB)
ECF: ECH74115_0769(nagB)
ETW: ECSP_0725(nagB)
ECG: E2348C_0560(nagB)
ECC: c0753(nagB)
ECI: UTI89_C0672(nagB)
ECP: ECP_0690(nagB)
ECV: APECO1_1394(nagB)
ECW: EcE24377A_0703(nagB)
ECX: EcHS_A0722(nagB)
ECM: EcSMS35_0698(nagB)
ECY: ECSE_0738(nagB)
ECL: EcolC_2978(nagB)
ECK: EC55989_0664(nagB)
ECQ: ECED1_0659(nagB)
ECR: ECIAI1_0656(nagB)
ECT: ECIAI39_0635(nagB)
ECZ: ECS88_0703(nagB)
EUM: ECUMN_0763(nagB)
ELF: LF82_1440(nagB)
EBL: B21_00626(nagB)
EBD: ECBD_2984
EBR: ECB_00635(nagB)
EOH: ECO103_0674(nagB)
EOI: ECO111_0697(nagB)
EOJ: ECO26_0742(nagB)
EFE: EFER_2431(nagB)
STY: STY0722(nagB)
STT: t2191(nagB)
SPT: SPA2057(nagB)
SEK: SSPA1918(nagB)
SPQ: SPAB_02859(nagB)
SEI: SPC_0693(nagB)
SEC: SC0705(nagB)
SEH: SeHA_C0803(nagB)
SEE: SNSL254_A0743(nagB)
SEW: SeSA_A0839(nagB)
SEA: SeAg_B0731(nagB)
SED: SeD_A0790(nagB)
SEG: SG0681(nagB)
SET: SEN0648(nagB)
SES: SARI_02257(nagB)
STM: STM0684(nagB)
YPE: YPO2627(nagB)
YPK: y1202(nagB)
YPM: YP_1086(nagB)
YPA: YPA_2470(nagB)
YPN: YPN_1113(nagB)
YPG: YpAngola_A0338(nagB)
YPP: YPDSF_2626(nagB)
YPS: YPTB1119(nagB)
YPI: YpsIP31758_2909(nagB)
YPY: YPK_2997(nagB)
YPB: YPTS_1177(nagB)
YEN: YE2979(nagB)
SFL: SF0615(nagB)
SFX: S0626(nagB)
SFV: SFV_0653(nagB)
SSN: SSON_0632(nagB)
SBO: SBO_0540(nagB)
SBC: SbBS512_E0573(nagB)
SDY: SDY_0612(nagB)
ECA: ECA1326(nagB)
PCT: PC1_1203
PWA: Pecwa_3128
ETA: ETA_23310(nagB)
PLU: plu1317(nagB)
PAY: PAU_03089(nagB)
SGL: SG0858(nagB)
ENT: Ent638_1193(nagB)
ESA: ESA_02661(nagB)
CTU: Ctu_12920(nagB)
KPN: KPN_00699(nagB)
KPE: KPK_3874(nagB)
KPU: KP1_1650(nagB)
CKO: CKO_02486(nagB)
SPE: Spro_1227(nagB)
PMR: PMI0454(nagB)
EIC: NT01EI_2908
ETR: ETAE_2617(nagB)
BFL: Bfl323(nagB)
BPN: BPEN_331(nagB)
DDA: Dd703_1114
DDC: Dd586_1159
DZE: Dd1591_2942
HIN: HI0141(nagB)
HIT: NTHI0227(nagB)
HIP: CGSHiEE_02580(nagB)
HDU: HD1847(nagB)
HAP: HAPS_2072(nagB)
HSO: HS_1027(nagB)
HSM: HSM_1505(nagB)
PMU: PM0875(nagB)
MSU: MS2205(nagB)
APL: APL_1755(nagB)
APJ: APJL_1790(nagB)
APA: APP7_1840(nagB)
AAP: NT05HA_0549
AAT: D11S_1579
VCH: VCA1025(nagB)
VCO: VC0395_0216(nagB)
VCM: VCM66_A0983(nagB)
VCJ: VCD_000316
VVU: VV2_1200(nagB)
VVY: VVA0028(nagB)
VPA: VPA0038(nagB)
VHA: VIBHAR_07002(nagB)
VSP: VS_II1435(nagB)
VEX: VEA_000962
VFI: VF_2357(nagB)
VFM: VFMJ11_2478(nagB)
VSA: VSAL_I2812(nagB)
PPR: PBPRA1031(nagB) PBPRB0360(nagB)
PFO: Pfl01_1005
CJA: CJA_1164(nagB)
SLO: Shew_0815
SSE: Ssed_0844
SPL: Spea_0760 Spea_1521
SHL: Shal_0813
SWD: Swoo_0943
SWP: swp_4289
CPS: CPS_1008(nagB)
PHA: PSHAb0148(nagB)
PIN: Ping_0490(nagB)
HCH: HCH_06984(nagB)
MMW: Mmwyl1_1652
AHA: AHA_1526(nagB)
ASA: ASA_2828(nagB)
TAU: Tola_2136
REH: H16_A0315(nagB)
BMA: BMA3170
BMV: BMASAVP1_A0140
BML: BMA10229_A1448
BMN: BMA10247_2876
BPS: BPSL0497
BPM: BURPS1710b_0722
BPL: BURPS1106A_0553
BPD: BURPS668_0536
BTE: BTH_I0448
BXE: Bxe_A4154
VEI: Veis_1394(nagB)
DSA: Desal_2921
MXA: MXAN_6371(nagB)
SFU: Sfum_2912
MLO: mll4767
MES: Meso_1508 Meso_2864
SME: SMc02877
ATC: AGR_C_4724
BME: BMEII0384
BMF: BAB2_0323(nagB)
BMB: BruAb2_0321(nagB)
BMS: BRA0912(nagB)
CCR: CC_0444 CC_0535
SIL: SPO1843
RSQ: Rsph17025_4131
JAN: Jann_0886
RDE: RD1_1726
GOX: GOX1470
MAG: amb2734
BSU: BSU02360(nagBB) BSU35020(nagBA)
BHA: BH0420(nagB)
BAN: BA4273(nagB)
BAR: GBAA4273(nagB)
BAA: BA_4733
BAT: BAS3964(nagB)
BAH: BAMEG_4314(nagB)
BAI: BAA_4296(nagB)
BCE: BC4054(nagB)
BCA: BCE_4121(nagB)
BCZ: BCZK3810(nagB)
BCR: BCAH187_A4185(nagB)
BCB: BCB4264_A4163(nagB)
BCU: BCAH820_4074(nagB)
BCG: BCG9842_B1075(nagB)
BCQ: BCQ_3844(nagB)
BCX: BCA_4166(nagB)
BCY: Bcer98_2753(nagB)
BTK: BT9727_3795(nagB)
BTL: BALH_3670(nagB)
BWE: BcerKBAB4_3883(nagB)
BLI: BL00085(nagB) BL00599
BLD: BLi00726(nagB) BLi04349
BCL: ABC1490(nagB)
BAY: RBAM_032210(nagB)
BPU: BPUM_3139(nagB)
OIH: OB0611
GKA: GK2276
GTN: GTNG_2204
GWC: GWCH70_2216
GYM: GYMC10_0564 GYMC10_1212 GYMC10_1471
GYC: GYMC61_0405
SAU: SA0527(nagB)
SAV: SAV0569(nagB)
SAW: SAHV_0567(nagB)
SAM: MW0524(nagB)
SAR: SAR0573
SAS: SAS0527
SAC: SACOL0616(nagB)
SAB: SAB0519
SAA: SAUSA300_0554
SAX: USA300HOU_0563(nagB)
SAO: SAOUHSC_00552
SAJ: SaurJH9_0592
SAH: SaurJH1_0606
SAE: NWMN_0532
SAD: SAAV_0532(nagB)
SEP: SE0340
SER: SERP0215(nagB)
SHA: SH0278
SSP: SSP0235 SSP2149
SCA: Sca_0227(nagB) Sca_2393(nagB)
LMO: lmo0957 lmo2358
LMF: LMOf2365_0977(nagB) LMOf2365_2328
LMH: LMHCC_0247 LMHCC_1665(nagB)
LMC: Lm4b_00977 Lm4b_02322
LIN: lin0956 lin2452
LWE: lwe0939(nagB) lwe2301
LSP: Bsph_0351 Bsph_2350
ESI: Exig_0478(nagB)
EAT: EAT1b_2255
BBE: BBR47_45560(nagB)
PJD: Pjdr2_4465
LLA: L14408(nagB)
LLK: LLKF_1697(nagB)
LLC: LACR_1667
LLM: llmg_0928(nagB)
SPY: SPy_1399(nagB)
SPZ: M5005_Spy_1139(nagB)
SPM: spyM18_1407(nagB)
SPG: SpyM3_1065(nagB)
SPS: SPs0798
SPH: MGAS10270_Spy1209(nagB)
SPI: MGAS10750_Spy1246(nagB)
SPJ: MGAS2096_Spy1205(nagB)
SPK: MGAS9429_Spy1186(nagB)
SPF: SpyM50718(nagB)
SPA: M6_Spy1114
SPB: M28_Spy1133(nagB)
SOZ: Spy49_1115c(nagB)
SPN: SP_1415
SPD: SPD_1246(nagB)
SPR: spr1272(nagB)
SPW: SPCG_1403(nagB)
SPX: SPG_1356(nagB)
SNE: SPN23F_13800(nagB)
SPV: SPH_1546
SNM: SP70585_1454
SJJ: SPJ_1314
SPP: SPP_1434
SNT: SPT_0859
SAG: SAG0799(nagB)
SAN: gbs0819
SAK: SAK_0924(nagB)
SMU: SMU.636
STC: str0541(nagB)
STL: stu0541(nagB)
STE: STER_0581
SSA: SSA_0746(nagB)
SSU: SSU05_0634
SSV: SSU98_0634
SSB: SSUBM407_1233(nagB)
SSI: SSU0591(nagB)
SSS: SSUSC84_0564(nagB)
SGO: SGO_1586(nagB)
SEQ: SZO_13390
SEZ: Sez_0658(nagB)
SEU: SEQ_0683
SUB: SUB1239(nagB)
SDS: SDEG_1443(nagB)
LPL: lp_0226(gnp)
LPJ: JDM1_0209(gnp)
LJO: LJ1823
LJF: FI9785_1778(nagB)
LAC: LBA1948
LSA: LSA0417(nagB)
LSL: LSL_1465(nagB)
LDB: Ldb2190(nagB)
LBU: LBUL_2010
LBR: LVIS_0689
LCA: LSEI_2889
LCB: LCABL_31070(nagB)
LGA: LGAS_1861
LRE: Lreu_1026
LRF: LAR_0980
LHE: lhv_2077
LRH: LGG_02913(nagB)
LRL: LC705_02877(nagB)
PPE: PEPE_0335
EFA: EF0466(nagB)
OOE: OEOE_0644
LME: LEUM_0354
LCI: LCK_00258(nagB)
CAC: CAC0187(nagB)
CPE: CPE2434(nagB)
CPF: CPF_2744(nagB)
CPR: CPR_2431(nagB)
CTC: CTC02631(nagB)
CNO: NT01CX_1482(nagB)
CDF: CD1011(glmD)
CDC: CD196_0887(glmD)
CDL: CDR20291_0867(glmD)
CBO: CBO2833(nagB)
CBA: CLB_2777(nagB)
CBH: CLC_2710(nagB)
CBY: CLM_3197(nagB)
CBL: CLK_2221(nagB)
CBK: CLL_A0717(nagB)
CBB: CLD_1741(nagB)
CBI: CLJ_B3060(nagB)
CBT: CLH_0681(nagB)
CBF: CLI_2883(nagB)
CBE: Cbei_4562
CPY: Cphy_1521(nagB) Cphy_3582
AMT: Amet_4182
AOE: Clos_2224
STH: STH606
DSY: DSY3827
DHD: Dhaf_1549
APR: Apre_1656
EEL: EUBELI_20081
TTE: TTE1023(nagB)
TEX: Teth514_1433(nagB)
TPD: Teth39_0992(nagB)
NTH: Nther_2772
HOR: Hore_22920
MPU: MYPU_3620(nagB)
MPE: MYPE1760(nagB)
MMY: MSC_0129(nagB) MSC_0821(nagB)
MHY: mhp591(nagB)
MHJ: MHJ_0576(nagB)
MHP: MHP7448_0575(nagB)
MSY: MS53_0193(nagB)
MCP: MCAP_0128(nagB) MCAP_0749(nagB1)
ACL: ACL_0284
MSM: MSMEG_0501 MSMEG_2118(nagB)
CGL: NCgl2555(cgl2644)
CGB: cg2928(nagB)
CGT: cgR_2549
CEF: CE2518
CDI: DIP0521
CUR: cur_1512(nagB)
CAR: cauri_0238(nagB)
CKP: ckrop_1869(nagB)
RHA: RHA1_ro01547
RER: RER_09520(nagB) RER_12190(nagB) RER_39570(nagB)
ROP: ROP_12490(nagB)
SCO: SCO5236(nagB)
SMA: SAV_3018(nagB)
SGR: SGR_2277(nagB)
LXX: Lxx19480(nagB)
CMI: CMM_0354(nagB)
CMS: CMS_0923
ART: Arth_0180 Arth_2590(nagB) Arth_3512
AAU: AAur_2579(nagB)
ACH: Achl_2322 Achl_3405
RSA: RSal33209_1463(nagB)
BCV: Bcav_0591 Bcav_2749 Bcav_3353
BFA: Bfae_13500
JDE: Jden_0237
XCE: Xcel_1049
PAC: PPA0476(nagB)
NCA: Noca_4483
NML: Namu_0960
CAI: Caci_1961
BLO: BL1343(nagB)
BLJ: BLD_0209(nagB)
BLN: Blon_0881(nagB)
RXY: Rxyl_1731
CCU: Ccur_06760
SHI: Shel_00160
APV: Apar_0167
ELE: Elen_2155
BBU: BB0152(nagB)
BBZ: BbuZS7_0150(nagB)
BGA: BG0150(nagB)
BAF: BAPKO_0153(nagB)
BTU: BT0152(nagB)
BHR: BH0152(nagB)
BDU: BDU_153(nagB)
BRE: BRE_152(nagB)
TDE: TDE0337(nagB)
BHY: BHWA1_02378(nagB)
ABA: Acid345_2909(nagB)
SUS: Acid_3915(nagB)
BTH: BT_0258 BT_3587(nagB) BT_4127(nagB)
BFR: BF0984(nagB) BF3116
BFS: BF0905(nagB) BF2953
BVU: BVU_4120(nagB) BVU_4121
PGI: PG0803(nagB) PG1285
PGN: PGN_0606 PGN_0827(nagB)
PDI: BDI_0238 BDI_3568(nagB)
APS: CFPG_615
SRU: SRU_2530
RMR: Rmar_1219 Rmar_2077 Rmar_2791
CHU: CHU_1660(nagB)
DFE: Dfer_3264 Dfer_3813 Dfer_4486
CPI: Cpin_6570
PHE: Phep_0774 Phep_1699 Phep_3109 Phep_4142
FJO: Fjoh_2381 Fjoh_4557
COC: Coch_2021
RBI: RB2501_01555
FNU: FN1143(nagB)
LBA: Lebu_2136
STR: Sterm_2135 Sterm_3702
SMF: Smon_1208
OTE: Oter_1006
AMU: Amuc_1822
GAU: GAU_2002
RBA: RB1355(nagB) RB2532(nagB) RB3340 RB3556(gpi2)
EMI: Emin_1348
TAI: Taci_0236
SYW: SYNW0540(nagB)
SYC: syc0446_d
SYF: Synpcc7942_1103
SYD: Syncc9605_2143
SYE: Syncc9902_0534
SYG: sync_2246
SYR: SynRCC307_1837(nagB)
SYX: SynWH7803_1974(nagB)
CYT: cce_1331(nagB)
CYP: PCC8801_2098(nagB)
CYC: PCC7424_5244(nagB)
CYH: Cyan8802_2142
ANA: all0727(nagB)
NPU: Npun_R1302(nagB)
AVA: Ava_4629(nagB)
PMT: PMT1424
PMF: P9303_05361
TER: Tery_2627(nagB)
TTH: TTC1074
TTJ: TTHA1439
TTR: Tter_2131 Tter_2696
 |
|---|
| Structures |
PDB: 1J5X 1JT9 1NE7 2BKV 2BKX 2RI0 2RI1 2WU1 3HN6 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13549465]
COMB DG, ROSEMAN S.
Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase.
J. Biol. Chem. 232 (1958) 807-27.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14484386]
PATTABIRAMAN TN, BACHHAWAT BK.
Purification of glucosamine 6-phosphate deaminase from human brain.
Biochim. Biophys. Acta. 54 (1961) 273-83.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13403679]
WOLFE JB, BRITTON BB, NAKADA HI.
Glucosamine degradation by Escherichia coli. III. Isolation and
studies of phosphoglucosaminisomerase.
Arch. Biochem. Biophys. 66 (1957) 333-9.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.99.6
IUBMB Enzyme Nomenclature: 3.5.99.6
ExPASy - ENZYME nomenclature database: 3.5.99.6
BRENDA, the Enzyme Database: 3.5.99.6
CAS: 9013-10-9 |
|---|
